Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gaëlle Gillet"'
Autor:
Manisha Padmakumar, Steven Biesmans, Jorge S. Valadas, Jan R. Detrez, Gaëlle Gillet, Priscillia Bresler, Marie-Laure Clénet, Irena Kadiu
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Neuroscience drug discovery has faced significant challenges due to restricted access to relevant human cell models and limited translatability of existing preclinical findings to human pathophysiology. Induced pluripotent stem cells (iPSCs) have eme
Externí odkaz:
https://doaj.org/article/4e10a82de23d46c7890710e9bc03d4d9
Autor:
Marie-Laure Clénet, James Keaney, Gaëlle Gillet, Jorge S. Valadas, Julie Langlois, Alvaro Cardenas, Julien Gasser, Irena Kadiu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death. In diseases characterized by non-cell autonomo
Externí odkaz:
https://doaj.org/article/8ebc97ff867d42c99a352b940efac384
Publikováno v:
Journal of Neuroimmune Pharmacology
Bruton's tyrosine kinase (BTK), a critical component of B cell receptor signaling, has recently been implicated in regulation of the peripheral innate immune response. However, the role of BTK in microglia, the resident innate immune cells of the cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9811b088aab27260bf7c21e7e51d8c7
https://doi.org/10.1007/s11481-019-09839-0
https://doi.org/10.1007/s11481-019-09839-0
Autor:
David T. Scadden, Menglu Qian, Joanie Mok, Nick van Gastel, Michael F. Wells, Kevin S. Smith, Francesco Limone, Irena Kadiu, Jin-Yuan Wang, Pierce Eggan, James Keaney, Gaëlle Gillet, Christopher Cantrell, Aaron Burberry, Olli Pietilainen, Alexander Couto, Kevin Eggan
Publikováno v:
Nature
A hexanucleotide-repeat expansion in C9ORF72 is the most common genetic variant that contributes to amyotrophic lateral sclerosis and frontotemporal dementia1,2. The C9ORF72 mutation acts through gain- and loss-of-function mechanisms to induce pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae1adabc77cc3f1fb65c651a8e1df86
https://europepmc.org/articles/PMC7416879/
https://europepmc.org/articles/PMC7416879/
Autor:
Kirill Shkura, Seon-Ah Chong, Gaëlle Gillet, Pierre Gressens, James Keaney, Jacques Behmoaras, Andrée Delahaye-Duriez, Catherine Vandenplas, Isabelle Niespodziany, Bénédicte Danis, Patrik Foerch, Marvin Johnson, Liisi Laaniste, Karine Leclercq, Manuela Mazzuferi, Prashant K. Srivastava, Frederic Vanclef, Juliette Van Steenwinckel, Julien Gasser, Enrico Petretto, Irena Kadiu, Patrice Godard, Alvaro Cardenas, Jonathan van Eyll, Georges Mairet-Coello, Rafal M. Kaminski
Publikováno v:
Epilepsy Currents
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Srivastava, P K, van Eyll, J, Godard, P, Mazzuferi, M, Delahaye-Duriez, A, Steenwinckel, J V, Gressens, P, Danis, B, Vandenplas, C, Foerch, P, Leclercq, K, Mairet-Coello, G, Cardenas, A, Vanclef, F, Laaniste, L, Niespodziany, I, Keaney, J, Gasser, J, Gillet, G, Shkura, K, Chong, S-A, Behmoaras, J, Kadiu, I, Petretto, E, Kaminski, R M & Johnson, M R 2018, ' A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target ', Nature Communications, vol. 9, no. 1, pp. 3561 . https://doi.org/10.1038/s41467-018-06008-4
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Srivastava, P K, van Eyll, J, Godard, P, Mazzuferi, M, Delahaye-Duriez, A, Steenwinckel, J V, Gressens, P, Danis, B, Vandenplas, C, Foerch, P, Leclercq, K, Mairet-Coello, G, Cardenas, A, Vanclef, F, Laaniste, L, Niespodziany, I, Keaney, J, Gasser, J, Gillet, G, Shkura, K, Chong, S-A, Behmoaras, J, Kadiu, I, Petretto, E, Kaminski, R M & Johnson, M R 2018, ' A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target ', Nature Communications, vol. 9, no. 1, pp. 3561 . https://doi.org/10.1038/s41467-018-06008-4
Srivastava PK, van Eyll J, Godard P, Mazzuferi M, Delahaye-Duriez A, Steenwinckel JV, et al. A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target. Nat Commun. 2018;9(1):3561. doi:10.1038/s41467-018-06008-4.Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c628bab6c1290f55dc9c3b73de6332f5
https://pubmed.ncbi.nlm.nih.gov/31035818
https://pubmed.ncbi.nlm.nih.gov/31035818
Autor:
Julien Gasser, Gaelle Gillet, Jorge S. Valadas, Laura Rouvière, Apoorva Kotian, Wenqiang Fan, James Keaney, Irena Kadiu
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disease caused by CAG repeats in exon 1 of the HTT gene. A hallmark of HD along with other psychiatric and neurodegenerative diseases is alteration in the neuronal circu
Externí odkaz:
https://doaj.org/article/36f81fae85e74d06aa8c531767ce20bb
Autor:
Prashant K. Srivastava, Jonathan van Eyll, Patrice Godard, Manuela Mazzuferi, Andree Delahaye-Duriez, Juliette Van Steenwinckel, Pierre Gressens, Benedicte Danis, Catherine Vandenplas, Patrik Foerch, Karine Leclercq, Georges Mairet-Coello, Alvaro Cardenas, Frederic Vanclef, Liisi Laaniste, Isabelle Niespodziany, James Keaney, Julien Gasser, Gaelle Gillet, Kirill Shkura, Seon-Ah Chong, Jacques Behmoaras, Irena Kadiu, Enrico Petretto, Rafal M. Kaminski, Michael R. Johnson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify
Externí odkaz:
https://doaj.org/article/c0cffc3635504945bbe2f39f8175da2f