Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gabriel G. Gamber"'
Autor:
Florian Nigsch, Peter Aspesi, John A. Tallarico, Greg Wendel, Douglas S. Auld, Jeffery A. Porter, Horst Hemmerle, Bushell Simon, Luis Llamas, Gabriel G. Gamber, Labbe-Giguere Nancy, Daniel K. Baeschlin, Maude Patoor, Yuan Wang, Mathias Frederiksen, Felipa A. Mapa, Philip R. Skaanderup, Stephen M. Canham, Jeremy L. Jenkins, Karin Briner, Zhan Deng, Ayako Honda, Rishi K. Jain, Ansgar Schuffenhauer, Allen Cornett, Deborah Rothman, Daniel S. Palacios
Chemogenetic libraries, collections of well-defined chemical probes, provide tremendous value to biomedical research but require substantial effort to ensure diversity as well as quality of the contents. We have assembled a chemogenetic library by da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9142dd606a518f34fda2139182ee13b5
Autor:
Istvan J. Enyedy, Wanlin Yan, Vinayak Hosagrahara, Timothy A. McKinsey, Erik Meredith, Nicolas Soldermann, Keith A. Koch, Nikos Pagratis, Qingming Zhu, Robin Burgis, Olga Rozhitskaya, Michael Paul Capparelli, Richard B. Vega, Ji-Hu Zhang, Chang Rao, Lauren G. Monovich, Kimberley Beattie, Gabriel G. Gamber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1447-1451
The synthesis and preliminary studies of the SAR of novel 3,5-diarylazole inhibitors of Protein Kinase D (PKD) are reported. Notably, optimized compounds in this class have been found to be active in cellular assays of phosphorylation-dependant HDAC5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415a80ddabae37926dced21c7706873a
https://doi.org/10.1016/j.bmcl.2011.01.014
https://doi.org/10.1016/j.bmcl.2011.01.014
Autor:
Chang Rao, Vinayak Hosagrahara, Robin Burgis, Richard B. Vega, Erik Meredith, Craig F. Plato, Nicolas Soldermann, Gabriel G. Gamber, Clayton Springer, David B. Hood, Joseph Chapo, Michael Paul Capparelli, Lauren G. Monovich, Istvan J. Enyedy, Qingming Zhu, Keith A. Koch, Dillon Phan, Dipietro Lucian, Olga Rozhitskaya, Timothy A. McKinsey, Kimberly Beattie, Maurice Van Eis, Nikos Pagratis, Karl Miranda, Wendy Lee, Wanlin Yan, Douglas D. Lemon, Charles F. Jewell
Publikováno v:
Journal of Medicinal Chemistry. 53:5422-5438
The synthesis and biological evaluation of potent and selective PKD inhibitors are described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC kinases. The PKD inhibitors of the present study blunt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c82fa2f1be9c93760777c118a2af64
https://doi.org/10.1021/jm100076w
https://doi.org/10.1021/jm100076w
Autor:
Travis J. Williams, Theodore C. Jessop, Joshua C. Horan, Gabriel G. Gamber, Paul A. Wender, Cindy Kan, Kanaka Pattabiraman, Stacey E. Brenner, Michael O. Clarke, Jeremy L. Baryza
Publikováno v:
Pure and Applied Chemistry. 75:143-155
Studies in our laboratory focus on problems in chemistry (new reactions and syn- thesis), biology (novel modes of action), and medicine (new therapeutic leads and drug deliv- ery systems). These interconnected and often synergistic activities are ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f59cd3a6c51e21424ac22615aa2d5ba
https://doi.org/10.1351/pac200375020143
https://doi.org/10.1351/pac200375020143
Autor:
Travis J. Williams, Paul A. Wender, Robert D. Hubbard, Robert Sun, Francis Gosselin, F. Christopher Bi, Lei Zhang, Gabriel G. Gamber, Marc J. C. Scanio
Publikováno v:
Pure and Applied Chemistry. 74:25-31
Studies in our laboratory are directed at the advancement of synthesis, biology, and medicine. This lecture will focus on new transition metal-catalyzed reactions that have been inspired by biologically potent targets such as phorbol and Taxol® and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62cabac60cf324dea8751b8eb2e333c8
https://doi.org/10.1351/pac200274010025
https://doi.org/10.1351/pac200274010025
Autor:
Qingming Zhu, Bushell Simon, Stacey Tiamfook, JoAnne Dzink-Fox, Michael A. Patane, Jason T. Brewer, Deborah Palestrant, Elin M. Rann, Matthew J. LaMarche, Meena Sachdeva, Anna Trzasko, Lewis Whitehead, Jennifer A. Leeds, Steve Mullin, Janetta Dewhurst, Lac Lee, Wanlin Yan, David McKenney, Gabriel G. Gamber, Jian Ding, Aregahegn Yifru, Adam Amaral, Jian Shao, Donghui Yu, Gejing Deng, Kwangho Lee, Troy Lister, Colin P. Osborne, Akash Jain
Publikováno v:
Journal of medicinal chemistry. 55(5)
Clostridium difficile (C. difficile) is a Gram positive, anaerobic bacterium that infects the lumen of the large intestine and produces toxins. This results in a range of syndromes from mild diarrhea to severe toxic megacolon and death. Alarmingly, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384c1bda3979597c478a8efdea5840cb
https://pubmed.ncbi.nlm.nih.gov/22315981
https://pubmed.ncbi.nlm.nih.gov/22315981
Publikováno v:
Angewandte Chemie. 113:4013-4015
Four new bonds and up to four new stereocenters are formed in the title reactions which allow the conversion of readily available starting materials into complex bicyclo[5.4.0]undecane derivatives. The reactions are performed in a single, simple oper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815151253a87cc74edb3d13a400c615f
https://doi.org/10.1002/1521-3757(20011015)113:20<4013::aid-ange4013>3.0.co
https://doi.org/10.1002/1521-3757(20011015)113:20<4013::aid-ange4013>3.0.co
Publikováno v:
ChemInform. 33
Four new bonds and up to four new stereocenters are formed in the title reactions which allow the conversion of readily available starting materials into complex bicyclo[5.4.0]undecane derivatives. The reactions are performed in a single, simple oper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99fc65c37a0a49a916049b631fa54fbb
https://doi.org/10.1002/chin.200206036
https://doi.org/10.1002/chin.200206036
Publikováno v:
ChemInform. 33
Prompted by our studies of transition metal-catalyzed [4+4], [4+2], [5+2], and [6+2] cycloadditions and by the view that these two-component reactions could be intercepted by a third component of one or more atoms, a new three-component transition me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e641fabc6cc341c4ae01b5741d7f6d9
https://doi.org/10.1002/chin.200231033
https://doi.org/10.1002/chin.200231033
Autor:
Robert D. Hubbard, Marc J. C. Scanio, Paul A. Wender, Travis J. Williams, Lei Zhang, F. Christopher Bi, Francis Gosselin, Robert Sun, Gabriel G. Gamber
Publikováno v:
ChemInform. 33
Studies in our laboratory are directed at the advancement of synthesis, biology, and medicine. This lecture will focus on new transition metal-catalyzed reactions that have been inspired by biologically potent targets such as phorbol and Taxol ® and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa271ba718a555fdd5faf90ee370dc9e
https://doi.org/10.1002/chin.200241295
https://doi.org/10.1002/chin.200241295