Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Gabor, Jarai"'
Autor:
Pitchumani Sivakumar, Ron Ammar, John Ryan Thompson, Yi Luo, Denis Streltsov, Mary Porteous, Carly McCoubrey, Edward Cantu, Michael F. Beers, Gabor Jarai, Jason D. Christie
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a significant unmet medical need. Development of transformational therapies for IPF is challenging in part to due to lack of robust predictive biomarkers of prognosi
Externí odkaz:
https://doaj.org/article/e669f581a774421099ad94ddbc23a0a9
SOMAscan Proteomics Identifies Serum Biomarkers Associated With Liver Fibrosis in Patients With NASH
Autor:
Yi Luo, Samir Wadhawan, Alex Greenfield, Benjamin E. Decato, Abdul M. Oseini, Rebecca Collen, Diane E. Shevell, John Thompson, Gabor Jarai, Edgar D. Charles, Arun J. Sanyal
Publikováno v:
Hepatology Communications, Vol 5, Iss 5, Pp 760-773 (2021)
Nonalcoholic steatohepatitis (NASH) is a major cause of liver‐related morbidity and mortality worldwide. Liver fibrosis stage, a key component of NASH, has been linked to the risk of mortality and liver‐related clinical outcomes. Currently there
Externí odkaz:
https://doaj.org/article/8a3abd3b1df443e39f2096123e2609aa
Autor:
Pitchumani Sivakumar, John Ryan Thompson, Ron Ammar, Mary Porteous, Carly McCoubrey, Edward Cantu, Kandasamy Ravi, Yan Zhang, Yi Luo, Denis Streltsov, Michael F. Beers, Gabor Jarai, Jason D. Christie
Publikováno v:
ERJ Open Research, Vol 5, Iss 3 (2019)
Idiopathic pulmonary fibrosis (IPF), the scarring of lung parenchyma resulting in the loss of lung function, remains a fatal disease with a significant unmet medical need. Patients with severe IPF often develop acute exacerbations resulting in the ra
Externí odkaz:
https://doaj.org/article/6fd6b7966811448c83dc2ff77e664ba7
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215565 (2019)
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease affecting ~5 million people globally. We have constructed an accurate model of IPF disease status using elastic net regularized regression on clinical gene expression data.
Externí odkaz:
https://doaj.org/article/3d0c7a16105e4be4a11485f11e78bf2e
Autor:
Natalia Smoktunowicz, Robert E. Alexander, Linda Franklin, Andrew E. Williams, Beverley Holman, Paul F. Mercer, Gabor Jarai, Chris J. Scotton, Rachel C. Chambers
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 9, Pp 1129-1139 (2015)
TGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in a two-hi
Externí odkaz:
https://doaj.org/article/6b013f0de43e4b878df392399dcdb008
Autor:
Mike Petrassi, Rob Barber, Celine Be, Sarah Beach, Brian Cox, Anne-Marie D’Souza, Nick Duggan, Martin Hussey, Roy Fox, Peter Hunt, Gabor Jarai, Takatoshi Kosaka, Paul Oakley, Viral Patel, Neil Press, David Rowlands, Clemens Scheufler, Oliver Schmidt, Honnappa Srinivas, Mary Turner, Rob Turner, John Westwick, Alison Wolfreys, Nuzhat Pathan, Simon Watson, Matthew Thomas
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Pulmonary arterial hypertension (PAH) has demonstrated multi-serotonin receptor dependent pathologies, characterized by increased tone (5-HT1B receptor) and complex lesions (SERT, 5-HT1B, 5-HT2B receptors) of the pulmonary vasculature together with r
Externí odkaz:
https://doaj.org/article/be575ec27b9d4ba3b8e400bbf8ceb145
SOMAscan Proteomics Identifies Serum Biomarkers Associated With Liver Fibrosis in Patients With NASH
Autor:
Gabor Jarai, Abdul M. Oseini, Edgar D. Charles, Diane E. Shevell, Rebecca Collen, Benjamin E. Decato, Samir Wadhawan, John Ryan Thompson, Yi Luo, Alex Greenfield, Arun J. Sanyal
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 5, Iss 5, Pp 760-773 (2021)
Hepatology Communications, Vol 5, Iss 5, Pp 760-773 (2021)
Nonalcoholic steatohepatitis (NASH) is a major cause of liver‐related morbidity and mortality worldwide. Liver fibrosis stage, a key component of NASH, has been linked to the risk of mortality and liver‐related clinical outcomes. Currently there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afda6a128e55dbfb498467095767d72
https://doi.org/10.1002/hep4.1670
https://doi.org/10.1002/hep4.1670
Autor:
Yi Luo, Denis Streltsov, Mary K. Porteous, Carly McCoubrey, Pitchumani Sivakumar, Edward Cantu, Jason D. Christie, Gabor Jarai, John Ryan Thompson, Michael F. Beers, Ron Ammar
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Respiratory Research
Respiratory Research
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a significant unmet medical need. Development of transformational therapies for IPF is challenging in part to due to lack of robust predictive biomarkers of prognosis and tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9608672ed91ae810fbf18a50b068e370
https://doi.org/10.1186/s12931-021-01860-3
https://doi.org/10.1186/s12931-021-01860-3
Autor:
Nicolai A Kittan, Ronald M Allen, Abhay Dhaliwal, Karen A Cavassani, Matthew Schaller, Katherine A Gallagher, William F Carson, Sumanta Mukherjee, Jolanta Grembecka, Tomasz Cierpicki, Gabor Jarai, John Westwick, Steven L Kunkel, Cory M Hogaboam
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78045 (2013)
Macrophages (MΦ) play an essential role in innate immune responses and can either display a pro-inflammatory, classically activated phenotype (M1) or undergo an alternative activation program (M2) promoting immune regulation. M-CSF is used to differ
Externí odkaz:
https://doaj.org/article/aa82d74e1bf24ffa9f824ede7abb0d9b
Autor:
Christine Egger, Catherine Cannet, Christelle Gérard, Elizabeth Jarman, Gabor Jarai, Agnès Feige, Thomas Suply, Arthur Micard, Andrew Dunbar, Bruno Tigani, Nicolau Beckmann
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63432 (2013)
Pulmonary fibrosis can be experimentally induced in small rodents by bleomycin. The antibiotic is usually administered via the intratracheal or intranasal routes. In the present study, we investigated the oropharyngeal aspiration of bleomycin as an a
Externí odkaz:
https://doaj.org/article/197b43e4cb5a4fe384ba6f92725a2730