Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Gabor Butora"'
Autor:
Denise M Kenski, Gabor Butora, Aarron T Willingham, Abby J Cooper, Wenlang Fu, Ning Qi, Ferdie Soriano, Ian W Davies, W Michael Flanagan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Current modifications used in small interfering RNAs (siRNAs), such as 2’-methoxy (2’-OMe) and 2’-fluoro (2’-F), improve stability, specificity or immunogenic properties but do not improve potency. These modifications were previously designed
Externí odkaz:
https://doaj.org/article/e301ca9daab34f4f9bb7cf9bc702a584
Autor:
Edward C. Sherer, Zhen Li, Daniel Zewge, Gabor Butora, Ian W. Davies, Joseph D. Armstrong, Greg Copeland, David M. Tellers, Joseph R. Gouker, Daniel R. Sidler, Vasant Jadhav
Publikováno v:
Bioconjugate chemistry. 29(6)
An efficient multicomponent orthogonal protocol was developed for post-synthetic oligonucleotide modification using commercially available 2'- O-methyl ester and 2'- O-propargyl nucleoside scaffolds. Amidation of methyl esters with primary amines was
Publikováno v:
Angewandte Chemie. 126:14270-14274
The cytosolic conversion of therapeutically relevant nucleosides into bioactive triphosphates is often hampered by the inefficiency of the first kinase-mediated step. Nucleoside monophosphate prodrugs can be used to bypass this limitation. Herein we
Autor:
Lihu Yang, Gabor Butora, Malcolm MacCoss, Deodialsingh Guiadeen, Shankaran Kothandaraman, Sander G. Mills, George A. Doss
Publikováno v:
Tetrahedron Letters. 50:4050-4053
Methodology to rapidly and efficiently assemble 8-trifluoromethyltetrahydro-6H-pyrido [1,2-a] pyrazine-6-one (11) has been developed and its general applicability has been demonstrated.
Autor:
Richard Jiao, Pasquale P. Vicario, Gabor Butora, Shankaran Kothandaraman, Stephen D. Goble, Mary Struthers, Gregori J. Morriello, Julie A. DeMartino, Sander G. Mills, Malcolm MacCoss, Julia M. Ayala, Margaret A. Cascieri, Karla L. Donnely, Changyou Zhou, Lihu Yang, Alexander Pasternak
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1830-1834
A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found t
Autor:
Gabor Butora, Mark Stahlhut, Daniel R. McMasters, Malcolm MacCoss, David B. Olsen, Joseph F. Leone, Lihu Yang, Steven S. Carroll, George A. Doss, Xibin Liao
Publikováno v:
Tetrahedron Letters. 49:4149-4152
The synthesis of 2′-β- C -methyl-neplanocin derivatives is described. The key intermediate cyclopentenyl alcohol 12 is prepared from sugar 5 in 12 steps. Coupling of 12 with appropriately protected purine, 7-deaza pyrimidine, uracil and pyrimidine
Autor:
Christine Burlein, Steven S. Carroll, Gabor Butora, Malcolm MacCoss, Joseph F. Leone, Christoph Schmitt, Daniel R. McMasters, Mark Stahlhut, David B. Olsen
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5219-5229
As a part of an ongoing medicinal chemistry effort to identify inhibitors of the Hepatitis C Virus RNA replication, we report here the synthesis and biological evaluation of 9-deaza- and 7,9-dideaza-7-oxa-2′- C -methyladenosine. The parent 2′- C
Autor:
George A. Doss, Christoph Schmitt, Gabor Butora, Malcolm MacCoss, Eric Streckfuss, Dorothy Levorse
Publikováno v:
Tetrahedron. 63:3782-3789
The only successful synthesis of 8-fluoroadenosine reported until now relied on an enzymatic removal of the acetate protecting groups using thermally resistant hydrolases. In the present communication we describe the first non-enzymatic synthesis of
Autor:
Deodialsingh Guiadeen, William H. Parsons, Pasquale P. Vicario, Gregori J. Morriello, Malcolm MacCoss, Margaret A. Cascieri, Shankaran Kothandaraman, Alexander Pasternak, Lihu Yang, Gabor Butora
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4715-4722
A systematic examination of the central aromatic portion of the lead (2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluorophenyl)-4-(1′H-spiro[indene-1,4′-piperidin]-1′-yl)butanamide (9) led to the discovery of a novel class of CCR2 receptor anta
Autor:
Gabor Butora
Publikováno v:
Synthesis. 1998:665-681
A radical cyclization approach to the complete skeleton of morphine was investigated in several iterations. The first attempt at a radical cascade via a Bergman-type intermediate derived from ene-diyne 10 failed during a model study in which 10-membe