Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Gabriel Grenot"'
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Akademický článek
Oncogenic context shapes the fitness landscape of tumor suppression
Autor: Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the interactions between oncogenes and tumor suppressor genes that shape this landscape remain po
Externí odkaz: https://doaj.org/article/d8b8fe0a0e6941c7a811944dff8fc5cc
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3
Abstract 2789: Tumor suppressor genotype dramatically impacts lung cancer response to KRAS G12C inhibitors in vivo
Autor: Paul J. McMurdie, Ian P. Winters, Lily M. Blair, Lafia Sebastian, Vy Tran, Gabriel Grenot, Edwin A. Apilado, Ian K. Lai, Gregory D. Wall, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Joseph Juan
Publikováno v: Cancer Research. 83:2789-2789
Cancer is characterized by diverse genomic alterations that change cell state and can modify therapy responses. In some cases, the relationships between genotype and drug responses are obvious, such as the response of tumors with defined oncogenic mu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa40adf2377579e78ebee94007dfb388
https://doi.org/10.1158/1538-7445.am2023-2789
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5
Abstract 5723: An in vivo pharmacogenomics platform replicates and extends biomarkers of therapy response identified via causal inference analysis of clinical data
Autor: David Amar, Erick Scott, Ian P. Winters, Gregory D. Wall, Dmitri A. Petrov, Monte M. Winslow, Joseph Juan, Ian K. Lai, Lafia Sebastian, Edwin A. Apilado, Gabriel Grenot, Vy B. Tran, Charles Rudin, Michael J. Rosen
Publikováno v: Cancer Research. 83:5723-5723
Recent development of therapies targeting oncogenes have dramatically improved cancer care for subsets of patients and generated a wave of interest in cancer precision medicine. However, effective targeted therapies are scarce as we have a limited un
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::522bb2d49867a121490eb71cecb3ecf0
https://doi.org/10.1158/1538-7445.am2023-5723
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6
Abstract 2196: Oncogenic context drives the landscape of tumor suppression in lung cancer
Autor: Ian Winters, Lily Blair, Lafia Sebastian, Gabriel Grenot, Edwin Apilado, Wensheng Nie, Vy Tran, Ian Lai, Gregory Wall, Dmitri Petrov, Monte Winslow, Joseph Juan, Michael Rosen
Publikováno v: Cancer Research. 82:2196-2196
Cooperative interactions between genomic alterations in oncogenes and tumor suppressors are a hallmark of cancer. While molecular characterization of tens of thousands of primary tumors has solidified estimates of how frequently specific genomic alte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a485bb92ed2cf4895fa3a134e70f655c
https://doi.org/10.1158/1538-7445.am2022-2196
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