Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Gabriel, Mbalaviele"'
Autor:
Gabriel Mbalaviele, Bernhard Ryffel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/3e7e975e175947e7924326c13c9dbc01
Publikováno v:
eLife, Vol 13 (2024)
Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including the skeleton,
Externí odkaz:
https://doaj.org/article/bfd734c8363b4b279837441bce66168d
IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Osteoarthritis is a joint disease characterized by a poorly-defined inflammatory response that does not encompass a massive immune cell infiltration yet contributes to cartilage degradation and loss of joint mobility, suggesting a chondrocyt
Externí odkaz:
https://doaj.org/article/21365e45f0c64be1ab2a0821cd13c1e2
Autor:
Tong Yang, Kai Sun, Chun Wang, Gaurav Swarnkar, Songtao Quan, Dustin Kress, Jianqiu Xiao, Yael Alippe, Hongjun Zheng, Robert H Brophy, Dingjun Hao, Audrey McAlinden, Yousef Abu-Amer, Jie Shen, Gabriel Mbalaviele
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Abstract Background Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also converts pro-interleukin-1β (pro-IL-1β) and pro-IL-18 into bioactive
Externí odkaz:
https://doaj.org/article/85e85314d3ee434fb76113941a98d1d4
Autor:
Manoj Arra, Gaurav Swarnkar, Naga Suresh Adapala, Syeda Kanwal Naqvi, Lei Cai, Muhammad Farooq Rai, Srikanth Singamaneni, Gabriel Mbalaviele, Robert Brophy, Yousef Abu-Amer
Publikováno v:
eLife, Vol 11 (2022)
Osteoarthritis is the most common joint disease in the world with significant societal consequences but lacks effective disease-modifying interventions. The pathophysiology consists of a prominent inflammatory component that can be targeted to preven
Externí odkaz:
https://doaj.org/article/f9c57b6e795848f5bbf6bb68c37c646d
Autor:
Kai Sun, Chun Wang, Jianqiu Xiao, Michael D Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J Silva, Jie Shen, Gabriel Mbalaviele
Publikováno v:
eLife, Vol 11 (2022)
Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18. Excessive GSDM-mediated pore formation can compromise the integrity of the plasma mem
Externí odkaz:
https://doaj.org/article/7ca9264616784893a0c9e2f16bce0ef6
Autor:
Manoj Arra, Gaurav Swarnkar, Ke Ke, Jesse E. Otero, Jun Ying, Xin Duan, Takashi Maruyama, Muhammad Farooq Rai, Regis J. O’Keefe, Gabriel Mbalaviele, Jie Shen, Yousef Abu-Amer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Chondrocytes have altered cellular metabolism in the context of osteoarthritis, but whether and how these changes are associated with inflammation is a controversial area. Here the authors show that inflammatory NF-κB signalling drives a glycolytic
Externí odkaz:
https://doaj.org/article/85329ba61e30432694e6760ca1cad04a
Publikováno v:
Journal of Translational Autoimmunity, Vol 5, Iss , Pp 100162- (2022)
Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GS
Externí odkaz:
https://doaj.org/article/21d698f5ae0a459f8d0b12bfbc60213d
Autor:
Alvaro González‐Dominguez, Raúl Montañez, Beatriz Castejón‐Vega, Jéssica Nuñez‐Vasco, Débora Lendines‐Cordero, Chun Wang, Gabriel Mbalaviele, José M Navarro‐Pando, Elísabet Alcocer‐Gómez, Mario D Cordero
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 10, Pp n/a-n/a (2021)
Abstract Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome pathway in HGPS
Externí odkaz:
https://doaj.org/article/741ada3b7d4b430aadbd36423e7df82b
Autor:
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L Kostecki, Joseph B Monahan, Deborah J Veis, Yousef Abu-Amer, Daniel C Link, Gabriel Mbalaviele
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000807 (2020)
Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation (BMT). Cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms remain poorly defined. Here, we use the syngeneic mouse BMT model to te
Externí odkaz:
https://doaj.org/article/dfcc01b5a9e84be9b30dca2343479fa0