Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Gabriel Cornilescu"'
Autor:
Fa-An Chao, Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor, Nitya Ramakrishnan, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu, Gabriel Cornilescu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high interest for elucidating the mechanisms by which RAS proteins interact with effectors and regulators and for designing inhibitors. Among several o
Externí odkaz:
https://doaj.org/article/69321b8535d54b5689b2d175700764dc
Autor:
Juliet O. Obi, Mulu Y. Lubula, Gabriel Cornilescu, Amy Henrickson, Kara McGuire, Chiara M. Evans, Margaret Phillips, Samuel P. Boyson, Borries Demeler, John L. Markley, Karen C. Glass
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 104-115 (2020)
Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHD finger protein 1 (BRPF1)
Externí odkaz:
https://doaj.org/article/373be060f02e4b3cb3c3da481b1aace9
Autor:
Chiara M. Evans, Margaret Phillips, Kiera L. Malone, Marco Tonelli, Gabriel Cornilescu, Claudia Cornilescu, Simon J. Holton, Mátyás Gorjánácz, Liping Wang, Samuel Carlson, Jamie C. Gay, Jay C. Nix, Borries Demeler, John L. Markley, Karen C. Glass
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9128 (2021)
The ATPase Family, AAA domain-containing protein 2 (ATAD2) bromodomain (BRD) has a canonical bromodomain structure consisting of four α-helices. ATAD2 functions as a co-activator of the androgen and estrogen receptors as well as the MYC and E2F tran
Externí odkaz:
https://doaj.org/article/c130bf1e716a48bfbb4258fbbdf20d6b
Autor:
Om Kumar Shrestha, Ruchika Sharma, Bartlomiej Tomiczek, Woonghee Lee, Marco Tonelli, Gabriel Cornilescu, Milena Stolarska, Lukasz Nierzwicki, Jacek Czub, John L Markley, Jaroslaw Marszalek, Szymon J Ciesielski, Elizabeth A Craig
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217098 (2019)
The J-domain protein Zuotin is a multi-domain eukaryotic Hsp70 co-chaperone. Though it is primarily ribosome-associated, positioned at the exit of the 60S subunit tunnel where it promotes folding of nascent polypeptide chains, Zuotin also has off-rib
Externí odkaz:
https://doaj.org/article/b09f12cb237047c2956e4aed7205ec36
Autor:
Brenda A Schilke, Szymon J Ciesielski, Thomas Ziegelhoffer, Erina Kamiya, Marco Tonelli, Woonghee Lee, Gabriel Cornilescu, Justin K Hines, John L Markley, Elizabeth A Craig
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007084 (2017)
By binding to a multitude of polypeptide substrates, Hsp70-based molecular chaperone systems perform a range of cellular functions. All J-protein co-chaperones play the essential role, via action of their J-domains, of stimulating the ATPase activity
Externí odkaz:
https://doaj.org/article/3b39ed135dee43bd8878ef4ccb38a39f
Autor:
Fa-An Chao, Srisathiyanarayanan Dharmaiah, Troy Taylor, Simon Messing, William Gillette, Dominic Esposito, Dwight V. Nissley, Frank McCormick, R. Andrew Byrd, Dhirendra K. Simanshu, Gabriel Cornilescu
Publikováno v:
Journal of the American Chemical Society. 144:4196-4205
KRAS is the most frequently mutated RAS protein in cancer patients, and it is estimated that about 20% of the cancer patients in the United States carried mutant RAS proteins. To accelerate therapeutic development, structures and dynamics of RAS prot
Autor:
Kyle P. Smith, Woonghee Lee, Marco Tonelli, Yeongjoon Lee, Samuel H. Light, Gabriel Cornilescu, Srinivas Chakravarthy
Publikováno v:
Protein Sci
The bacterial pathogen Vibrio cholerae use a type III secretion system to inject effector proteins into a host cell. Recently, a putative Toxic GTPase Activating Protein (ToxGAP) called Vibrio outer protein E (VopE) was identified as a T3SS substrate
Autor:
Jonathan T. Lloyd, Kyle McLaughlin, Mulu Y. Lubula, Jamie C. Gay, Andrea Dest, Cong Gao, Margaret Phillips, Marco Tonelli, Gabriel Cornilescu, Matthew R. Marunde, Chiara M. Evans, Samuel P. Boyson, Samuel Carlson, Michael-Christopher Keogh, John L. Markley, Seth Frietze, Karen C. Glass
Publikováno v:
J Med Chem
Bromodomains are chromatin reader modules that recognize acetylated lysine. Different bromodomains exhibit a preference for specific patterns of lysine acetylation marks on core and variant histone proteins, however, the functional relationships that
Publikováno v:
Proc Natl Acad Sci U S A
Streptococcus pneumoniae is an opportunistic human pathogen that utilizes the competence regulon, a quorum-sensing circuitry, to acquire antibiotic resistance genes and initiate its attack on the human host. Interception of the competence regulon can
Autor:
Mulu Y. Lubula, Margaret Phillips, Gabriel Cornilescu, Juliet O. Obi, Karen C. Glass, Samuel P. Boyson, John L. Markley, Amy Henrickson, Chiara M. Evans, Kara McGuire, Borries Demeler
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss, Pp 104-115 (2020)
Curr Res Struct Biol
Curr Res Struct Biol
Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHD finger protein 1 (BRPF1)