Impaired brain glucose metabolism as a biomarker for evaluation of dodecyl creatine ester in creatine transporter deficiency: Insights from patient brain-derived organoids and in vivo [18F]FDG PET imaging in a mouse model

Autor: Clémence Disdier, Amélie Soyer, Léa Broca-Brisson, Sébastien Goutal, Anne-Cécile Guyot, Nora Ziani, Louise Breuil, Alexandra Winkeler, Gaëlle Hugon, Thomas Joudinaud, Henri Bénech, Jean Armengaud, Matthew R. Skelton, Rania Harati, Rifat A. Hamoudi, Nicolas Tournier, Aloïse Mabondzo

Publikováno v: Neurobiology of Disease, Vol 202, Iss , Pp 106720- (2024)

Creatine transporter deficiency (CTD) is an inborn error of creatine (Cr) metabolism in which Cr is not properly distributed to the brain due to a mutation in the Cr transporter (CrT) SLC6A8 gene. CTD is associated with developmental delays and with

Externí odkaz: https://doaj.org/article/bde823f812f9471790485c819bd60d17

Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [11C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier

Autor: Louise Breuil, Nora Ziani, Sarah Leterrier, Gaëlle Hugon, Fabien Caillé, Viviane Bouilleret, Charles Truillet, Maud Goislard, Myriam El Biali, Martin Bauer, Oliver Langer, Sébastien Goutal, Nicolas Tournier

Publikováno v: Pharmaceutics, Vol 14, Iss 12, p 2650 (2022)

[11C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are often treated with cytochrome (CYP) modulators which may i

Externí odkaz: https://doaj.org/article/e65cab58e713472f90382c0f7d93f2af

Impact of Donepezil on Brain Glucose Metabolism Assessed Using [

Autor: Gaëlle, Hugon, Sébastien, Goutal, Marie, Sarazin, Michel, Bottlaender, Fabien, Caillé, Marine, Droguerre, Mathieu, Charvériat, Alexandra, Winkeler, Nicolas, Tournier

Publikováno v: Frontiers in neuroscience. 16

Translational methods are needed to monitor the impact of the Alzheimer's disease (AD) and therapies on brain function in animal models and patients. The formation of amyloid plaques was investigated using [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87c9e6c26b526f12f0dd867c41665847
https://pubmed.ncbi.nlm.nih.gov/35281502

[18F]2-fluoro-2-deoxy-sorbitol PET Imaging for Quantitative Estimation of Blood-brain Barrier Permeability in vivo

Autor: Louise Breuil, Anthony Novell, Ambre Dauba, Alexandra Winkeler, Nicolas Tournier, Sébastien Goutal, Gaëlle Hugon

Purpose The non-transported and non-metabolized sorbitol derivative [18F]2-fluoro-2-deoxy-sorbitol ([18F]FDS) can be straightforwardly obtained from chemical reduction of commercial [18F]2-deoxy-2-fluoro-D-glucose. [18F]FDS was evaluated as a small-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a17ca2431966074bc55c41d3ac5603a
https://doi.org/10.21203/rs.3.rs-693599/v1

Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!

Autor: Caroline Bouillot, Radu Bolbos, Thierry Billard, Luc Zimmer, Gaëlle Hugon, Jean-Baptiste Langlois, Biao Li, Frédéric Bonnefoi, Min Zhang, Fabien Chauveau

Publikováno v: Contrast Media and Molecular Imaging
Contrast Media and Molecular Imaging, Wiley, 2019, 2019, pp.9294586. ⟨10.1155/2019/9294586⟩
Contrast Media & Molecular Imaging, Vol 2019 (2019)
Contrast Media and Molecular Imaging, 2019, 2019, pp.9294586. ⟨10.1155/2019/9294586⟩
Contrast Media & Molecular Imaging

The observation that amyloid radiotracers developed for Alzheimer’s disease bind to cerebral white matter paved the road to nuclear imaging of myelin in multiple sclerosis. The lysolecithin (lysophosphatidylcholine (LPC)) rat model of demyelination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ec6372f48834bcace085f2cc06ca3d