Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes

Autor: Varun Bhaskar, Alexandra Graff-Meyer, Andreas D. Schenk, Simone Cavadini, Ottilie von Loeffelholz, S. Kundhavai Natchiar, Caroline G. Artus-Revel, Hans-Rudolf Hotz, Gabriel Bretones, Bruno P. Klaholz, Jeffrey A. Chao

Publikováno v: Cell Reports, Vol 31, Iss 1, Pp - (2020)

Summary: Ribosomes undergo multiple conformational transitions during translation elongation. Here, we report the high-resolution cryoelectron microscopy (cryo-EM) structure of the human 80S ribosome in the post-decoding pre-translocation state (clas

Externí odkaz: https://doaj.org/article/ab271bc4b7cf423480279f3743614470

Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation

Autor: Maria Pascual-Torner, Dido Carrero, José G. Pérez-Silva, Diana Álvarez-Puente, David Roiz-Valle, Gabriel Bretones, David Rodríguez, Daniel Maeso, Elena Mateo-González, Yaiza Español, Guillermo Mariño, José Luis Acuña, Víctor Quesada, Carlos López-Otín

Publikováno v: Scopus

Turritopsis dohrnii is the only metazoan able to rejuvenate repeatedly after its medusae reproduce, hinting at biological immortality and challenging our understanding of aging. We present and compare whole-genome assemblies of T. dohrnii and the non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08370545526c635f1e913bdcd6c41e86
https://doi.org/10.1073/pnas.2118763119

ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration

Autor: Álvaro F. Fernández, Etienne Morel, Sylvie Souquere, María F. Suárez, Antonio Fueyo, Guillermo Mariño, Isaac Tamargo-Gómez, Xurde M. Caravia, Patrice Codogno, Gemma G. Martínez-García, Carlos López-Otín, R. Cabo, Gérard Pierron, Helena Codina-Martínez, Veronica Rey, Gabriel Bretones, Cristina Tomás-Zapico, Nicolas Dupont

Publikováno v: Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
Universidad de las Islas Baleares
Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2021, ⟨10.1038/s41418-021-00776-1⟩
Autophagy

Despite the great advances in autophagy research in the last years, the specific functions of the four mammalian Atg4 proteases (ATG4A-D) remain unclear. In yeast, Atg4 mediates both Atg8 proteolytic activation, and its delipidation. However, it is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44787568903c963aaac273322c1d1909
http://hdl.handle.net/10651/61039

p21 as a transcriptional co-repressor of S-phase and mitotic control genes.

Autor: Nuria Ferrándiz, Juan M Caraballo, Lucía García-Gutierrez, Vikram Devgan, Manuel Rodriguez-Paredes, M Carmen Lafita, Gabriel Bretones, Andrea Quintanilla, M Jose Muñoz-Alonso, Rosa Blanco, Jose C Reyes, Neus Agell, M Dolores Delgado, G Paolo Dotto, Javier León

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37759 (2012)

It has been previously described that p21 functions not only as a CDK inhibitor but also as a transcriptional co-repressor in some systems. To investigate the roles of p21 in transcriptional control, we studied the gene expression changes in two huma

Externí odkaz: https://doaj.org/article/32600aef584b489fad30b84dc5ce7907

Giant tortoise genomes provide insights into longevity and age-related disease

Autor: Dido Carrero, Stephen J. Gaughran, Tomas Marques-Bonet, Isaac Tamargo-Gómez, Scott Glaberman, Miguel G. Álvarez, Kevin P. White, Ylenia Chiari, Zi-Feng Jiang, Adalgisa Caccone, Danielle L. Edwards, Olaya Santiago-Fernández, Joshua M. Miller, Víctor Quesada, María Pascual-Torner, José G. Pérez-Silva, David Roiz-Valle, James P. Gibbs, Gabriel Bretones, Javier R. Arango, Claudio Ciofi, Diana Campos-Iglesias, Carlos López-Otín, Sandra Freitas-Rodríguez, Washington Tapia, Luciano B. Beheregaray, Benjamin R. Evans, Nikos Poulakakis, Miguel Araujo-Voces, Michael A. Russello, Maud C. Quinzin, Pablo Mayoral, Lukas F. K. Kuderna, Danny Rueda, Ryan C. Garrick

Publikováno v: Nature ecology & evolution
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature ecology & evolution, vol 3, iss 1
Scopus
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
RUO. Repositorio Institucional de la Universidad de Oviedo
Nature Ecology & Evolution
Recercat. Dipósit de la Recerca de Catalunya
Quesada, V; Freitas-Rodríguez, S; Miller, J; Pérez-Silva, JG; Jiang, ZF; Tapia, W; et al.(2019). Giant tortoise genomes provide insights into longevity and age-related disease. Nature Ecology and Evolution, 3(1), 87-95. doi: 10.1038/s41559-018-0733-x. UC Merced: Retrieved from: http://www.escholarship.org/uc/item/8tb9j1g8

Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c056bae7b4b4abaaedc751f9cdff787
http://hdl.handle.net/10261/207258