ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development.

Autor: Kostina A; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Lewis-Israeli YR; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Abdelhamid M; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Division of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Gabalski MA; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Kiselev A; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, MI, USA; Division of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA., Volmert BD; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Lankerd H; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Huang AR; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Wasserman AH; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Lydic T; Department of Physiology, Michigan State University, MI, USA., Chan C; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA; Division of Biomedical Devices, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA., Park S; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, MI, USA; Division of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA., Olomu I; Division of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Aguirre A; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA. Electronic address: aaguirre@msu.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2024 Mar 12; Vol. 19 (3), pp. 317-330. Date of Electronic Publication: 2024 Feb 08.

ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes.

Autor: Kostina A; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Lewis-Israeli YR; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Abdelhamid M; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Division of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Gabalski MA; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Volmert BD; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Lankerd H; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Huang AR; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Wasserman AH; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Lydic T; Department of Physiology, Michigan State University, MI, USA., Chan C; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA.; Department of Chemical Engineering and Materials Science, Michigan State University, MI, USA., Olomu I; Division of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Aguirre A; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 08. Date of Electronic Publication: 2023 Jun 08.

Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease.

Autor: Lewis-Israeli YR; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Wasserman AH; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Gabalski MA; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Volmert BD; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Ming Y; Department of Biomedical Engineering, Washington University in Saint Louis, St. Louis, MO, USA., Ball KA; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Yang W; Division of Biomedical Devices, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Electrical and Computer Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Zou J; Department of Biomedical Engineering, Washington University in Saint Louis, St. Louis, MO, USA., Ni G; Department of Biomedical Engineering, Washington University in Saint Louis, St. Louis, MO, USA., Pajares N; Department of Chemical Engineering and Material Science, College of Engineering, Michigan State University, East Lansing, MI, USA., Chatzistavrou X; Department of Chemical Engineering and Material Science, College of Engineering, Michigan State University, East Lansing, MI, USA., Li W; Division of Biomedical Devices, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Electrical and Computer Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Zhou C; Department of Biomedical Engineering, Washington University in Saint Louis, St. Louis, MO, USA., Aguirre A; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA. aaguirre@msu.edu.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA. aaguirre@msu.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Aug 26; Vol. 12 (1), pp. 5142. Date of Electronic Publication: 2021 Aug 26.