Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes

Autor: Varun Bhaskar, Alexandra Graff-Meyer, Andreas D. Schenk, Simone Cavadini, Ottilie von Loeffelholz, S. Kundhavai Natchiar, Caroline G. Artus-Revel, Hans-Rudolf Hotz, Gabriel Bretones, Bruno P. Klaholz, Jeffrey A. Chao

Publikováno v: Cell Reports, Vol 31, Iss 1, Pp - (2020)

Summary: Ribosomes undergo multiple conformational transitions during translation elongation. Here, we report the high-resolution cryoelectron microscopy (cryo-EM) structure of the human 80S ribosome in the post-decoding pre-translocation state (clas

Externí odkaz: https://doaj.org/article/ab271bc4b7cf423480279f3743614470

p21 as a transcriptional co-repressor of S-phase and mitotic control genes.

Autor: Nuria Ferrándiz, Juan M Caraballo, Lucía García-Gutierrez, Vikram Devgan, Manuel Rodriguez-Paredes, M Carmen Lafita, Gabriel Bretones, Andrea Quintanilla, M Jose Muñoz-Alonso, Rosa Blanco, Jose C Reyes, Neus Agell, M Dolores Delgado, G Paolo Dotto, Javier León

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37759 (2012)

It has been previously described that p21 functions not only as a CDK inhibitor but also as a transcriptional co-repressor in some systems. To investigate the roles of p21 in transcriptional control, we studied the gene expression changes in two huma

Externí odkaz: https://doaj.org/article/32600aef584b489fad30b84dc5ce7907

Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells

Autor: Alejandro P Ugalde, Gabriel Bretones, David Rodríguez, Víctor Quesada, Francisco Llorente, Raúl Fernández‐Delgado, Miguel Ángel Jiménez‐Clavero, Jesús Vázquez, Enrique Calvo, Isaac Tamargo‐Gómez, Guillermo Mariño, David Roiz‐Valle, Daniel Maeso, Miguel Araujo‐Voces, Yaiza Español, Carles Barceló, José MP Freije, Alejandro López‐Soto, Carlos López‐Otín

Publikováno v: Scopus
Digital.CSIC. Repositorio Institucional del CSIC
instname

Better understanding on interactions between SARS-CoV-2andhost cells should help to identify host factors that may be tar-getable to combat infection and COVID-19pathology. To this end,we have conducted a genome-wide CRISPR/Cas9-based loss-of-functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8549e09b854434b683e0002aab0959f9
http://hdl.handle.net/10651/66710

Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma

Autor: Juan Flores-Montero, Juan José Garcés, Xabier Agirre, Idoia Rodriguez, Rafael Del Orbe, Bruno Paiva, Paula Rodriguez-Otero, Felipe Prosper, Pethema, Maria-Victoria Mateos, Halima El Omri, Luzalba Sanoja-Flores, Rafael Valdés-Mas, Sara Rodriguez, Alberto Orfao, Joan Bladé, Miguel-García Álvarez, Jesús F. San Miguel, Noemi Puig, Laura Rosiñol, Luis Palomera, Carlos López-Otín, Albert Pérez-Montaña, Juan José Lahuerta, Maria-Teresa Cedena, Joaquin Martinez-Lopez, Rafael Rios, Leire Burgos, Gabriel Bretones, Maria-Jose Calasanz, Diego Alignani, Diana A. Puente, Pamela Millacoy, Ibai Goicoechea

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Leukemia

Multiple myeloma (MM) patients undergo repetitive bone marrow (BM) aspirates for genetic characterization. Circulating tumor cells (CTCs) are detectable in peripheral blood (PB) of virtually all MM cases and are prognostic, but their applicability fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436d2d1cf66409ba66adc37fef5a526c
http://hdl.handle.net/10261/230718

Giant tortoise genomes provide insights into longevity and age-related disease

Autor: Dido Carrero, Stephen J. Gaughran, Tomas Marques-Bonet, Isaac Tamargo-Gómez, Scott Glaberman, Miguel G. Álvarez, Kevin P. White, Ylenia Chiari, Zi-Feng Jiang, Adalgisa Caccone, Danielle L. Edwards, Olaya Santiago-Fernández, Joshua M. Miller, Víctor Quesada, María Pascual-Torner, José G. Pérez-Silva, David Roiz-Valle, James P. Gibbs, Gabriel Bretones, Javier R. Arango, Claudio Ciofi, Diana Campos-Iglesias, Carlos López-Otín, Sandra Freitas-Rodríguez, Washington Tapia, Luciano B. Beheregaray, Benjamin R. Evans, Nikos Poulakakis, Miguel Araujo-Voces, Michael A. Russello, Maud C. Quinzin, Pablo Mayoral, Lukas F. K. Kuderna, Danny Rueda, Ryan C. Garrick

Publikováno v: Nature ecology & evolution
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature ecology & evolution, vol 3, iss 1
Scopus
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
RUO. Repositorio Institucional de la Universidad de Oviedo
Nature Ecology & Evolution
Recercat. Dipósit de la Recerca de Catalunya
Quesada, V; Freitas-Rodríguez, S; Miller, J; Pérez-Silva, JG; Jiang, ZF; Tapia, W; et al.(2019). Giant tortoise genomes provide insights into longevity and age-related disease. Nature Ecology and Evolution, 3(1), 87-95. doi: 10.1038/s41559-018-0733-x. UC Merced: Retrieved from: http://www.escholarship.org/uc/item/8tb9j1g8

Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c056bae7b4b4abaaedc751f9cdff787
http://hdl.handle.net/10261/207258