MINCLE and TLR9 agonists synergize to induce Th1/Th17 vaccine memory and mucosal recall in mice and non-human primates

Autor: Joshua S. Woodworth, Vanessa Contreras, Dennis Christensen, Thibaut Naninck, Nidhal Kahlaoui, Anne-Sophie Gallouët, Sébastien Langlois, Emma Burban, Candie Joly, Wesley Gros, Nathalie Dereuddre-Bosquet, Julie Morin, Ming Liu Olsen, Ida Rosenkrands, Ann-Kathrin Stein, Grith Krøyer Wood, Frank Follmann, Thomas Lindenstrøm, Tu Hu, Roger Le Grand, Gabriel Kristian Pedersen, Rasmus Mortensen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Development of new vaccines tailored for difficult-to-target diseases is hampered by a lack of diverse adjuvants for human use, and none of the currently available adjuvants induce Th17 cells. Here, we develop a liposomal adjuvant, CAF®10b,

Externí odkaz: https://doaj.org/article/247707a325064a6ea6e1237d4d196721

An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals

Autor: Anna Offersgaard, Carlos Rene Duarte Hernandez, Shan Feng, Pavel Marichal-Gallardo, Kenn Holmbeck, Anne Finne Pihl, Carlota Fernandez-Antunez, Garazi Peña Alzua, Katrine Top Hartmann, Long V. Pham, Yuyong Zhou, Karen Anbro Gammeltoft, Ulrik Fahnøe, Uffe Vest Schneider, Gabriel Kristian Pedersen, Henrik Elvang Jensen, Jan Pravsgaard Christensen, Santseharay Ramirez, Jens Bukh, Judith Margarete Gottwein

Publikováno v: iScience, Vol 26, Iss 2, Pp 105949- (2023)

Summary: Vaccines have relieved the public health burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and globally inactivated vaccines are most widely used. However, poor vaccination accessibility and waning immunity maintain the

Externí odkaz: https://doaj.org/article/5be313e70944483e85a0601f5bf5dfe3

Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice

Autor: Katharina Wørzner, Daniel J. Sheward, Signe Tandrup Schmidt, Leo Hanke, Julie Zimmermann, Gerald McInerney, Gunilla B. Karlsson Hedestam, Ben Murrell, Dennis Christensen, Gabriel Kristian Pedersen

Publikováno v: EBioMedicine, Vol 63, Iss , Pp 103197- (2021)

Background: SARS-CoV-2 has caused a global pandemic, infecting millions of people. A safe, effective vaccine is urgently needed and remains a global health priority. Subunit vaccines are used successfully against other viruses when administered in th

Externí odkaz: https://doaj.org/article/7ccd452217c5400cb56a66d0bbc2b3c7

A novel adjuvant formulation induces robust Th1/Th17 memory and mucosal recall responses in Non-Human Primates

Autor: Joshua S Woodworth, Vanessa Contreras, Dennis Christensen, Thibaut Naninck, Nidhal Kahlaoui, Anne-Sophie Gallouët, Sébastien Langlois, Emma Burban, Candie Joly, Wesley Gros, Nathalie Dereuddre-Bosquet, Julie Morin, Ming Liu Olsen, Ida Rosenkrands, Ann-Kathrin Stein, Grith Krøyer Wood, Frank Follmann, Thomas Lindenstrøm, Roger LeGrand, Gabriel Kristian Pedersen, Rasmus Mortensen

Publikováno v: bioRxiv

After clean drinking water, vaccination is the most impactful global health intervention. However, development of new vaccines against difficult-to-target diseases is hampered by the lack of diverse adjuvants for human use. Of particular interest, no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291e5396049394687d561c2c329b07d3
https://doi.org/10.1101/2023.02.23.529651

Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy

Autor: Dennis Christensen, Charlotta Polacek, Daniel J. Sheward, Leo Hanke, Ainhoa Moliner-Morro, Gerald McInerney, Ben Murrell, Katrine Top Hartmann, Henrik Elvang Jensen, Gregers Jungersen, Kristin Illigen, Louise Krag Isling, Rune Fledelius Jensen, Julia Sid Hansen, Ida Rosenkrands, Carlota Fernandez-Antunez, Santseharay Ramirez, Frank Follmann, Jens Bukh, Gabriel Kristian Pedersen

Publikováno v: Christensen, D, Polacek, C, Sheward, D J, Hanke, L, Moliner-morro, A, Mcinerney, G, Murrell, B, Hartmann, K T, Jensen, H E, Jungersen, G, Illigen, K, Isling, L K, Jensen, R F, Hansen, J S, Rosenkrands, I, Fernandez-antunez, C, Ramirez, S, Follmann, F, Bukh, J & Pedersen, G K 2022, ' Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy ', EBioMedicine, vol. 84, 104248 . https://doi.org/10.1016/j.ebiom.2022.104248

BackgroundLicensed vaccines against SARS-CoV-2 effectively protect against severe disease, but display incomplete protection against virus transmission. Mucosal vaccines providing immune responses in the upper airways are one strategy to protect agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2478ec4aa0e62dda8ed072c9896cfd5e
https://curis.ku.dk/portal/da/publications/protection-against-sarscov2-transmission-by-a-parenteral-primeintranasal-boost-vaccine-strategy(a89bca21-8a1d-4c31-b509-47e01826cdbd).html