Dual MGMT inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma

Autor: Sophie Richard, Gaëlle Tachon, Serge Milin, Michel Wager, Lucie Karayan‐Tapon

Publikováno v: Cancer Medicine, Vol 9, Iss 17, Pp 6344-6353 (2020)

Abstract Background Epigenetic inactivation of O6‐methylguanine‐methyltransferase (MGMT) gene by methylation of its promoter is predictive of Temozolomid (TMZ) response in glioblastoma (GBM). MGMT is located on chromosome 10q26 and the loss of ch

Externí odkaz: https://doaj.org/article/379d796c9efa44ef9e38e62e58184717

Impact de la méthode de segmentation dans la caractérisation des adénocarcinomes pulmonaires en TEP-TDM au 18FDG

Autor: Gaëlle Tachon, C. Cheze-Le-Rest, R. Perdrisot, M. Berraho, L. Karayan-Tapon, Olena Tankyevych, A. Dambrain

Publikováno v: Médecine Nucléaire. 45:13-18

Resume Objectif Le traitement des adenocarcinomes pulmonaires est conditionne par la presence de certaines anomalies genetiques. Certains parametres quantitatifs en TEP-TDM au 18FDG permettant, a l’echelle des voxels, de caracteriser la forme et la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f351eae6557462f5de721dae79ed5192
https://doi.org/10.1016/j.mednuc.2020.03.003

Standardisation of pathogenicity classification for somatic alterations in solid tumours and haematologic malignancies

Autor: Laurent Miguet, Florence Coulet, Celine Guien, Lucie Karayan-Tapon, Isabelle Soubeyran, Anne Cayre, Laurent Mauvieux, Etienne Muller, Karen Leroy, Alexandre Harlé, Christophe Béroud, Olfa Trabelsi Grati, Pierre Sujobert, Etienne Rouleau, Alexandra Lespagnol, Gaëlle Tachon, Florence Koeppel, Claude Preudhomme, David Salgado, Olivier Kosmider

Publikováno v: European Journal of Cancer
European Journal of Cancer, 2021, 159, pp.1-15. ⟨10.1016/j.ejca.2021.08.047⟩
European Journal of Cancer, Elsevier, 2021, 159, pp.1-15. ⟨10.1016/j.ejca.2021.08.047⟩

International audience; Background: The difficulty in interpreting somatic alterations is correlated with the increase in sequencing panel size. To correctly guide the clinical management of patients with cancer, there needs to be accurate classifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0543125e44b1e51aec427352cd59511
https://hal.science/hal-03408473

Heterogeneity of Mismatch Repair Status and Microsatellite Instability between Primary Tumour and Metastasis and Its Implications for Immunotherapy in Colorectal Cancers

Autor: Camille Evrard, Stéphane Messina, David Sefrioui, Éric Frouin, Marie-Luce Auriault, Romain Chautard, Aziz Zaanan, Marion Jaffrelot, Christelle De La Fouchardière, Thomas Aparicio, Romain Coriat, Julie Godet, Christine Silvain, Violaine Randrian, Jean-Christophe Sabourin, Rosine Guimbaud, Elodie Miquelestorena-Standley, Thierry Lecomte, Valérie Moulin, Lucie Karayan-Tapon, Gaëlle Tachon, David Tougeron

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4427

Deficient mismatch repair system (dMMR)/microsatellite instability (MSI) is found in about 5% of metastatic colorectal cancers (mCRCs) with a major therapeutic impact for immune checkpoint inhibitor (ICI) use. We conducted a multicentre study includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292a7c59a344ba1069eed0ea70a3c363
https://doi.org/10.3390/ijms23084427

Fatal correlation between YAP1 expression and glioma aggressiveness: clinical and molecular evidence

Autor: Julie Godet, Lucie Karayan-Tapon, Gaëlle Tachon, Serge Milin, Christos Petropoulos, Delphine Larrieu, Pierre-Olivier Guichet, Michel Wager, Konstantin Masliantsev

Publikováno v: The Journal of Pathology. 246:205-216

During the last decade, large-scale genomic analyses have clarified the somatic alterations in gliomas, providing new molecular classification based on IDH1/2 mutations and 1p19q codeletion with more accurate patient prognostication. The Hippo pathwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2cca27eea7c805f8a0316106a8495de
https://doi.org/10.1002/path.5133