Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Gabriel C Léger"'
Autor:
Howard H Feldman, José A Luchsinger, Gabriel C Léger, Curtis Taylor, Diane M Jacobs, David P Salmon, Steven D Edland, Karen Messer, Carolyn Revta, Sarah A Flowers, Kerry S Jones, Albert Koulman, Kevin E Yarasheski, Philip B Verghese, Venky Venkatesh, Henrik Zetterberg, January Durant, Jody-Lynn Lupo, Gary E Gibson, ADCS BenfoTeam Study Group
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302998 (2024)
BackgroundBenfotiamine provides an important novel therapeutic direction in Alzheimer's disease (AD) with possible additive or synergistic effects to amyloid targeting therapeutic approaches.ObjectiveTo conduct a seamless phase 2A-2B proof of concept
Externí odkaz:
https://doaj.org/article/1adfda9ed09d49c99461ba5018b477fc
Autor:
Gabriel C Léger, Nancy Johnson
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol 2007, Iss Issue 6, Pp 745-752 (2007)
Gabriel C Léger1,2, Nancy Johnson31Neurology Service, Hôtel-Dieu du Centre Hospitalier de l’Univertité de Montréal, Montréal, Québec, Canada; 2Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada; 3Cognitive Neurology and
Externí odkaz:
https://doaj.org/article/89dfcdc02562488aa0d52c3412c9006e
Autor:
Neal R. Swerdlow, Yash B. Joshi, Joyce Sprock, Jo Talledo, Juan L. Molina, Lisa Delano-Wood, Dylan Iwanaga, Juliana E. Kotz, Steven Huege, Gabriel C. Léger, Gregory A. Light
Publikováno v:
Journal of Alzheimer's disease : JAD. 91(1)
Background: The uncompetitive NMDA antagonist, memantine (MEM), enhances prepulse inhibition of startle (PPI) across species. MEM is used to treat Alzheimer’s disease (AD); conceivably, its acute impact on PPI might be used to predict a patient’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb1166f4cc1a2eba8bd172f71db6443
https://pubmed.ncbi.nlm.nih.gov/36404550
https://pubmed.ncbi.nlm.nih.gov/36404550
Autor:
Alexander Ivan B. Posis, Wassim Tarraf, Kevin A. Gonzalez, Jose A. Soria-Lopez, Gabriel C. Léger, Ariana M. Stickel, Martha L. Daviglus, Melissa Lamar, Donglin Zeng, Hector M. González
Publikováno v:
J Alzheimers Dis
Journal of Alzheimer's disease : JAD, vol 86, iss 1
Journal of Alzheimer's disease : JAD, vol 86, iss 1
Background: Studies of cumulative anticholinergic drug burden on cognitive function and impairment are emerging, yet few for Hispanics/Latinos. Objective: To examine associations between anticholinergic use and neurocognitive performance outcomes amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418d16f90d90eb693c837261aa54df73
https://europepmc.org/articles/PMC9632492/
https://europepmc.org/articles/PMC9632492/
Autor:
Mark Guttman, Gabriel C. Léger
Publikováno v:
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT ISBN: 9780429278983
This chapter reviews the current information on the use of Positron emission tomography (PET) and movement disorders. Parkinson’s disease is a degenerative neurological disorder characterized by tremor, rigidity, bradykinesia, and postural instabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b8c0dff0736864a10b440f058c1338e
https://doi.org/10.4324/9780429278983-21
https://doi.org/10.4324/9780429278983-21
Autor:
Robert A. Rissman, Annie Hiniker, Douglas Galasko, Yu Zhao, Diane M. Jacobs, Guerry M. Peavy, Denis S. Smirnov, David P. Salmon, Vanessa Goodwill, Steven D. Edland, Gabriel C. Léger, Lawrence A. Hansen, Donald P. Pizzo
Publikováno v:
Neurology
Background and ObjectivePatients with earlier age at onset of sporadic Alzheimer disease (AD) are more likely than those with later onset to present with atypical clinical and cognitive features. We sought to determine whether this age-related clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f9d5db1f55fe1253c227fec2d17377
https://pubmed.ncbi.nlm.nih.gov/34810247
https://pubmed.ncbi.nlm.nih.gov/34810247
Autor:
Joanne Taylor, Neill R. Graff-Radford, Kelley Faber, Walter A. Kukull, Tania F. Gendron, Alexander Pantelyat, Daniel I. Kaufer, Emma Lagone, Rosa Rademakers, Bradley F. Boeve, Howard J. Rosen, Leonard Petrucelli, Arthur W. Toga, Marwan N. Sabbagh, Diana Wheaton, Joel H. Kramer, Jeremy Syrjanen, Walter K. Kremers, Diane Lucente, Peter A. Ljubenkov, Anne M. Fagan, Dennis W. Dickson, Zbigniew K. Wszolek, Aaron Ritter, Leah K. Forsberg, Danielle Brushaber, Belen Pascual, Domoto-Reilly Kimiko, Patrick Brannelly, Anna Karydas, Hugo Botha, Daniel H. Geschwind, Bonnie Wong, Erik D. Roberson, Nupur Ghoshal, Doug R. Galasko, David J. Irwin, Jonathan Graff-Radford, Ging-Yuek Robin Hsiung, Murray Grossman, Adam M. Staffaroni, Toji Miyagawa, Edward D. Huey, Chiadi U. Onyike, Eliana Marisa Ramos, Eric J. Huang, John Kornak, Gabriel C. Léger, Carmela Tartaglia, Jessica E. Rexach, Tatiana Foroud, Scott M. McGinnis, Adam L. Boxer, David T.W. Jones, Irene Litvan, Rodney Pearlman, William W. Seeley, Yvette Bordelon, Masood Manoochehri, Julio C. Rojas, Sandra Weintraub, Bruce L. Miller, David S. Knopman, Katherine P. Rankin, Kejal Kantarci, Ian Grant, Ralitza H. Gavrilova, Joseph C. Masdeu, Ann Fishman, David P. Salmon, Julie A. Fields, Kevin M. Nelson, Brad C. Dickerson, Brian S. Appleby, Joanna M. Biernacka, Katya Rascovsky, Jill Goldman, Mario F. Mendez, Hilary W. Heuer, Ian R. A. Mackenzie, Rodolfo Savica, Nadine Tatton
Publikováno v:
Alzheimer's & Dementia. 16
Author(s): Boeve, Bradley F; Boxer, Adam L; Rosen, Howard J; Forsberg, Leah K; Heuer, Hilary W; Brushaber, Danielle; Appleby, Brian; Biernacka, Joanna M; Bordelon, Yvette M; Botha, Hugo; Brannelly, Patrick; Dickerson, Brad C; Dickson, Dennis W; Kimik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50b8b7582284dbb980fa5db79953e00b
https://doi.org/10.1002/alz.045482
https://doi.org/10.1002/alz.045482
Publikováno v:
Handbook of clinical neurology. 167
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and functional decline associated with age together with a particular neuropathology. It was first described by Alois Alzheimer in 1906 about a patient whom he fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7becec80edf942c2864d7afc1333bef7
https://pubmed.ncbi.nlm.nih.gov/31753135
https://pubmed.ncbi.nlm.nih.gov/31753135
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 4, Iss 1, Pp 43-46 (2016)
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Introduction The Activities of Daily Living Questionnaire (ADL-Q) is an informant report questionnaire assessing functional impairment in daily living skills. Previous research has demonstrated correlations between ADL-Q and cognitive screening measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cd3592b5a06d957ba6d7b2cf60b04f