GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells.

Autor: Gaal, Orsolya I.^1,2 (AUTHOR), Liu, Ruiqi² (AUTHOR), Marginean, Dragoș¹ (AUTHOR), Badii, Medeea^1,2 (AUTHOR), Cabău, Georgiana¹ (AUTHOR), Hotea, Ioana³ (AUTHOR), Nica, Valentin¹ (AUTHOR), Colcear, Doina⁴ (AUTHOR), HINT Consortium (AUTHOR), Joosten, Leo A. B.^1,2 (AUTHOR), Pop, Ioan V.¹ (AUTHOR), Crişan, Tania O.¹ (AUTHOR), Farcaş, Marius¹ (AUTHOR), Marginean, Dragoş H.¹ (AUTHOR), Badii, Medeea O.¹ (AUTHOR), Peca, Loredana¹ (AUTHOR), Mirea, Andreea-Manuela¹ (AUTHOR), Pop, Mariana S.¹ (AUTHOR), Rus, Ancuta¹ (AUTHOR), Pamfil, Cristina³ (AUTHOR)

Publikováno v: Scientific Reports. 2/16/2024, Vol. 14 Issue 1, p1-9. 9p.

A genome-wide association analysis reveals new pathogenic pathways in gout

Autor: Major, Tanya J., Takei, Riku, Matsuo, Hirotaka, Leask, Megan P., Sumpter, Nicholas A., Topless, Ruth K., Shirai, Yuya, Wang, Wei, Cadzow, Murray J., Phipps-Green, Amanda J., Li, Zhiqiang, Ji, Aichang, Merriman, Marilyn E., Morice, Emily, Kelley, Eric E., Wei, Wen-Hua, McCormick, Sally P. A., Bixley, Matthew J., Reynolds, Richard J., Saag, Kenneth G., Fadason, Tayaza, Golovina, Evgenia, O’Sullivan, Justin M., Stamp, Lisa K., Dalbeth, Nicola, Abhishek, Abhishek, Doherty, Michael, Roddy, Edward, Jacobsson, Lennart T. H., Kapetanovic, Meliha C., Melander, Olle, Andrés, Mariano, Pérez-Ruiz, Fernando, Torres, Rosa J., Radstake, Timothy, Jansen, Timothy L., Janssen, Matthijs, Joosten, Leo A. B., Liu, Ruiqi, Gaal, Orsolya I., Crişan, Tania O., Rednic, Simona, Kurreeman, Fina, Huizinga, Tom W. J., Toes, René, Lioté, Frédéric, Richette, Pascal, Bardin, Thomas, Ea, Hang Korng, Pascart, Tristan, McCarthy, Geraldine M., Helbert, Laura, Stibůrková, Blanka, Tausche, Anne-K., Uhlig, Till, Vitart, Véronique, Boutin, Thibaud S., Hayward, Caroline, Riches, Philip L., Ralston, Stuart H., Campbell, Archie, MacDonald, Thomas M., Nakayama, Akiyoshi, Takada, Tappei, Nakatochi, Masahiro, Shimizu, Seiko, Kawamura, Yusuke, Toyoda, Yu, Nakaoka, Hirofumi, Yamamoto, Ken, Matsuo, Keitaro, Shinomiya, Nariyoshi, Ichida, Kimiyoshi, Lee, Chaeyoung, Bradbury, Linda A., Brown, Matthew A., Robinson, Philip C., Buchanan, Russell R. C., Hill, Catherine L., Lester, Susan, Smith, Malcolm D., Rischmueller, Maureen, Choi, Hyon K., Stahl, Eli A., Miner, Jeff N., Solomon, Daniel H., Cui, Jing, Giacomini, Kathleen M., Brackman, Deanna J., Jorgenson, Eric M., Liu, Hongbo, Susztak, Katalin, Shringarpure, Suyash, So, Alexander, Okada, Yukinori, Li, Changgui, Shi, Yongyong, Merriman, Tony R.

Publikováno v: Nature Genetics; November 2024, Vol. 56 Issue: 11 p2392-2406, 15p

TGF-β is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells.

Autor: Klück, Viola, Cabău, Georgiana, Mies, Linda, Bukkems, Femke, van Emst, Liesbeth, Bakker, René, van Caam, Arjan, HINT consortium, Pop, Ioan V., Popp, Radu A., Rednic, Simona, Pamfil, Cristina, Farcaş, Marius, Marginean, Dragoş H., Gaal, Orsolya I., Badii, Medeea O., Hotea, Ioana, Peca, Loredana, Mirea, Andreea-Manuela, Nica, Valentin

Publikováno v: Arthritis Research & Therapy; 2/27/2023, Vol. 25 Issue 1, p1-12, 12p