Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype

Autor: Irina Fonseca, Cíntia Horta, Ana Sofia Ribeiro, Barbara Sousa, Gaëlle Marteil, Mónica Bettencourt-Dias, Joana Paredes

Publikováno v: Cell Death and Disease, Vol 14, Iss 2, Pp 1-12 (2023)

Abstract Polo-like kinase 4 (Plk4), the major regulator of centriole biogenesis, has emerged as a putative therapeutic target in cancer due to its abnormal expression in human carcinomas, leading to centrosome number deregulation, mitotic defects and

Externí odkaz: https://doaj.org/article/0219254cd3364235a1c703b0b1589e7c

Polo-like kinase 4 (Plk4) potentiatesanoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype

Autor: Irina Fonseca, Cíntia Horta, Ana Sofia Ribeiro, Barbara Sousa, Gaëlle Marteil, Mónica Bettencourt-Dias, Joana Paredes

Polo-like kinase 4 (Plk4), the major regulator of centriole biogenesis, has emerged as a putative therapeutic target in cancer due to its abnormal expression in human carcinomas, leading to centrosome number deregulation, mitotic defects and chromoso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c461bae308b60b4bb8bf4b6c9ee5a8c9
https://doi.org/10.1101/2022.12.16.520613

Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

Autor: Joana Paredes, Nuno L. Barbosa-Morais, Adán Guerrero, Nuno Pimpão Martins, Marta Mesquita, Irina S. Fonseca, Pedro Machado, Gaëlle Marteil, Swadhin Chandra Jana, Mónica Bettencourt-Dias, Susana Mendonça, Maria E. Francia, Bernardo P. de Almeida, Katharina Santos das Dores, Erin M. Tranfield, Susana A. Godinho, Beth Villarreal, André Filipe Vieira, David Pellman

Publikováno v: Nature Communications
Nature Communications, 2018, 9 (1), pp.1258. ⟨10.1038/s41467-018-03641-x⟩
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1258. ⟨10.1038/s41467-018-03641-x⟩

Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a6d30c684697ec94e444456daa5f50
https://hal.science/hal-01939139/file/s41467-018-03641-x.pdf

Discovery of novel mechanisms of centrosome amplification and their therapeutic value in cancer: PS155

Autor: Gaëlle Marteil, Nuno L. Barbosa-Morais, Mónica Bettencourt-Dias, B. P. de Almeida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544fd8dbbc3e7f853f673ce3ca9eccb8
https://europepmc.org/articles/PMC6806836/

Investigating the in Vitro Thermal Stability and Conformational Flexibility of Estrogen Receptors as Potential Key Factors of Their in Vivo Activity

Autor: Gwenaëlle André-Leroux, Hélène Duval, Gaëlle Marteil, Olivier Sire, Véronique Le Tilly, Adélaïde Le Grand

Publikováno v: Biochemistry
Biochemistry, American Chemical Society, 2015, 54 (25), pp.3890-900. ⟨10.1021/acs.biochem.5b00026⟩
Biochemistry 25 (54), 3890-900. (2015)
Biochemistry, 2015, 54 (25), pp.3890-900. ⟨10.1021/acs.biochem.5b00026⟩

International audience; Among hormone-inducible transcription factors, estrogen receptors (ERs) play important roles in tissue growth and differentiation, via either direct or indirect binding, in the nucleus, to specific DNA targets called estrogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f011c014bf1ab66dc9acec090ffe9a
https://hal.inrae.fr/hal-02635430