Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gabriel E. Santiago"'
Autor:
Pierre-Jacques Hamard, Gabriel E. Santiago, Fan Liu, Daniel L. Karl, Concepcion Martinez, Na Man, Adnan K. Mookhtiar, Stephanie Duffort, Sarah Greenblatt, Ramiro E. Verdun, Stephen D. Nimer
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2643-2657 (2018)
Summary: Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer types and is a promising therapeutic target for several of them, including leukemia and lymphoma. However, we and others have reported that PRMT5 is essential for n
Externí odkaz:
https://doaj.org/article/3f53d8256d1a4982a660f6bf4d6b6001
Autor:
Stephen P. Methot, Ludivine C. Litzler, Poorani Ganesh Subramani, Anil K. Eranki, Heather Fifield, Anne-Marie Patenaude, Julian C. Gilmore, Gabriel E. Santiago, Halil Bagci, Jean-François Côté, Mani Larijani, Ramiro E. Verdun, Javier M. Di Noia
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Activation-induced deaminase (AID) is important for inducing desirable mutations at the B cell receptor genes for effective antibody responses. Here the authors show that three key arginine residues of AID link AID-chromatin association with transcri
Externí odkaz:
https://doaj.org/article/4b68ae1b781848de928edd5a95b1ea1e
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic gamma-herpesvirus that causes AIDS-associated Kaposi sarcoma (KS) and several lymphoproliferative disorders. During the humoral immune response antigen-activated mature B cells acquire
Externí odkaz:
https://doaj.org/article/d411553938c74b6b9df962b0e1cf9669
Autor:
Stephanie Duffort, Stephen D. Nimer, Ramiro E. Verdun, Adnan K. Mookhtiar, Fan Liu, Concepción Martínez, Sarah Greenblatt, Gabriel E. Santiago, Pierre-Jacques Hamard, Na Man, Daniel L. Karl
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2643-2657 (2018)
Summary: Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer types and is a promising therapeutic target for several of them, including leukemia and lymphoma. However, we and others have reported that PRMT5 is essential for n
Autor:
Elena M. Cortizas, Andrew J. Gentles, Xiaoqing Lu, Francisco Vega, Izidore S. Lossos, Daniel Bilbao-Cortes, Gabriel E. Santiago, Shlomzion Aumann, Salma Parvin, Ramiro E. Verdun, Yu Zhang, Eden Sharabi, Jennifer R. Chapman, Natalia Weich, Ariel Ramirez-Labrada, Isidro Sánchez-García, Evan R. Roberts
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Deficiency in DNA double-strand break (DSB) repair mechanisms has been widely exploited for the treatment of different malignances, including homologous recombination (HR)-deficient breast and ovarian cancers. Here we demonstrate that diffuse large B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fd63a1dbab7f8d7ac087add2aa91f7
http://hdl.handle.net/10261/203471
http://hdl.handle.net/10261/203471
Publikováno v:
The Journal of Immunology. 197:2930-2935
The ∼28-kb 3′ regulatory region (3′RR), which is located at the most distal 3′ region of the Ig H chain locus, has multiple regulatory functions that control IgH expression, class-switch recombination (CSR), and somatic hypermutation. In this
Autor:
Ludivine C. Litzler, Poorani Ganesh Subramani, Mani Larijani, Heather Fifield, Stephen P. Methot, Anne-Marie Patenaude, Jean-François Côté, Halil Bagci, Julian C. Gilmore, Javier M. Di Noia, Anil K. Eranki, Gabriel E. Santiago, Ramiro E. Verdun
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
Activation-induced deaminase (AID) mutates the immunoglobulin (Ig) genes to initiate somatic hypermutation (SHM) and class switch recombination (CSR) in B cells, thus underpinning antibody responses. AID mutates a few hundred other loci, but most AID
Autor:
Izidore S. Lossos, Ariel Ramirez Labrada, Aumann Shlomzion, Francisco Vega, Ramiro E. Verdun, Salma Parvin, Jennifer R. Chapman-Fredricks, Isidro Sánchez-García, Sharabi Eden, Zhang Yu, Gabriel E. Santiago, Cortizas M Elena
Publikováno v:
Blood. 132:674-674
Novel therapies for DLBCL are needed to improve patients' outcomes. LIM domain only 2 (LMO2) protein is ubiquitously expressed and plays important roles in endothelial and hematopoietic cell development. LMO2 protein expression is upregulated in germ
Autor:
Ramiro E. Verdun, Izidore S. Lossos, Ariel Ramirez Labrada, Salma Parvin, Elena M. Cortizas, Elena Cubedo Gil, Gabriel E. Santiago
Publikováno v:
Blood. 128:776-776
Diffuse large B-cell lymphoma (DLBCL) is the most common and aggressive type of Non-Hodgkin Lymphoma (NHL). However, about 40% of patients still do not respond to the current therapy and die. Therefore, there is an urgent need for developing new stra