Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gabe Mintier"'
Autor:
Ricardo A. García, PhD, Bruce R. Ito, PhD, John A. Lupisella, MSc, Nancy A. Carson, BSc, Mei-Yin Hsu, MSc, Gayani Fernando, MSc, Madeleine Heroux, PhD, Michel Bouvier, PhD, Elizabeth Dierks, PhD, Ellen K. Kick, PhD, David A. Gordon, PhD, Jian Chen, PhD, Gabe Mintier, BSc, Marilyn Carrier, PhD, Stéphane St-Onge, MSc, Himanshu Shah, MSc, Jordan Towne, BSc, Marcela Sotelo Bucardo, BSc, Xiuying Ma, PhD, Carol S. Ryan, BSc, Nicholas R. Wurtz, PhD, Jacek Ostrowski, PhD, Francisco J. Villarreal, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 905-920 (2019)
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and p
Externí odkaz:
https://doaj.org/article/87187fce26ae464386af76218484bf38
Autor:
Stéphane St-Onge, Bruce R. Ito, John A. Lupisella, Madeleine Héroux, Ricardo Garcia, Marilyn Carrier, Mei-Yin Hsu, Carol S. Ryan, Michel Bouvier, Elizabeth A. Dierks, Nicholas R. Wurtz, Ellen K. Kick, Jian Chen, Nancy A. Carson, Gayani Fernando, Jordan Kelly Towne, Jacek Ostrowski, Francisco Villarreal, Himanshu Shah, Xiuying Ma, Marcela Sotelo Bucardo, Gabe Mintier, David A. Gordon
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 905-920 (2019)
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and p
Autor:
John N. Feder, H. David Inzunza, Diana M. Cardona, John Cogswell, James Novotny, Gabe Mintier, Qiuyan Wu
Publikováno v:
Molecular Diagnosis & Therapy
Aim Nivolumab, a fully human immunoglobulin G4 programmed death-1 (PD-1) immune checkpoint inhibitor antibody, has activity in melanoma, non–small-cell lung cancer (NSCLC), renal cell carcinoma (RCC), and Hodgkin lymphoma. Nivolumab is approved in
Autor:
R. Marcus Fancher, Prasad Krishnamurthy, Tongtong Liu, Xi Qiu, Cliff Chen, Hamza Kandoussi, Kristin Taylor, Sunil Sukrutharaj, Kathy Kuit, Jianing Zeng, Yurong Lai, A. David Rodrigues, Hao Jiang, Gabe Mintier, Craig Titsch, Hong Shen, Punit Marathe
Publikováno v:
Drug Metabolism and Disposition. 44:238-249
Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2K mediate the renal secretion of various cationic drugs and can serve as the loci of drug-drug interactions (DDI). To support the evaluation of cynomolgus mo
Autor:
D Storton, Gabe Mintier, Qi Guo, M Ma-Edmonds, Xuning Wang, D Zhao, John N. Feder, B Kienzle, X Xiao
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Using CRISPR/Cas9 delivered as a RNA modality in conjunction with a lipid specifically formulated for large RNA molecules, we demonstrate that homology directed repair (HDR) rates between 20–40% can be achieved in induced pluripotent stem cells (iP
Autor:
Gabe Mintier, Lun Li, Yurong Lai, Punit Marathe, Ramaswamy A. Iyer, Hong Shen, Marcus Fancher, Hong Su, David Rodrigues, Ming Yao, Tongtong Liu
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 353:380-391
Organic anion transporting polypeptides (OATPs) mediate hepatic drug uptake and serve as the loci of drug-drug interactions (DDIs). Consequently, there is a major need to develop animal models and refine in vitro-in vivo extrapolations. Therefore, th
Autor:
Scott Priestley, Jeffrey Colin, Xuewen Ma, Michel Bouvier, Jacques Banville, Sophie Desmeules, Anne Marinier, Roger Remillard, Fraz A. Ismat, Mario Callejo, Ke Xu, Tao Wang, John N. Feder, Zhaoqing Wang, Gabe Mintier, Chi Sum, Jing Yang
Publikováno v:
Stroke. 47
Introduction: Protease-activated receptor 4 (PAR4) is a platelet thrombin receptor and a novel target for ischemic stroke treatment. Recent reports suggested a subtle racial difference in platelet responses to submaximal concentrations of PAR4 agonis
Autor:
Stefan Kirov, John N. Feder, Xuning Wang, Charles Tilford, Qi Guo, Isaac M. Neuhaus, Gabe Mintier
Publikováno v:
Bioinformatics. 33:3811-3812
Summary The simplicity and precision of CRISPR/Cas9 system has brought in a new era of gene editing. Screening for desired clones with CRISPR-mediated genomic edits in a large number of samples is made possible by next generation sequencing (NGS) due
Autor:
Gabe Mintier, James K. Tamura, Ching-Hsuen Chu, Dong Cheng, Mark R. Harpel, Gregory A. Locke, Yuli Wu, Joseph W. Cook, John N. Feder, Luping Chen, Yongmi An
Publikováno v:
Protein Expression and Purification. 51:11-21
Acetyl coenzyme A (acetyl-CoA) carboxylase isozyme 1 (ACC1) and acetyl-CoA carboxylase isozyme 2 (ACC2) are critical for de novo fatty acid synthesis and for the regulation of beta-oxidation. Emerging evidence indicates that one or both isozymes migh
Autor:
Praveen Balimane, Prasad Krishnamurthy, Sanjith Kallipatti, Punit Marathe, Zheng Yang, Cliff Chen, Sabariya Selvam, Yong-Hae Han, Sunil Sukrutharaj, Gabe Mintier, Hong Shen, Renjie Zhang, Weiping Zhao, Mohammed Jemal, A. David Rodrigues
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 344(3)
Organic anion-transporting polypeptides (OATP) 1B1, 1B3, and 2B1 can serve as the loci of drug-drug interactions (DDIs). In the present work, the cynomolgus monkey was evaluated as a potential model for studying OATP-mediated DDIs. Three cynomolgus m