Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Gabriel G. Llanos"'
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Akademický článek
Withanolide-Type Steroids from Withania aristata as Potential Anti-Leukemic Agents
Autor: Laila M. Moujir, Gabriel G. Llanos, Liliana Araujo, Angel Amesty, Isabel L. Bazzocchi, Ignacio A. Jiménez
Publikováno v: Molecules, Vol 25, Iss 23, p 5744 (2020)
Leukemia is a blood or bone marrow cancer with increasing incidence in developed regions of the world. Currently, there is an ongoing need for novel and safe anti-leukemic agents, as no fully effective chemotherapy is available to treat this life-thr
Externí odkaz: https://doaj.org/article/f935ac33a9e44894bb1b5f35103bb960
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2
Expanding the Chemical Space of Withaferin A by Incorporating Silicon To Improve Its Clinical Potential on Human Ovarian Carcinoma Cells
Autor: Carolina P. Reyes, Farideh A. Javid, Isabel L. Bazzocchi, Ignacio A. Jiménez, Nayra R. Perestelo, Gabriel G. Llanos, Kartheek Sooda, Ángel Amesty, S. Afshinjavid
Publikováno v: Journal of Medicinal Chemistry. 62:4571-4585
Ovarian cancer represents the seventh most commonly diagnosed cancer worldwide. Herein, we report on the development of a withaferin A (WA)-silyl ether library with 30 analogues reported for the first time. Cytotoxicity assays on human epithelial ova
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7966454cc2270ea49cff6c01dd911962
https://doi.org/10.1021/acs.jmedchem.9b00146
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3
Withanolide-Type Steroids from Withania aristata as Potential Anti-Leukemic Agents
Autor: Gabriel G. Llanos, Isabel L. Bazzocchi, Ignacio A. Jiménez, Laila Moujir, Liliana Araujo, Ángel Amesty
Publikováno v: Molecules
Molecules, Vol 25, Iss 5744, p 5744 (2020)
Volume 25
Issue 23
Leukemia is a blood or bone marrow cancer with increasing incidence in developed regions of the world. Currently, there is an ongoing need for novel and safe anti-leukemic agents, as no fully effective chemotherapy is available to treat this life-thr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfe774a575afbbefb99dccef082d71c
http://europepmc.org/articles/PMC7731379
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4
Structure-based design, synthesis, and biological evaluation of withaferin A-analogues as potent apoptotic inducers
Autor: Isabel L. Bazzocchi, Gabriel G. Llanos, Laila Moujir, Ignacio A. Jiménez, Carlos Jiménez, Liliana Araujo, Jaime Rodríguez
Publikováno v: European Journal of Medicinal Chemistry. 140:52-64
Apoptosis inducers represent an attractive approach for the discovery and development of anticancer agents. Herein, we report on the development by molecular fine tuning of a withaferin A-based library of 63 compounds (2-64), 53 of them reported for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64553af8e6c7fff46ffcf0d74d8069d2
https://doi.org/10.1016/j.ejmech.2017.09.004
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5
Terpenoids from Maytenus Species and Assessment of Their Reversal Activity against a Multidrug-Resistant Leishmania tropica Line
Autor: Ignacio A. Jiménez, Gabriel G. Llanos, Isabel L. Bazzocchi, Francisco Gamarro, María L. Kennedy, Santiago Castanys
Publikováno v: Chemistry & Biodiversity. 8:2291-2298
The phytochemical analysis of the root bark extracts of the Chilean Maytenus, M. chubutensis, and M. magellanica (Celastraceae), led to the isolation of one phenolic nortriterpene, 1, and one diterpene with a nor-ent-kaurene skeleton, 2. In addition,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2db5fb01a5e1b47d5376482ae07a47b
https://doi.org/10.1002/cbdv.201000356
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8
Metabolites from Withania aristata with potential phytotoxic activity
Autor: Gabriel G, Llanos, Rosa M, Varela, Ignacio A, Jiménez, José M G, Molinillo, Francisco A, Macías, Isabel L, Bazzocchi
Publikováno v: Natural product communications. 5(7)
A series of apocarotenoids (1-8) and one carotenoid (9) were isolated from the leaves of Withania aristata. In addition, the tetraacetylated apocarotenoid glucosides 10-12 were obtained by acetylation, with derivative 9-hydroxymegastigma-4,6E-dien-3-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70da0d27422e369acded213303b07a18
https://pubmed.ncbi.nlm.nih.gov/20734937
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