Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI

Autor: Frédérique Depierreux, Eric Parmentier, Laurane Mackels, Katherine Baquero, Christian Degueldre, Evelyne Balteau, Eric Salmon, Christophe Phillips, Mohamed Ali Bahri, Pierre Maquet, Gaëtan Garraux

Publikováno v: npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-10 (2021)

Abstract Parkinson’s disease (PD) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (NM)-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How regional NM loss and iron accum

Externí odkaz: https://doaj.org/article/0946553028454154b53ef1778f32be08

Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[18F]fluoro-L-m-tyrosine imaging and motor performances analysis

Autor: Guillaume Becker, Tania Deprez, Mohamed Ali Bahri, Alain Plenevaux, Fabian Hustadt, Christian Lemaire, Georges Mairet-Coello, Anne Michel, Catherine De Wolf, Lucas Jacquin, Eric Gillent, Aline Freyssin, Martin Citron, Erwan Bezard, Mélina Caruso, Jean-Marie Frequin, André Luxen, Gaëtan Garraux, Patrick Downey

Publikováno v: Neurobiology of Aging. 107:142-152

With the emergence of disease-modifying therapies for Parkinson's disease, reliable longitudinal markers are needed to quantify pathology and demonstrate disease progression. We developed the A53T-AAV rat model of synucleinopathy by combining longitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2d97855b19689590e7d238ba49b7a74
https://doi.org/10.1016/j.neurobiolaging.2021.07.012

Biased binomial assessment of cross-validated estimation of classification accuracies illustrated in diagnosis predictions

Autor: Quentin Noirhomme, Damien Lesenfants, Francisco Gomez, Andrea Soddu, Jessica Schrouff, Gaëtan Garraux, André Luxen, Christophe Phillips, Steven Laureys

Publikováno v: NeuroImage: Clinical, Vol 4, Iss C, Pp 687-694 (2014)

Multivariate classification is used in neuroimaging studies to infer brain activation or in medical applications to infer diagnosis. Their results are often assessed through either a binomial or a permutation test. Here, we simulated classification r

Externí odkaz: https://doaj.org/article/01e67d73dcce40cd8a76e9664d0f8416

International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease

Autor: Odile A. van den Heuvel, Reinhold Schmidt, Boris A. Gutman, Daniel Weintraub, Corey T. McMillan, Gianfranco Spalletta, Ines Debove, Tim J. Anderson, Max A. Laansma, Petra Schwingenschuh, Cristiane S. Rocha, Tracy R. Melzer, Francesca Assogna, John C. Dalrymple-Alford, Mario Rango, Michiel F. Dirkx, Lucas S.R. Santos, Laura M. Parkes, Rachel Guimaraes, Hedley C. A. Emsley, Toni L. Pitcher, Roland Wiest, Fernando Cendes, Henk W. Berendse, Clarissa L. Yasuda, Gaëtan Garraux, Joanna Bright, Jiun-Jie Wang, Neda Jahanshad, Johannes C. Klein, Katherine Baquero, Tyler Ard, Ysbrand D. van der Werf, Sarah Al-Bachari, Jamie C. Blair, Rick C. Helmich, Fabrizio Piras, Chris Vriend, Jason Druzgal, Letizia Squarcina, Paul M. Thompson, Kathleen L. Poston, Clare E. Mackay, Rob M.A. de Bie, Christian Rummel, Letícia F. Ribeiro

Publikováno v: Movement Disorders, 36, 11, pp. 2583-2594
Laansma, M A, Bright, J K, Al-Bachari, S, Anderson, T J, Ard, T, Assogna, F, Baquero, K A, Berendse, H W, Blair, J, Cendes, F, Dalrymple-Alford, J C, de Bie, R M A, Debove, I, Dirkx, M F, Druzgal, J, Emsley, H C A, Garraux, G, Guimarães, R P, Gutman, B A, Helmich, R C, Klein, J C, Mackay, C E, McMillan, C T, Melzer, T R, Parkes, L M, Piras, F, Pitcher, T L, Poston, K L, Rango, M, Ribeiro, L F, Rocha, C S, Rummel, C, Santos, L S R, Schmidt, R, Schwingenschuh, P, Spalletta, G, Squarcina, L, van den Heuvel, O A, Vriend, C, Wang, J-J, Weintraub, D, Wiest, R, Yasuda, C L, Jahanshad, N, Thompson, P M, van der Werf, Y D & ENIGMA-Parkinson's Study 2021, ' International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease ', Movement Disorders, vol. 36, no. 11, pp. 2583-2594 . https://doi.org/10.1002/mds.28706
Movement disorders, 36(11), 2583-2594. John Wiley and Sons Inc.
Movement Disorders, 36, 2583-2594
Laansma, Max A; Bright, Joanna K; Al-Bachari, Sarah; Anderson, Tim J; Ard, Tyler; Assogna, Francesca; Baquero, Katherine A; Berendse, Henk W; Blair, Jamie; Cendes, Fernando; Dalrymple-Alford, John C; de Bie, Rob M A; Debove, Ines; Dirkx, Michiel F; Druzgal, Jason; Emsley, Hedley C A; Garraux, Gäetan; Guimarães, Rachel P; Gutman, Boris A; Helmich, Rick C; ... (2021). International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease. Movement disorders, 36(11), pp. 2583-2594. Wiley-Blackwell 10.1002/mds.28706
Movement Disorders, 36(11), 2583-2594. John Wiley and Sons Inc.

Contains fulltext : 244253.pdf (Publisher’s version ) (Open Access) BACKGROUND: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. OBJECTIVE: Using a multicenter approach and harmonized analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707e35303cd44469d03b9f797ac31f63
https://repository.ubn.ru.nl/handle/2066/244253

Evidence for a role of a cortico-subcortical network for automatic and unconscious motor inhibition of manual responses.

Autor: Kevin D'Ostilio, Fabienne Collette, Christophe Phillips, Gaëtan Garraux

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e48007 (2012)

It is now clear that non-consciously perceived stimuli can bias our decisions. Although previous researches highlighted the importance of automatic and unconscious processes involved in voluntary action, the neural correlates of such processes remain

Externí odkaz: https://doaj.org/article/e493cf5efb3548c6ad083044bb5fa04e