Current and potential treatments for ubiquitous but neglected herpesvirus infections

Autor: Craik, Charles, Gable, JE, Acker, TM, Craik, CS

Publikováno v: Craik, Charles; Gable, JE; Acker, TM; & Craik, CS. (2014). Current and potential treatments for ubiquitous but neglected herpesvirus infections. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2f094540

A comprehensive review of herpes virus drug discovery with an emphasis on the most recent advances in the field and their progression from early discovery to clinical development is presented. Small molecules against multiple herpes viruses with targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::034ba708b5bfada394687a93b307ddc6
http://www.escholarship.org/uc/item/2f094540

Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.

Autor: Rao SPS; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.; Novartis Institute for Tropical Diseases, Singapore., Gould MK; College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Noeske J; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Saldivia M; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Jumani RS; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Ng PS; Novartis Institute for Tropical Diseases, Singapore., René O; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Chen YL; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.; Novartis Institute for Tropical Diseases, Singapore., Kaiser M; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; Faculty of Science, University of Basel, Basel, Switzerland., Ritchie R; College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Francisco AF; London School of Hygiene and Tropical Medicine, London, UK., Johnson N; Novartis Institute for Tropical Diseases, Emeryville, CA, USA., Patra D; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Cheung H; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Deniston C; Novartis Institutes for BioMedical Research, San Diego, CA, USA., Schenk AD; Novartis Institutes for BioMedical Research, Basel, Switzerland., Cortopassi WA; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Schmidt RS; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; Faculty of Science, University of Basel, Basel, Switzerland., Wiedemar N; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; Faculty of Science, University of Basel, Basel, Switzerland., Thomas B; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Palkar R; Novartis Institute for Tropical Diseases, Emeryville, CA, USA., Ghafar NA; Novartis Institute for Tropical Diseases, Singapore., Manoharan V; Novartis Institute for Tropical Diseases, Singapore., Luu C; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Gable JE; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Wan KF; Novartis Institute for Tropical Diseases, Singapore., Myburgh E; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK., Mottram JC; York Biomedical Research Institute, Department of Biology, University of York, York, UK., Barnes W; Novartis Institutes for BioMedical Research, San Diego, CA, USA., Walker J; Novartis Institutes for BioMedical Research, San Diego, CA, USA., Wartchow C; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Aziz N; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Osborne C; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Wagner J; Novartis Institute for Tropical Diseases, Singapore.; Novartis Institutes for BioMedical Research, Basel, Switzerland., Sarko C; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Kelly JM; London School of Hygiene and Tropical Medicine, London, UK., Manjunatha UH; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.; Novartis Institute for Tropical Diseases, Singapore., Mäser P; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; Faculty of Science, University of Basel, Basel, Switzerland., Jiricek J; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institute for Tropical Diseases, Singapore., Lakshminarayana SB; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.; Novartis Institute for Tropical Diseases, Singapore., Barrett MP; College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Diagana TT; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.; Novartis Institute for Tropical Diseases, Singapore.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Jun 30; Vol. 380 (6652), pp. 1349-1356. Date of Electronic Publication: 2023 Jun 29.

Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.

Autor: Gable JE; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158-2280, USA.; Biophysics Graduate Group, University of California, San Francisco, CA, 94158-2280, USA., Lee GM; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158-2280, USA., Acker TM; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158-2280, USA., Hulce KR; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158-2280, USA.; Chemistry and Chemical Biology Graduate Group, University of California, San Francisco, CA, 94158-2280, USA., Gonzalez ER; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158-2280, USA., Schweigler P; Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, 4002, Basel, Switzerland., Melkko S; Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, 4002, Basel, Switzerland., Farady CJ; Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, 4002, Basel, Switzerland., Craik CS; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158-2280, USA. Charles.Craik@ucsf.edu.

Publikováno v: ChemMedChem [ChemMedChem] 2016 Apr 19; Vol. 11 (8), pp. 862-9. Date of Electronic Publication: 2016 Jan 28.

Broad-spectrum allosteric inhibition of herpesvirus proteases.

Autor: Gable JE; Department of Pharmaceutical Chemistry, University of California , San Francisco, California 94158-2280, United States., Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS

Publikováno v: Biochemistry [Biochemistry] 2014 Jul 22; Vol. 53 (28), pp. 4648-60. Date of Electronic Publication: 2014 Jul 11.

Enzyme inhibition by allosteric capture of an inactive conformation.

Autor: Lee GM; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158-2280, USA., Shahian T, Baharuddin A, Gable JE, Craik CS

Publikováno v: Journal of molecular biology [J Mol Biol] 2011 Sep 02; Vol. 411 (5), pp. 999-1016. Date of Electronic Publication: 2011 Jun 22.