Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gaëlle S. Kolly"'
Autor:
János Pató, Jan Rybniker, Gaëlle S. Kolly, Rita Székely, Neeraj Dhar, Zuzana Palčeková, Anthony Vocat, Digby F. Warner, Júlia Zemanová, Monica G Rengifo, Priscille Brodin, John D. McKinney, Adrian Suarez Covarrubias, Vinayak Singh, François Signorino-Gelo, Joseph Buechler, Sherry L. Mowbray, Ruben C. Hartkoorn, José A. Aínsa, Stewart T. Cole, Vincent Delorme, Martin Forbak, Isabella Santi, Joanna C. Evans, Liliana Rodrigues, György Kéri, Katarína Mikušová, Kai Johnsson, Jana Korduláková, Graham Knott, Valerie Mizrahi
Publikováno v:
Molecular Microbiology. 103:13-25
There is an urgent need to discover new anti-tubercular agents with novel mechanisms of action in order to tackle the scourge of drug-resistant tuberculosis. Here, we report the identification of such a molecule - an AminoPYrimidine-Sulfonamide (APYS
GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis
Autor:
Raju Mukherjee, Gaëlle S. Kolly, Matteo Dal Peraro, Katarína Mikušová, Emoeke Kilacskova, Mahé Raccaud, Luciano A. Abriata, Claudia Sala, Jaroslav Blaško, Stewart T. Cole
Publikováno v:
Journal of bacteriology
Mycobacterium tuberculosis possesses a thick and highly hydrophobic cell wall principally composed of a mycolyl-arabinogalactan-peptidoglycan complex, which is critical for survival and virulence. DprE1 is a well-characterized component of decaprenyl
Autor:
Vadim Makarov, Antonio Carta, Maria Rosalia Pasca, Vincent Delorme, Gaëlle S. Kolly, Claudia Binda, Stewart T. Cole, Alessio Porta, Florence Pojer, Ramakrishna Gadupudi, Priscille Brodin, Ana Luisa de Jesus Lopes Ribeiro, Giuseppe Zanoni, Neeraj Dhar, Laurent R. Chiarelli, Valérie Landry, Svetlana Savina, Rosaria Luciani, Edda De Rossi, Davide Salvatore Francesco Farina, Giorgia Mori, Maria Paola Costi, Stefania Ferrari, Elisabetta Molteni, Alberto Venturelli, Giovanna Riccardi, João Neres, Puneet Saxena, Ruben C. Hartkoorn
Publikováno v:
ACS Chemical Biology. 10:705-714
Phenotypic screening of a quinoxaline library against replicating Mycobacterium tuberculosis led to the identification of lead compound Ty38c (3-((4-methoxybenzyl)amino)-6-(trifluoromethyl)quinoxaline-2-carboxylic acid). With an MIC99 and MBC of 3.1
Publikováno v:
FEMS Microbiology Letters. 358:30-35
Improved genetic tools are required to identify new drug targets in Mycobacterium tuberculosis. To this aim, genetic approaches, targeting either transcription and/or protein degradation, have been developed to appraise gene essentiality and to test
Autor:
Stewart T. Cole, Pia Hartmann, Jan Rybniker, Florence Pojer, Gaëlle S. Kolly, Edeltraud van Gumpel, Jeffrey M. Chen, Jan Marienhagen
Publikováno v:
Biochemical journal 459(3), 467-478 (2014). doi:10.1042/BJ20130732
The Biochemical journal
The Biochemical journal
The complex multiprotein systems for the assembly of protein-bound iron–sulfur (Fe–S) clusters are well defined in Gram-negative model organisms. However, little is known about Fe–S cluster biogenesis in other bacterial species. The ISC (iron
Autor:
Stewart T. Cole, Gaëlle S. Kolly, Neeraj Dhar, John D. McKinney, Francesca Boldrin, Claudia Sala, Ruben C. Hartkoorn, Marcello Ventura, Agnese Serafini, Riccardo Manganelli
Publikováno v:
Molecular Microbiology. 92:194-211
In Mycobacterium tuberculosis the decaprenyl-phospho-d-arabinofuranose (DPA) pathway is a validated target for the drugs ethambutol and benzothiazinones. To identify other potential drug targets in the pathway, we generated conditional knock-down mut
Autor:
Stewart T. Cole, Benoit Lechartier, João Neres, Andréanne Lupien, Claudia Sala, Jérémie Piton, Jan Rybniker, Stefanie Boy-Röttger, Gaëlle S. Kolly, Caroline S. Foo
Publikováno v:
Antimicrobial agents and chemotherapy. 60(11)
Benzothiazinones (BTZs) are a class of compounds found to be extremely potent against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. The potency of BTZs is explained by their specificity for their target decaprenylphosph
Autor:
Gaëlle S, Kolly, Francesca, Boldrin, Claudia, Sala, Neeraj, Dhar, Ruben C, Hartkoorn, Marcello, Ventura, Agnese, Serafini, John D, McKinney, Riccardo, Manganelli, Stewart T, Cole
Publikováno v:
Molecular microbiology. 92(1)
In Mycobacterium tuberculosis the decaprenyl-phospho-d-arabinofuranose (DPA) pathway is a validated target for the drugs ethambutol and benzothiazinones. To identify other potential drug targets in the pathway, we generated conditional knock-down mut
Autor:
Zuzana Svetlíková, Gaëlle S. Kolly, Anisha Ambady, Agnese Serafini, Ming Zhang, K. G. Vishwas, Stewart T. Cole, Sudha Ravishankar, Claudia Sala, Marcelo E. Guerin, Jana Korduláková, Neeraj Dhar, Riccardo Manganelli, Marcello Ventura, Katarína Mikušová, Francesca Boldrin, Naveen Kumar, Giulia Degiacomi, Giorgio Palù
Publikováno v:
Journal of Bacteriology. 196:4197-4197
Reference EPFL-ARTICLE-204012doi:10.1128/Jb.02332-14View record in Web of Science Record created on 2014-12-30, modified on 2017-05-12
Autor:
Ruben C. Hartkoorn, Anthony Vocat, Katarína Mikušová, Elena Kazakova, João Neres, Trent M. Conroy, O. B. Ryabova, Jérémie Piton, Michal Šarkan, Vadim Makarov, Stanislav Huszár, Gaëlle S. Kolly, Stewart T. Cole
8-Nitro-benzothiazinones (BTZs), such as BTZ043 and PBTZ169, inhibit decaprenylphosphoryl-β- d -ribose 2′-oxidase (DprE1) and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro . Structure-activity relationship (SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30730f59186b1402cb4ef1f895a65322
https://infoscience.epfl.ch/record/213880
https://infoscience.epfl.ch/record/213880