Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gabor Bunkoczi"'
Autor:
Mykhaylo Demydchuk, Chris H. Hill, Aiwu Zhou, Gábor Bunkóczi, Penelope E. Stein, Denis Marchesan, Janet E. Deane, Randy J. Read
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Hunter syndrome is a lysosomal storage disease caused by mutations in the enzyme iduronate-2-sulfatase (IDS). Here, the authors present the IDS crystal structure and give mechanistic insights into mutations that cause Hunter syndrome.
Externí odkaz:
https://doaj.org/article/73c38b90598b4907b8cedce5ff4f26cb
Autor:
Judith Reeks, Michael Saur, Harren Jhoti, Gabor Bunkoczi, Michael J. Hartshorn, Jing Dong, Pamela A. Williams
Publikováno v:
Drug Discovery Today. 25:485-490
Recent advances in electron cryo-microscopy (cryo-EM) structure determination have pushed the resolutions obtainable by the method into the range widely considered to be of utility for drug discovery. Here, we review the use of cryo-EM in fragment-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b2b90732ae4afc7a9a3b0bdc137819
https://doi.org/10.1016/j.drudis.2019.12.006
https://doi.org/10.1016/j.drudis.2019.12.006
Autor:
Stefan Knapp, Eidarus Salah, Panagis Filippakopoulos, Benjamin E. Turk, Gabor Bunkoczi, Wang Min, Frank Sobott, Haifeng Zhang, Sirlester A. Parker, Susanne Müller, Oleg Fedorov
Publikováno v:
Structure(London, England:1993)
Apoptosis signal-regulating kinase 1 (ASK1) plays an essential role in stress and immune response and has been linked to the development of several diseases. Here, we present the structure of the human ASK1 catalytic domain in complex with staurospor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b658e00fda82e9be883b84431465ba7
Publikováno v:
Journal of Biological Chemistry. 281:22004-22012
Modification of GTPases with isoprenoid molecules derived from geranylgeranyl pyrophosphate or farnesyl pyrophosphate is an essential requisite for cellular signaling pathways. The synthesis of these isoprenoids proceeds in mammals through the mevalo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f412c75c4b7a7f4ac9f0cf14f2868e0f
https://doi.org/10.1074/jbc.m602603200
https://doi.org/10.1074/jbc.m602603200
Publikováno v:
Structure(London, England:1993)
Summary About 10% of all protein kinases are predicted to be enzymatically inactive pseudokinases, but the structural details of kinase inactivation have remained unclear. We present the first structure of a pseudokinase, VRK3, and that of its closes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225e9f478937fdc6858f0e70f3bc80ad
http://ora.ox.ac.uk/objects/uuid:1780d073-bb26-4687-b799-ff5ab11aef8f
http://ora.ox.ac.uk/objects/uuid:1780d073-bb26-4687-b799-ff5ab11aef8f
Autor:
Stephanie Misquitta, Kathryn L. Kavanagh, Grazyna Kochan, Gabor Bunkoczi, Stuart Smith, Alexandra Rojkova, Xiaoqiu Wu, Wen Hwa Lee, Udo Oppermann
Publikováno v:
Chemistry and biology. (6)
SummaryAnimals employ two systems for the de novo biosynthesis of fatty acids: a megasynthase complex in the cytosol (type I) that produces mainly palmitate, and an ensemble of freestanding enzymes in the mitochondria (type II) that produces mainly o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ca86dda794a5230842752c26adfa9f
http://ora.ox.ac.uk/objects/uuid:343232d9-a7b7-43fd-8059-cd63fc05c8c9
http://ora.ox.ac.uk/objects/uuid:343232d9-a7b7-43fd-8059-cd63fc05c8c9
Autor:
Stephanie A. Misquitta, Viktoria Hozjan, Xiaoqiu Wu, Udo Oppermann, Stuart Smith, Gabor Bunkoczi, Kathryn L. Kavanagh
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05610d84e283fe9141cc8fd77d7f22fc
https://doi.org/10.1096/fasebj.22.1_supplement.1012.1
https://doi.org/10.1096/fasebj.22.1_supplement.1012.1
Autor:
Kathryn L. Kavanagh, Xiaoqiu Wu, Anil K. Joshi, Saloni Pasta, Stuart Smith, Udo Oppermann, Gabor Bunkoczi
Publikováno v:
Chemistry & Biology
Mammals utilize a single phosphopantetheinyl transferase for the posttranslational modification of at least three different apoproteins: the carrier protein components of cytosolic and mitochondrial fatty acid synthases and the aminoadipate semialdeh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60efc2da6638fa99efbfd6b1464ae5aa
https://pubmed.ncbi.nlm.nih.gov/18022563
https://pubmed.ncbi.nlm.nih.gov/18022563
Autor:
Petra, Lukacik, Brigitte, Keller, Gabor, Bunkoczi, Kathryn L, Kavanagh, Kathryn, Kavanagh, Wen Hwa, Lee, Wen, Hwa Lee, Jerzy, Adamski, Udo, Oppermann
To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously functionally uncharacterized product of the human DHRS10 gene is endowed with 17β-HSD (17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5b88f79b5b6453538f7527f59cafaa
https://europepmc.org/articles/PMC1876366/
https://europepmc.org/articles/PMC1876366/
Autor:
Dante Neculai, Ana-Mirela Neculai, Herbert W. Roesky, Gabor Bunkoczi, Christopher C. Cummins, Dietmar Stalke, Bernhardt Walfort
Publikováno v:
Inorganic chemistry. 42(26)
Sc(BrMgL)(2)Br (L = (R(2)NCH(2)CH(2)NCMe)(2)CH, R = H) was studied by DFT methods leading to the conclusion that this diamagnetic formal scandium(I) system enjoys stabilization of its Sc-based filled d(yz)() orbital by a delta-acceptor linear combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0e4aa6a0c89442442ab936103d5902
https://pubmed.ncbi.nlm.nih.gov/14686860
https://pubmed.ncbi.nlm.nih.gov/14686860