Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gabor M. Harami"'
Autor:
Lili Hegedus, Agnes Toth, Gabor M. Harami, Janos Palinkas, Nargis Karatayeva, Eniko Sajben-Nagy, Szabolcs Bene, Sara Afzali Jaktajdinani, Mihaly Kovacs, Szilvia Juhasz, Peter Burkovics
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Genome replication is frequently impeded by highly stable DNA secondary structures, including G-quadruplex (G4) DNA, that can hinder the progression of the replication fork. Human WRNIP1 (Werner helicase Interacting Protein 1) associates wit
Externí odkaz:
https://doaj.org/article/ef8693911000466fb2cdcfe50eeb72f6
Autor:
Gábor M. Harami, János Pálinkás, Zoltán J. Kovács, Bálint Jezsó, Krisztián Tárnok, Hajnalka Harami-Papp, József Hegedüs, Lamiya Mahmudova, Nóra Kucsma, Szilárd Tóth, Gergely Szakács, Mihály Kovács
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110788- (2024)
Summary: Human single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) plays central roles in DNA repair. Here, we show that purified hSSB1 undergoes redox-dependent liquid-liquid phase separation (LLPS) in the presence of single-stranded DNA or R
Externí odkaz:
https://doaj.org/article/f900f8a1e9714c37a521aa897d38d7b2
Autor:
Gabor M. Harami, Keir C. Neuman
Publikováno v:
Journal of Molecular Biology. 434:167580
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6833d98321a2516be9234d4374ec279a
https://doi.org/10.1016/j.jmb.2022.167580
https://doi.org/10.1016/j.jmb.2022.167580
Autor:
Tamás Annus, Dalma Müller, Bálint Jezsó, György Ullaga, Barnabás Németh, Gábor M. Harami, László Orbán, Mihály Kovács, Máté Varga
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-11 (2022)
Abstract RecQ helicases—also known as the “guardians of the genome”—play crucial roles in genome integrity maintenance through their involvement in various DNA metabolic pathways. Aside from being conserved from bacteria to vertebrates, their
Externí odkaz:
https://doaj.org/article/11f72752893b4702b1c6bb45f136463e
Autor:
Gábor M. Harami, János Pálinkás, Yeonee Seol, Zoltán J. Kovács, Máté Gyimesi, Hajnalka Harami-Papp, Keir C. Neuman, Mihály Kovács
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Human Bloom’s syndrome (BLM) helicase has a role in DNA repair, and BLM deficiency in humans is associated with chromosomal abnormalities. Here the authors employ solution biophysical assays to show BLM maintains a balance for disruption and stabil
Externí odkaz:
https://doaj.org/article/9573787d49d34870aed73bd8e8268d4c
Publikováno v:
FEBS Open Bio, Vol 11, Iss 4, Pp 1054-1075 (2021)
DNA damage removal by nucleotide excision repair (NER) and replicative bypass via translesion synthesis (TLS) and template switch (TSw) are important in ensuring genome stability. In this study, we tested the applicability of an SV40 large T antigen
Externí odkaz:
https://doaj.org/article/62c18ee281124f56970f5aff1d364683