Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gabriel Hoffman"'
Autor:
Gabor Egervari, Diana Akpoyibo, Tanni Rahman, John F. Fullard, James E. Callens, Joseph A. Landry, Annie Ly, Xianxiao Zhou, Noël Warren, Mads E. Hauberg, Gabriel Hoffman, Randy Ellis, Jacqueline-Marie N. Ferland, Michael L. Miller, Eva Keller, Bin Zhang, Panos Roussos, Yasmin L. Hurd
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Epigenetic mechanisms have emerged as contributors to the molecular impairments caused by exposure to environmental factors such as abused substances. Here the authors perform epigenetic profiling of the striatum and identify the tyrosine kinase FYN
Externí odkaz:
https://doaj.org/article/1d88bd91ce5342d1ae6c9fd044545db3
Autor:
Maria Paola Santini, Daniela Malide, Gabriel Hoffman, Gaurav Pandey, Valentina D’Escamard, Aya Nomura-Kitabayashi, Ilsa Rovira, Hiroshi Kataoka, Jordi Ochando, Richard P. Harvey, Toren Finkel, Jason C. Kovacic
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 555-570.e7 (2020)
Summary: PDGFRα+ mesenchymal progenitor cells are associated with pathological fibro-adipogenic processes. Conversely, a beneficial role for these cells during homeostasis or in response to revascularization and regeneration stimuli is suggested, bu
Externí odkaz:
https://doaj.org/article/5d6dc819cfc945e7a1b0544c09b2a120
Autor:
Benjamin Readhead, Brigham J. Hartley, Brian J. Eastwood, David A. Collier, David Evans, Richard Farias, Ching He, Gabriel Hoffman, Pamela Sklar, Joel T. Dudley, Eric E. Schadt, Radoslav Savić, Kristen J. Brennand
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Unbiased large scale screening of small molecules for drug discovery in psychiatric disease is technically challenging and financially costly. Here, Readhead and colleagues integrate in silico and in vitro approaches to design and conduct transcripto
Externí odkaz:
https://doaj.org/article/ed2d9e5658de4fa6b0313e02ddefca0f
Autor:
Attila Gulyás-Kovács, Ifat Keydar, Eva Xia, Menachem Fromer, Gabriel Hoffman, Douglas Ruderfer, Ravi Sachidanandam, Andrew Chess
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
This study analyzes allelic expression bias in post-mortem brains of healthy individuals and those diagnosed with schizophrenia or bipolar disorder. The study shows that the number of imprinted genes is consistent with low estimates, and that allelic
Externí odkaz:
https://doaj.org/article/087111815f63494a81b2581e8e19389c
Autor:
Benjamin Readhead, Brigham J. Hartley, Brian J. Eastwood, David A. Collier, David Evans, Richard Farias, Ching He, Gabriel Hoffman, Pamela Sklar, Joel T. Dudley, Eric E. Schadt, Radoslav Savić, Kristen J. Brennand
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the originally published version of this Article, the affiliation details for Eric E. Schadt and Radoslav Savic incorrectly omitted ‘Sema4, a Mount Sinai venture, Stamford, Connecticut, USA’. This has been corrected in both the PDF and HTML ve
Externí odkaz:
https://doaj.org/article/3227bb526fa5470faaa78282bcab2933
Autor:
Joseph P Jarvis, Laura B Scheinfeldt, Sameer Soi, Charla Lambert, Larsson Omberg, Bart Ferwerda, Alain Froment, Jean-Marie Bodo, William Beggs, Gabriel Hoffman, Jason Mezey, Sarah A Tishkoff
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002641 (2012)
African Pygmy groups show a distinctive pattern of phenotypic variation, including short stature, which is thought to reflect past adaptation to a tropical environment. Here, we analyze Illumina 1M SNP array data in three Western Pygmy populations fr
Externí odkaz:
https://doaj.org/article/d044d90fb4fe4c1cbac5c8237ae7f6fc
Autor:
David Burstein, Gabriel Hoffman, Deepika Mathur, Sanan Venkatesh, Karen Therrien, Ayman H. Fanous, Tim B. Bigdeli, Philip D. Harvey, Panos Roussos, Georgios Voloudakis
Publikováno v:
medRxiv
With the advent of healthcare-based genotyped biobanks, genome-wide association studies (GWAS) leverage larger sample sizes, incorporate patients with diverse ancestries and introduce noisier phenotypic definitions. Yet the extent and impact of pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad0514f729170ae97f79292e7649dc5
https://doi.org/10.1101/2023.01.17.23284670
https://doi.org/10.1101/2023.01.17.23284670
Autor:
Gabriel Hoffman
Publikováno v:
Biological Psychiatry. 93:S55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17adf0aae7f5186a1409e66a19070149
https://doi.org/10.1016/j.biopsych.2023.02.152
https://doi.org/10.1016/j.biopsych.2023.02.152
Autor:
David Burstein, Trevor Griffen, Karen Therrien, Jaroslav Bendl, Sanan Venkatesh, Pengfei Dong, Amirhossein Modabbernia, Biao Zeng, Deepika Mathur, Gabriel Hoffman, Robyn Sysko, Tom Hildebrandt, Georgios Voloudakis, Panos Roussos
Binge-eating disorder (BED) is the most common eating disorder yet its genetic architecture remains largely unknown. Studying BED is challenging because it is often comorbid with obesity, a common and highly polygenic trait, and it is underdiagnosed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d2e326d6399daff7821a9792b3f934
https://doi.org/10.1101/2022.04.28.22274437
https://doi.org/10.1101/2022.04.28.22274437
Autor:
Manuel Mattheisen, Jakob Grove, Thomas D. Als, Joanna Martin, Georgios Voloudakis, Sandra Meier, Ditte Demontis, Jaroslav Bendl, Raymond Walters, Caitlin E. Carey, Anders Rosengren, Nora I. Strom, Mads Engel Hauberg, Biao Zeng, Gabriel Hoffman, Wen Zhang, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Esben Agerbo, Bru Cormand, Merete Nordentoft, Thomas Werge, Ole Mors, David M. Hougaard, Joseph D. Buxbaum, Stephen V. Faraone, Barbara Franke, Søren Dalsgaard, Preben B. Mortensen, Elise B. Robinson, Panos Roussos, Benjamin M. Neale, Mark J. Daly, Anders D. Børglum
Publikováno v:
Nat Genet
Nature Genetics, 54, 1470-1478
Mattheisen, M, Grove, J, Als, T D, Martin, J, Voloudakis, G, Meier, S, Demontis, D, Bendl, J, Walters, R, Carey, C E, Rosengren, A, Strom, N I, Hauberg, M E, Zeng, B, Hoffman, G, Zhang, W, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Agerbo, E, Cormand, B, Nordentoft, M, Werge, T, Mors, O, Hougaard, D M, Buxbaum, J D, Faraone, S V, Franke, B, Dalsgaard, S, Mortensen, P B, Robinson, E B, Roussos, P, Neale, B M, Daly, M J & Børglum, A D 2022, ' Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups ', Nature Genetics, vol. 54, no. 10, pp. 1470-1478 . https://doi.org/10.1038/s41588-022-01171-3
Nature Genetics, 54, 10, pp. 1470-1478
Nature Genetics, 54, 1470-1478
Mattheisen, M, Grove, J, Als, T D, Martin, J, Voloudakis, G, Meier, S, Demontis, D, Bendl, J, Walters, R, Carey, C E, Rosengren, A, Strom, N I, Hauberg, M E, Zeng, B, Hoffman, G, Zhang, W, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Agerbo, E, Cormand, B, Nordentoft, M, Werge, T, Mors, O, Hougaard, D M, Buxbaum, J D, Faraone, S V, Franke, B, Dalsgaard, S, Mortensen, P B, Robinson, E B, Roussos, P, Neale, B M, Daly, M J & Børglum, A D 2022, ' Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups ', Nature Genetics, vol. 54, no. 10, pp. 1470-1478 . https://doi.org/10.1038/s41588-022-01171-3
Nature Genetics, 54, 10, pp. 1470-1478
Contains fulltext : 287469.pdf (Publisher’s version ) (Open Access) Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental conditions, with considerable overlap in their genetic et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e72ebb46bb6be0bb875d7cee6c9908