Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gaëlle Magliocco"'
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1482-1491 (2022)
Abstract The suitability of the endogenous 6‐hydroxymelatonin/melatonin urinary metabolic ratio as a surrogate for the paraxanthine/caffeine ratio to predict cytochrome P450 1A2 (CYP1A2) activity was assessed in this study. Twelve healthy volunteer
Externí odkaz:
https://doaj.org/article/2a4a61b8ead44dafb5e4ad598e3242ba
Publikováno v:
Toxicologie Analytique et Clinique. 35:S24-S25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6a0d23c3bc287219d8a3cb39ff1fd8c
https://doi.org/10.1016/j.toxac.2023.03.030
https://doi.org/10.1016/j.toxac.2023.03.030
Autor:
Gaëlle Magliocco, Youssef Daali
Publikováno v:
Expert Review of Clinical Pharmacology, Vol. 13, No 7 (2020) pp. 671-674
From birth, children may need to take medication for acute or chronic diseases. Antibiotics, anti-asthmatic drugs, antihistamines, analgesics, gastrointestinal drugs and attention-deficit/hyperacti...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25db21c7a16289b373b33621f1cc98d5
https://doi.org/10.1080/17512433.2020.1779057
https://doi.org/10.1080/17512433.2020.1779057
Autor:
Jean-Luc Wolfender, Yvonne Gloor, Alain Matthey, Aurélien Thomas, Emerson Ferreira Queiroz, Jules Alexandre Desmeules, Timothée Joye, Laurence Marcourt, Gaëlle Magliocco, Youssef Daali, Luis M. Quirós-Guerrero, Nasim Bararpour
Publikováno v:
British journal of pharmacology, vol. 178, no. 23, pp. 4708-4725
Background and purpose Individualized assessment of cytochrome P450 2D6 (CYP2D6) activity is usually performed through phenotyping following administration of a probe drug to measure the enzyme's activity. In order to avoid any iatrogenic harm (aller
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657589cdb8ebe96f9ec00f9256ca0521
https://serval.unil.ch/notice/serval:BIB_8116E84FC609
https://serval.unil.ch/notice/serval:BIB_8116E84FC609
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 1181, pp. 122938
For the quantification of the pineal hormone melatonin and its metabolite, 6-hydroxymelatonin, in human overnight urine, a single accurate method by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed. Urine samples were deco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02284b823ac05918c3d9e495f76cc35
https://serval.unil.ch/resource/serval:BIB_5CDFB8562D73.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_5CDFB8562D73.P001/REF.pdf
Publikováno v:
Clinical Pharmacokinetics (2019)
Drug response is subject to an important within- and between-individual variability owing, mainly, to pharmacokinetic and pharmacodynamic factors. Pharmacokinetics includes metabolism by cytochrome P450 (CYP450), major enzymes of phase I reactions th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1e5b6d3e25df64b4aa224baa224cdf
https://doi.org/10.1007/s40262-019-00783-z
https://doi.org/10.1007/s40262-019-00783-z
Autor:
Jules Alexandre Desmeules, Gaëlle Magliocco, Aurélien Thomas, Youssef Daali, Marija Bosilkovska
Publikováno v:
Journal of personalized medicine, vol. 11, no. 2, pp. 150
Journal of Personalized Medicine
Volume 11
Issue 2
Journal of Personalized Medicine, Vol 11, Iss 150, p 150 (2021)
Journal of Personalized Medicine
Volume 11
Issue 2
Journal of Personalized Medicine, Vol 11, Iss 150, p 150 (2021)
In this study, we assessed the potential use of the 1β-hydroxy-deoxycholic acid (1β-OH-DCA) to deoxycholic acid (DCA) urinary metabolic ratio (UMR) as a CYP3A metric in ten male healthy volunteers. Midazolam (MDZ) 1 mg was administered orally at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4246a22ec882db85cb311a57a6999c72
https://serval.unil.ch/resource/serval:BIB_8186FF4285F1.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_8186FF4285F1.P001/REF.pdf
METABOLOMICS REVEALS FIVE ENDOGENOUS BIOMARKERS IN HUMAN URINE AND PLASMA TO PREDICT CYP2D6 ACTIVITY
Autor:
Jules Alexandre Desmeules, Yvonne Gloor, Nasim Bararpour, Youssef Daali, Timothée Joye, Aurélien Thomas, Gaëlle Magliocco, Alain Matthey
Background and Purpose: Individualized assessment of the activity of cytochrome P450 2D6 (CYP2D6), a highly variable drug-metabolizing enzyme, is performed through phenotyping during which a probe drug is administered to measure the enzyme’s activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d2dd08590b198a447f499f023f92a0
https://doi.org/10.22541/au.161131999.93984863/v1
https://doi.org/10.22541/au.161131999.93984863/v1
Publikováno v:
Basic & Clinical Pharmacology & Toxicology
Basic & Clinical Pharmacology & Toxicology, Vol. 128, No 4 (2021) pp. 621-624
Basic & Clinical Pharmacology & Toxicology, Vol. 128, No 4 (2021) pp. 621-624
Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) at the end of 2019, no vaccine has been approved to counter this infection and the available treatments are mainly directed against the immune pathology cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e506911e7ebeb3f5e0ac2201c96d0ed3
https://pubmed.ncbi.nlm.nih.gov/33232578
https://pubmed.ncbi.nlm.nih.gov/33232578
Autor:
Youssef Daali, Gaëlle Magliocco, Caroline Flora Samer, Jules Alexandre Desmeules, Frédérique Rodieux
Publikováno v:
Pediatric Research (2019)
The activity of drug-metabolizing enzymes (DME) shows high inter- and intra-individual variability. Genetic polymorphisms, exposure to drugs, and environmental toxins are known to significantly alter DME expression. In addition, the activity of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336c0c67fca906a879182f3d8586a6b2
https://archive-ouverte.unige.ch/unige:128193
https://archive-ouverte.unige.ch/unige:128193