Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gabe Dezeny"'
Autor:
Hiranthi Jayasuriya, Gabe Dezeny, Mary Motyl, Francisca Vicente, Joann Huber, Angela Basilio, Deborah L. Zink, Kevin M. Byrne, Javier Collado, Sheo B. Singh, Mary Lee Goldman, Gerald F. Bills
Publikováno v:
The Journal of Antibiotics. 62:265-269
Treatment of drug-resistant bacteria is a significant unmet medical need. This challenge can be met only by the discovery and development of new antibiotics. Antisense technology is one of the newest discovery tools that provides enhanced sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4b57cbed74e6656008fc49e60ca6bd
https://doi.org/10.1038/ja.2009.26
https://doi.org/10.1038/ja.2009.26
Autor:
Robert S. Slaughter, John P. Felix, Sheo B. Singh, Deborah L. Zink, Gerald F. Bills, Anne W. Dombrowski, Gabe Dezeny, Michael A. Goetz
Publikováno v:
Organic Letters. 3:247-250
[figure: see text] Blockers of the voltage-gated potassium channel Kv1.3 are potential immunosuppressants. Candelalides A-C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f095a85e8ea13b89c1898d2b8f6c9b6d
https://doi.org/10.1021/ol006891x
https://doi.org/10.1021/ol006891x
Autor:
John G. Ondeyka, Angela Basilio, Gabe Dezeny, Kevin M. Byrne, Sheo B. Singh, Francisca Vicente, Mary Motyl, Maria Teresa Diez, Gerald F. Bills, Deborah L. Zink
Publikováno v:
Journal of Natural Products. 70:668-670
Bacterial protein synthesis inhibitors interact mainly with rRNA and to some extent ribosomal proteins, which are potential targets for developing new antibacterial agents. Specifically, the ribosomal protein S4 of the 30s ribosomal subunit known as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8db1c0ad17add3d5ba2902cde93526a
https://doi.org/10.1021/np060557d
https://doi.org/10.1021/np060557d
Autor:
J. J. Bergan, George B. Smith, David L. Hughes, Edward J. J. Grabowski, Zhiguo Jake Song, Gabe Dezeny, Paul J. Reider
Publikováno v:
Tetrahedron: Asymmetry. 4:865-874
Enzymatic asymmetrization of a prochiral diester having 4 bonds between the ester group and prochiral center is the cornerstone of a short and efficient synthesis of an LTD4 antagonist. The enzymatic hydrolysis occurs in a heterogeneous slurry, but a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087ae95a6bdae92f4b66ed4e0a963fc0
https://doi.org/10.1016/s0957-4166(00)80124-x
https://doi.org/10.1016/s0957-4166(00)80124-x
Autor:
Deborah L. Zink, Robert S. Slaughter, Anne W. Dombrowski, John P. Felix, Jon D. Polishook, Gabe Dezeny, Michael A. Goetz, Sheo B. Singh
Publikováno v:
Tetrahedron Letters. 42:1255-1257
The isolation, structure elucidation and chemical modification of nalanthalide, a novel diterpenoid pyrone blocker of the voltage-gated potassium channel Kv1.3 are reported. The structure–activity relationship of the derivatives with respect to var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434daa37d60de3fb5ac56334927fa60f
https://doi.org/10.1016/s0040-4039(00)02258-9
https://doi.org/10.1016/s0040-4039(00)02258-9
Autor:
J. J. Bergan, Zhiguo Jake Song, George B. Smith, David L. Hughes, Edward J. J. Grabowski, Paul J. Reider, Gabe Dezeny
Publikováno v:
ChemInform. 24
Enzymatic asymmetrization of a prochiral diester having 4 bonds between the ester group and prochiral center is the cornerstone of a short and efficient synthesis of an LTD4 antagonist. The enzymatic hydrolysis occurs in a heterogeneous slurry, but a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f4f74af8f54ff1120bca46fc69182fa
https://doi.org/10.1002/chin.199343073
https://doi.org/10.1002/chin.199343073
Autor:
Jon D. Polishook, Sheo B. Singh, Robert S. Slaughter, Anne W. Dombrowski, John P. Felix, Deborah L. Zink, Gabe Dezeny, Michael A. Goetz
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d41bbdd4f82203c72a0ee2cafe26d0e
https://doi.org/10.1002/chin.200122125
https://doi.org/10.1002/chin.200122125
Autor:
John P. Felix, Deborah L. Zink, Michael A. Goetz, Robert S. Slaughter, Gabe Dezeny, Anne W. Dombrowski, Sheo B. Singh, Gerald F. Bills
Publikováno v:
ChemInform. 32
[figure: see text] Blockers of the voltage-gated potassium channel Kv1.3 are potential immunosuppressants. Candelalides A-C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2ed782fbee9255db90485a76d40f28
https://doi.org/10.1002/chin.200119162
https://doi.org/10.1002/chin.200119162