Chemical Fueling Enables Molecular Complexification of Self‐Replicators**

Autor: Jim Ottelé, Ankush Sood, Elio Mattia, Andreas S. Hussain, Sijbren Otto, Omer Markovitch, Kai Liu, Shuo Yang, Gaël Schaeffer

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(20), 11344-11349. WILEY-V C H VERLAG GMBH

Unravelling how the complexity of living systems can (have) emerge(d) from simple chemical reactions is one of the grand challenges in contemporary science. Evolving systems of self‐replicating molecules may hold the key to this question. Here we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4dddf2fbd61ae87e412eeba259e3769
https://doi.org/10.1002/anie.202016196

Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids

Autor: Charalampos G. Pappas, Jim Ottelé, Gaël Schaeffer, Bin Liu, Priscilla F Pieters, Meniz Altay, Sijbren Otto, Ivana Marić, Christoph Jurissek, Marc C. A. Stuart

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 142(9), 4184-4192. AMER CHEMICAL SOC

The conditions that led to the formation of the first organisms and the ways that life originates from a lifeless chemical soup are poorly understood. The recent hypothesis of ''RNA-peptide coevolution'' suggests that the current close relationship b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e43f3a94d7e28f3a820317c0216631
https://doi.org/10.1021/jacs.9b10796

Structural and Spectroscopic Properties of Assemblies of Self-Replicating Peptide Macrocycles

Autor: Siewert J. Marrink, Anna S. Bondarenko, Mathieu Surin, Thomas L. C. Jansen, Gaël Schaeffer, Yigit Altay, Julien Idé, Sijbren Otto, David Beljonne, Pim W. J. M. Frederix

Publikováno v: ACS Nano
Acs Nano, 11(8), 7858-7868. AMER CHEMICAL SOC

Self-replication at the molecular level is often seen as essential to the early origins of life. Recently a mechanism of self-replication has been discovered in which replicator self-assembly drives the process. We have studied one of the examples of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a96685dd050f68899a95984d67a847
http://europepmc.org/articles/PMC5616102

Lattice interactions and aggregation in solution-can the two be related?

Autor: Gaël Schaeffer, Jack Harrowfield

Publikováno v: Tetrahedron Letters, 55(51), 7076-7081. PERGAMON-ELSEVIER SCIENCE LTD

Comparison is made of the crystal structures of two different solvates of a molecule containing both H-bond donor and acceptor sites, which is found either as a monomer or a hexamer. The solid state features are analysed with respect to the behaviour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149c1ab5b3fdc1d340adb9edae1a00ca
https://research.rug.nl/en/publications/e58e6d62-c6e2-484b-b602-b9a8b64accc4

Metal-ion-induced shape switching

Autor: Jack M. Harrowfield, Anna K. H. Hirsch, Gaël Schaeffer, Jean-Marie Lehn

Publikováno v: Polyhedron
Polyhedron, Elsevier, 2012, 41, pp.40-43. ⟨10.1016/j.poly.2012.04.013⟩
Polyhedron, 41(1), 40-43. PERGAMON-ELSEVIER SCIENCE LTD

The unsymmetrical hydrazonobis(acylhydrazone) ligand L exists in solution as a mixture of isomers but complexes to Hg(II) with a major conformational change, affording a mixture of parallel and antiparallel binuclear double helicates. On crystallisat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4af6d40b3ffa1608b173c22ff7ad5c
https://research.rug.nl/en/publications/e33e217b-128d-4abe-8333-fd1cf9aae39b