Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Gaëlle Angenard"'
Autor:
Matthis Desoteux, Betty Maillot, Kevin Bévant, Tanguy Ferlier, Raffaële Leroux, Gaëlle Angenard, Corentin Louis, Laurent Sulpice, Karim Boudjema, Cédric Coulouarn
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1278-1290 (2023)
Therapeutic targeting of the transforming growth factor beta (TGFβ) pathway in cancer represents a clinical challenge since TGFβ exhibits either tumor suppressive or tumor promoting properties, depending on the tumor stage. Thus, treatment with gal
Externí odkaz:
https://doaj.org/article/8f3cd7b53e6943a79ed9f68a73604fa1
Autor:
Luis Cano, Lise Desquilles, Gevorg Ghukasyan, Gaëlle Angenard, Clémence Landreau, Anne Corlu, Bruno Clément, Bruno Turlin, Eric Le Ferrec, Caroline Aninat, Julie Massart, Orlando Musso
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100936- (2024)
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) results in steatosis, inflammation (steatohepatitis), and fibrosis. Patients with MASLD more likely develop liver injury in coronavirus disease 2019 (COVID-19), cause
Externí odkaz:
https://doaj.org/article/aa2fb9496f7f435db71adaf6231878ab
Autor:
Corentin Louis, Tanguy Ferlier, Raffaële Leroux, Raphaël Pineau, Matthis Desoteux, Panagiotis Papoutsoglou, Delphine Leclerc, Gaëlle Angenard, Javier Vaquero, Rocio I.R. Macias, Julien Edeline, Cédric Coulouarn
Publikováno v:
JHEP Reports, Vol 5, Iss 12, Pp 100900- (2023)
Background & Aims: Intrahepatic cholangiocarcinoma (iCCA) is a deadly cancer worldwide with an increasing incidence and limited therapeutic options. Therefore, there is an urgent need to open the field to new concepts for identifying clinically relev
Externí odkaz:
https://doaj.org/article/d65272770452400784fb8235c71e509e
Autor:
Kevin Bévant, Matthis Desoteux, Gaëlle Angenard, Raphaël Pineau, Stefano Caruso, Corentin Louis, Panagiotis Papoutsoglou, Laurent Sulpice, David Gilot, Jessica Zucman‐Rossi, Cédric Coulouarn
Publikováno v:
Hepatology Communications, Vol 6, Iss 5, Pp 1157-1171 (2022)
Transforming growth factor beta (TGF‐β) plays a key role in tumor progression, notably as a potent inducer of epithelial–mesenchymal transition (EMT). However, all of the molecular effectors driving TGFβ‐induced EMT are not fully characterize
Externí odkaz:
https://doaj.org/article/88f8ea927575427898d86aa5d00ead50
Ingenuity Pathway Analysis (IPA) of up- and down-regulated genes from the core human HCC signature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0312a0ed66a2dbb72e9055d5551cc9
https://doi.org/10.1158/0008-5472.22412982
https://doi.org/10.1158/0008-5472.22412982
Description of the core human HCC signature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056b239bc3daede08d479bc2585af763
https://doi.org/10.1158/0008-5472.22412988.v1
https://doi.org/10.1158/0008-5472.22412988.v1
Connectivity map results of the core human HCC signature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b70a32cad2cccfb8f04e989f1761db
https://doi.org/10.1158/0008-5472.22412976
https://doi.org/10.1158/0008-5472.22412976
Integrative genomics helped characterize molecular heterogeneity in hepatocellular carcinoma (HCC), leading to targeted drug candidates for specific HCC subtypes. However, no consensus was achieved for genes and pathways commonly altered in HCC. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f629c14ceee7b77c4a425d7b20babb6c
https://doi.org/10.1158/0008-5472.c.6508575.v1
https://doi.org/10.1158/0008-5472.c.6508575.v1
Enrichment of up- and down-regulated genes of the core human HCC signature in specific chromosome locations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d220bdfed8584ef734e5108e152560
https://doi.org/10.1158/0008-5472.22412985.v1
https://doi.org/10.1158/0008-5472.22412985.v1
List of genes included in the core enrichment for each drug from the up- or down-regulated genes of the core human HCC signature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9b34cbc0663bf811204edfd5d12aad
https://doi.org/10.1158/0008-5472.22412973
https://doi.org/10.1158/0008-5472.22412973