Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Gabor Kokeny"'
Autor:
Gantsetseg Garmaa, Stefania Bunduc, Tamás Kói, Péter Hegyi, Dezső Csupor, Dariimaa Ganbat, Fanni Dembrovszky, Fanni Adél Meznerics, Ailar Nasirzadeh, Cristina Barbagallo, Gábor Kökény
Publikováno v:
Non-Coding RNA, Vol 10, Iss 3, p 30 (2024)
Chronic kidney disease (CKD) represents an increasing health burden. Evidence suggests the importance of miRNA in diagnosing CKD, yet the reports are inconsistent. This study aimed to determine novel miRNA biomarkers and potential therapeutic targets
Externí odkaz:
https://doaj.org/article/a06669a7a0f546eb8f3aef66210544db
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15520 (2023)
Excessive renal TGF-β production and pro-fibrotic miRNAs are important drivers of kidney fibrosis that lack any efficient treatment. Dysfunctional autophagy might play an important role in the pathogenesis. We aimed to study the yet unknown effects
Externí odkaz:
https://doaj.org/article/7cbca5ab5ae048a9aab2eea476746449
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/38563663e67b40e5b5f10433e0ce9995
Autor:
Gábor Kökény, Tamás Bakos, Bálint András Barta, Georgina Viktória Nagy, Tamás Mészáros, Gergely T. Kozma, András Szabó, János Szebeni, Béla Merkely, Tamás Radovits
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1138 (2023)
Hemodynamic disturbance, a rise in neutrophil-to-lymphocyte ratio (NLR) and release of inflammatory cytokines into blood, is a bad prognostic indicator in severe COVID-19 and other diseases involving cytokine storm syndrome (CSS). The purpose of this
Externí odkaz:
https://doaj.org/article/7fc9338eab9f42f5b28dfb3d86327d70
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS C57Bl6/J (B6) mouse strain is resistant to several experimental models of renal fibrosis. Mesangial cells play an important role in the pathogenesis of glomerulosclerosis. Also, autophagy dysregulation was recently related to fibr
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10431, p 10431 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor, initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism. It promotes lipid uptake and adipogenesis by increasing insulin
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Overexpression of tissue inhibitors of metalloproteases (TIMPs) are a hallmark of renal fibrosis, and elevated TIMP-1 has been reported in experimental and human diabetes. Also, renal galectin-3 (Lgals3) overproduction might link
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Reduced peroxisome proliferator-activated receptor-γ (PPARγ) activity has been observed in chronic kidney disease and fibrosis. We have recently shown that the PPARγ agonist pioglitazone dampens TGF-β induced renal pro-fibroti
Autor:
Balázs Tamás Németh, Tamás Radovits, Attila Oláh, Béla Merkely, Alex Ali Sayour, Csaba Mátyás, Eszter M. Horváth, Kálmán Benke, Gabor Kokeny, Mihály Ruppert, István Hartyánszky, Zoltán Szabolcs, Gábor Szabó
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
While heart transplantation (HTX) is the definitive therapy of heart failure, donor shortage is emerging. Pharmacological activation of soluble guanylate cyclase (sGC) and increased cGMP-signalling have been reported to have cardioprotective properti
Autor:
Tamás Radovits, Gábor Szabó, Lilla Fang, Szabina Czirok, Béla Merkely, László Rosivall, Gabor Kokeny, Gábor Szénási
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Decreased soluble guanylate cyclase activity and cGMP levels in diabetic kidneys were shown to influence the progression of nephropathy. The regulatory effects of soluble guanylate cyclase activators on renal signaling pathways are still unknown, we