Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gabriel A. Fitzgerald"'
Publikováno v:
eLife, Vol 6 (2017)
The number of ions required to drive substrate transport through a secondary active transporter determines the protein’s ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints o
Externí odkaz:
https://doaj.org/article/2c95ae11f56641b4938aab27982b7df7
Autor:
Daniel S. Terry, Scott C. Blanchard, Changhao He, Xiaoyu Wang, Gabriel A. Fitzgerald, Olga Boudker, Didar Ciftci, Gerard H. M. Huysmans, Zhou Zhou
Publikováno v:
Bio Protoc
Secondary active transporters reside in cell membranes transporting polar solutes like amino acids against steep concentration gradients, using electrochemical gradients of ions as energy sources. Commonly, ensemble-based measurements of radiolabeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc073b022f06579d71a318e3a479b64b
https://doi.org/10.21769/bioprotoc.3970
https://doi.org/10.21769/bioprotoc.3970
Autor:
Scott C. Blanchard, Olga Boudker, Changhao He, Gabriel A. Fitzgerald, Zhou Zhou, Didar Ciftci, Gerard H. M. Huysmans, Daniel S. Terry, Xiaoyu Wang
Publikováno v:
Science Advances
Single-molecule detection of transport turnovers shows a distribution of rates with fast transporters favored by mutations.
Kinetic properties of membrane transporters are typically poorly defined because high-resolution functional assays analog
Kinetic properties of membrane transporters are typically poorly defined because high-resolution functional assays analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beda62e3dfeb0ed2b4646768a709fb41
http://europepmc.org/articles/PMC7259943
http://europepmc.org/articles/PMC7259943
Autor:
Jake E. Batchelder, Scott C. Blanchard, Alessandro Borgia, Ouissam El Bakouri, Steffen Jockusch, Wesley B. Asher, Brandt C. Huddle, Gabriel A. Fitzgerald, Avik Kumar Pati, Michael D. Holsey, Jonathan A. Javitch, Henrik Ottosson, Chathura Abeywickrama, Dominic A. Rufa, Roger B. Altman, Zhou Zhou, Daniel S. Terry
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fluorescence imaging, a central pillar of medical and fundamental research, is hampered by stochastic blinking, limited photon budgets, and phototoxicities of organic fluorophores. Here, we use quantum chemical calculations and targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7597c08b84b206c22f71334225b33c
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423464
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423464
Publikováno v:
Biophysical Journal. 121:249a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7c796b9a205b972ebb67aecd77467a1
https://doi.org/10.1016/j.bpj.2021.11.1495
https://doi.org/10.1016/j.bpj.2021.11.1495
Autor:
Kirstie A. Thompson, John N. Marafino, Brandi L. Volkers, Brenna Walsh, Kevin L. Caran, Brenden K. Wimbish, David Bruno, Sybelle Djikeng, Gabriel A. Fitzgerald, Tara Gallagher, Kyle Seifert, Stephanie Masters, Nicholas T. Minahan, Jason L. Floyd, Kristin McKenna, Suma Haji, Monica Paneru
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 157:440-448
Hydra amphiphiles mimic the morphology of the mythical multi-headed creatures for which they are named. Likewise, when faced with a pathogenic bacterium, some hydra derivatives are as destructive as their fabled counterparts were to their adversaries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47044b9668cbdded8805127a89b6b901
https://doi.org/10.1016/j.colsurfb.2017.06.010
https://doi.org/10.1016/j.colsurfb.2017.06.010
Publikováno v:
Protein Expression and Purification
Sensitive and specific serology tests are essential for epidemiological and public health studies of COVID-19 and for vaccine efficacy testing. The presence of antibodies to SARS-CoV-2 surface glycoprotein (Spike) and, specifically, its receptor-bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96dde09575b900c001da767520f4d364
http://europepmc.org/articles/PMC7923943
http://europepmc.org/articles/PMC7923943
Autor:
Ouissam El Bakouri, Avik Kumar Pati, Jonathan A. Javitch, Gabriel A. Fitzgerald, Daniel S. Terry, Steffen Jockusch, Wesley B. Asher, Alessandro Borgia, Scott C. Blanchard, Zhou Zhou, Henrik Ottosson, Roger B. Altman
Publikováno v:
Biophysical Journal. 120:114a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e840310e48df1ae431ff772cfa82fc2a
https://doi.org/10.1016/j.bpj.2020.11.2271
https://doi.org/10.1016/j.bpj.2020.11.2271
Autor:
Jonathan A. Javitch, Matthias Quick, Gabriel A. Fitzgerald, Daniel S. Terry, Audrey L. Warren, Scott C. Blanchard
Publikováno v:
Nature
Secondary active transporters, which are vital for a multitude of physiological processes, use the energy of electrochemical ion gradients to power substrate transport across cell membranes1,2. Efforts to investigate their mechanisms of action have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d13f7b8ef90dc7fcdc5f2a853f8e2e1
https://doi.org/10.1038/s41586-020-2029-y
https://doi.org/10.1038/s41586-020-2029-y
Autor:
Kyle Seifert, Brenna Walsh, Tara Gallagher, Jhosdyn Barragan, Kristin McKenna, Kyle Bonifer, Nicholas T. Minahan, Kevin L. Caran, Jade E. LaDow, John N. Marafino, Jason L. Floyd, Brandi L. Volkers, Gabriel A. Fitzgerald
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:3566-3573
Two novel series of tris-cationic, tripled-headed, double-tailed amphiphiles were synthesized and the effects of tail length and head group composition on the critical aggregation concentration (CAC), thermodynamic parameters, and minimum inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a55f712db1b3bd3ed3da1855b54f4eb
https://doi.org/10.1016/j.bmc.2015.04.020
https://doi.org/10.1016/j.bmc.2015.04.020