α-Glucosidase Inhibitory Activity of Tannat Grape Phenolic Extracts in Relation to Their Ripening Stages

Autor: Auriane Dudoit, Nawel Benbouguerra, Tristan Richard, Ruth Hornedo-Ortega, Josep Valls-Fonayet, Gaëlle Coussot, Cédric Saucier

Publikováno v: Biomolecules, Vol 10, Iss 8, p 1088 (2020)

The present study aimed to screen grape extracts as novel α-glucosidase inhibitors to prevent type-2 diabetes and hyperglycemia. The total polyphenol content (TPC) was measured by Folin-Ciocalteu assay and the stilbene, anthocyanin and flavan-3-ol c

Externí odkaz: https://doaj.org/article/baf2885dd855428aa77c2fcd3366cacd

A gold standard method for the evaluation of antibody-based materials functionality: Approach to forced degradation studies

Autor: Michel Dobrijevic, Gaëlle Coussot, Aurélie Le Postollec, Clément Faye

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2018, 152, pp.17-24. ⟨10.1016/j.jpba.2018.01.041⟩

The scope of this paper is to present a gold standard method to evaluate functional activity of antibody (Ab)-based materials during the different phases of their development, after their exposure to forced degradations or even during routine quality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ca9b95c6fb6dbdb5b28c6748e3cc2a
https://doi.org/10.1016/j.jpba.2018.01.041

Photochemistry on the Space Station—Antibody Resistance to Space Conditions after Exposure Outside the International Space Station

Autor: Bartos Przybyla, Michel Dobrijevic, Mickael Baqué, Didier Chaput, Gaëlle Coussot, Clément Faye, Thomas Berger, Flavie Vigier, O. Vandenabeele-Trambouze, Aurélie Le Postollec, Hervé Cottin, Sebastien Incerti

Publikováno v: Astrobiology
Astrobiology, Mary Ann Liebert, 2019, 19 (8), pp.1053-1062. ⟨10.1089/ast.2018.1907⟩
Astrobiology, 2019, 19 (8), pp.1053-1062. ⟨10.1089/ast.2018.1907⟩
Astrobiology (1531-1074) (Mary Ann Liebert, Inc), 2019-08, Vol. 19, N. 8, P. 1053-1062

International audience; Antibody-based analytical instruments are under development to detect signatures of life on planetary bodies.Antibodies are molecular recognition reagents able to detect their target at sub-nanomolar concentrations, withhigh a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb15535852697cc097344d6df8a42e5
https://hal.archives-ouvertes.fr/hal-02972216

Photochemistry on the Space Station—Aptamer Resistance to Space Conditions: Particles Exposure from Irradiation Facilities and Real Exposure Outside the International Space Station

Autor: Jerome Caron, Didier Chaput, Gaëlle Coussot, Bartos Przybyla, Corinne Ravelet, Clément Faye, Michel Dobrijevic, Thomas Berger, Sebastien Incerti, Emmanuelle Fiore, Flavie Vigier, O. Vandenabeele-Trambouze, Aurélie Le Postollec, Mickael Baqué, Hervé Cottin, Eric Peyrin

Publikováno v: Astrobiology
Astrobiology, 2019, 19 (8), pp.1063-1074. ⟨10.1089/ast.2018.1896⟩
Astrobiology, Mary Ann Liebert, 2019, 19 (8), pp.1063-1074. ⟨10.1089/ast.2018.1896⟩
Astrobiology (1531-1074) (Mary Ann Liebert, Inc), 2019-08, Vol. 19, N. 8, P. 1063-1074

International audience; Some microarray-based instruments that use bioaffinity receptors such as antibodies or aptamers are under development to detect signatures of past or present life on planetary bodies. Studying the resistance of such instrument

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f97b7f6689ddcddf5d5be31b22c5bbe
https://hal.archives-ouvertes.fr/hal-02272610

On-line capillary electrophoresis-based enzymatic methodology for the study of polymer-drug conjugates

Autor: Catherine Perrin, Gaëlle Coussot, Yoann Ladner, Caroline Bayart, Valérie Vigier, Clément Faye

Publikováno v: Journal of Chromatography A
Journal of Chromatography A, Elsevier, 2015, 1376, pp.159-166. ⟨10.1016/j.chroma.2014.12.029⟩

International audience; This work aims at studying the potentialities of an on-line capillary electrophoresis (CE)-based digestion methodology for evaluating polymer–drug conjugates degradability in the presence of free trypsin (in-solution digesti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4ddf32cd6a591228c0c53e7867ce50
https://doi.org/10.1016/j.chroma.2014.12.029