Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gaëlle Guiewi Makafe"'
Autor:
Gaëlle Guiewi Makafe, Jinghua Wu, Zhijian Yi, Jiaxin Liu, Qiongxin Liang, Ning Xu, Lingwen Zeng, Zhiyuan Li, Omar Mukama, Yujie Liu, Yumei Liu, Xuewen Lu, Muzammal Hussain
Publikováno v:
Biosensorsbioelectronics. 159
CRISPR/Cas systems have displayed remarkable potential in developing novel biosensing applications for nucleic acid detection owing to the collateral cleavage activity of Cas effector proteins (Cas12, Cas13, etc.). Despite tremendous progress in rece
Autor:
Yaoju Tan, Tianyu Zhang, Xinjie Li, Shouyong Tan, Bangxing Wang, Jianxiong Liu, Changwei Wang, Wing Wai Yew, Gift Chiwala, Julius Mugweru, Gaëlle Guiewi Makafe
Publikováno v:
Infection and Drug Resistance. 11:891-894
Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis (TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic information on the modes of sensitivity and resistance of isoniazid (INH) and ETA warr
Autor:
Yaoju Tan, Zhili Lu, Huofeng Jiang, Cuiting Fang, Yang Zhou, Muzammal Hussain, Shouyong Tan, Zhijun Yu, Jinsong Liu, Gaëlle Guiewi Makafe, Yunxiang Tang, Chiwala Gift, Goverdhan Surineni, Tianyu Zhang, Mugweru Julius, Jianxiong Liu, Zhiyong Liu, Qiang Zhu, Jiancun Zhang, Lanying Liu, Nai-Kei Wong
Publikováno v:
Cell chemical biology. 26(8)
There is a great need for identification and development of new anti-tuberculosis drugs with novel targets. Recent drug-discovery efforts typically focus on identifying inhibitors but not activators that perturb metabolic enzymes' functions as a mean
Autor:
Huofeng Jiang, Yang Liu, Tianyu Zhang, Jianxiong Liu, Zhiyong Liu, Gift Chiwala, Shouyong Tan, Yamin Gao, Gaëlle Guiewi Makafe, Shuai Wang, Mahmudul Islam, Yaoju Tan, Xingshan Cai, Zhili Lu, Chiranjibi Chhotaray, H.M. Adnan Hameed, Xinjie Li, Changwei Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
Buruli ulcer (BU) is an emerging infectious disease that causes disfiguring skin ulcers. The causative agent, Mycobacterium ulcerans, secretes toxin called mycolactone that triggers inflammation and immunopathology. Existing treatments are lengthy an
Autor:
Julius Mugweru, Moses Njire, Bangxing Wang, Yuanyuan Cao, Yaoju Tan, Yang Zhang, Huang Shaobo, Gaëlle Guiewi Makafe, Jianxiong Liu, Tianyu Zhang, Shouyong Tan, Xinjie Li, Jiao-Yu Deng, Chiranjibi Chhotaray
Publikováno v:
Frontiers in Microbiology
The genetic manipulation of Mycobacterium tuberculosis genome is limited by the availability of selection markers. Spontaneous resistance mutation rate of M. tuberculosis to the widely used kanamycin is relatively high which often leads to some false
Autor:
Emmanuel Mouafo Tekwu, Matthias Frank, Jean-Claude Tedom, Christopher Kuaban, Serges Tchatchouang, Francine Ntoumi, Anne-Laure Tchokote Wetewale, Gaëlle Guiewi Makafe, Larissa Kamgue Sidze, Jean-Paul Assam Assam, Sara Eyangoh, Véronique Penlap Beng
Publikováno v:
BMC Microbiology
Background The potential of genetic testing to rapidly diagnose drug resistance has lead to the development of new diagnostic assays. However, prior to implementation in a given setting, the association of specific mutations with specific drug resist