Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gabriel D. Román-Meléndez"'
Autor:
Gabriel D. Román-Meléndez, Daniel R. Monaco, Janelle M. Montagne, Rachel S. Quizon, Maximilian F. Konig, Mekbib Astatke, Erika Darrah, H. Benjamin Larman
Publikováno v:
EBioMedicine, Vol 71, Iss , Pp 103506- (2021)
Background: Post-translational modifications (PTMs) on proteins can be targeted by antibodies associated with autoimmunity. Despite a growing appreciation for their intrinsic role in disease, there is a lack of highly multiplexed serological assays t
Externí odkaz:
https://doaj.org/article/82af569aa0244ab8905c2ce7c8ac7508
Autor:
H. Benjamin Larman, Maximilian F. Konig, Daniel R. Monaco, Mekbib Astatke, Gabriel D. Román-Meléndez, Rachel S. Quizon, Erika Darrah, Janelle M. Montagne
Post-translational modifications (PTMs) on proteins can be targeted by antibodies associated with autoimmunity. Despite a growing appreciation for their intrinsic role in disease, there is a lack of highly multiplexed serological assays to characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b79f4c2a0c80eb9b5ffaeb923c40b991
https://doi.org/10.1101/2021.04.22.441021
https://doi.org/10.1101/2021.04.22.441021
Endopeptidases catalyze the internal cleavage of proteins, playing pivotal roles in protein turnover, substrate maturation and the activation of signaling cascades. A broad range of biological functions in health and disease are controlled by proteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f27255748b63405cea0b023c1be52c2
Publikováno v:
Cell systems. 11(4)
Summary Endopeptidases catalyze the internal cleavage of proteins, playing pivotal roles in protein turnover, substrate maturation, and the activation of signaling cascades. A broad range of biological functions in health and disease are controlled b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f141f32f42d19455dea3b13c684be3b7
https://pubmed.ncbi.nlm.nih.gov/33099407
https://pubmed.ncbi.nlm.nih.gov/33099407
Autor:
Brian R. Alzua, Jiarui Wang, Rory P. Woldring, Alan M. McClain, Gabriel D. Román-Meléndez, E. Neil G. Marsh
Publikováno v:
ACS Chemical Biology
The radical S-adenosylmethionine (SAM) superfamily of enzymes catalyzes an amazingly diverse variety of reactions ranging from simple hydrogen abstraction to complicated multistep rearrangements and insertions. The reactions they catalyze are importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582e13f0321b7d999623de02f497090d
https://doi.org/10.1021/cb5004674
https://doi.org/10.1021/cb5004674
Autor:
Caitlyn Makins, Paige A. Malec, Gabriel D. Román-Meléndez, Robert T. Kennedy, Soumi Ghosh, E. Neil G. Marsh
Publikováno v:
The Journal of biological chemistry. 291(52)
Viperin is an endoplasmic reticulum-associated antiviral responsive protein that is highly up-regulated in eukaryotic cells upon viral infection through both interferon-dependent and independent pathways. Viperin is predicted to be a radical S-adenos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1267a6dbcb5737e37678d6e705b947e
https://pubmed.ncbi.nlm.nih.gov/27834682
https://pubmed.ncbi.nlm.nih.gov/27834682
Autor:
E. Neil G. Marsh, Jeremy N. Harvey, Gabriel D. Román-Meléndez, Patrick von Glehn, Adrian J. Mulholland
Publikováno v:
Biochemistry. 53(1)
Adenosylcobalamin (AdoCbl) serves as a source of reactive free radicals that are generated by homolytic scission of the coenzyme's cobalt-carbon bond. AdoCbl-dependent enzymes accelerate AdoCbl homolysis by ∼10(12)-fold, but the mechanism by which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a87d588f4a88a0a0db9e56b01996a3
https://pubmed.ncbi.nlm.nih.gov/24341954
https://pubmed.ncbi.nlm.nih.gov/24341954
Publikováno v:
Biochimica et biophysica acta. 1824(11)
Adenosylcobalamin (coenzyme B(12)) serves as the cofactor for a group of enzymes that catalyze unusual rearrangement or elimination reactions. The role of the cofactor as the initiator of reactive free radicals needed for these reactions is well esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c72774dc67c94c887a1e21cd47719a2
https://pubmed.ncbi.nlm.nih.gov/22516318
https://pubmed.ncbi.nlm.nih.gov/22516318