Novel agonist- and antagonist-based radioligands for the GLP-2 receptor - useful tools for studies of basic GLP-2R pharmacology

Autor: Gadgaard, Sarina, van der Velden, Wijnand J C, Schiellerup, Sine P, Hunt, Jenna Elizabeth, Gabe, Maria B N, Windeløv, Johanne Agerlin, Boer, Geke Aline, Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens J., Hartmann, Bolette, Rosenkilde, Mette M

Publikováno v: Gadgaard, S, van der Velden, W J C, Schiellerup, S P, Hunt, J E, Gabe, M B N, Windeløv, J A, Boer, G A, Kissow, H, Ørskov, C, Holst, J J, Hartmann, B & Rosenkilde, M M 2022, ' Novel agonist-and antagonist-based radioligands for the GLP-2 receptor-useful tools for studies of basic GLP-2R pharmacology ', British Journal of Pharmacology, vol. 179, no. 9, pp. 1998-2015 . https://doi.org/10.1111/bph.15766

BACKGROUND: Glucagon-like peptide-2(GLP-2) is a pro-glucagon-derived hormone secreted from intestinal enteroendocrine L-cells with actions on gut and bones. GLP-2(1-33) is cleaved by the enzyme DPP-4, forming GLP-2(3-33) which has low intrinsic activ

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Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals.

Autor: Gabe, Maria B. N., Gasbjerg, Lærke S., Hartmann, Bolette, Veedfald, Simon, Holst, Jens J., Rosenkilde, Mette M., Sparre-Ulrich, Alexander H., Jensen, Mette H., Helsted, Mads M., Knop, Filip K., Stensen, Signe, Lanng, Amalie R., Vilsbøll, Tina, Bergmann, Natasha C., Christensen, Mikkel B.

Publikováno v: Diabetes; May2019, Vol. 68 Issue 5, p906-917, 12p, 2 Charts, 6 Graphs