Výsledky vyhledávání - "Gaël A Millot"

Akademický článek

MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut

Autor: Martial Marbouty, Agnès Thierry, Gaël A Millot, Romain Koszul

Publikováno v: eLife, Vol 10 (2021)

Bacteriophages play important roles in regulating the intestinal human microbiota composition, dynamics, and homeostasis, and characterizing their bacterial hosts is needed to understand their impact. We applied a metagenomic Hi-C approach on 10 heal

Externí odkaz: https://doaj.org/article/3c27d124bddf440586e2f26c4bf32f7d

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Akademický článek

Functional Assessment of Genetic Variants with Outcomes Adapted to Clinical Decision-Making.

Autor: Pierre Thouvenot, Barbara Ben Yamin, Lou Fourrière, Aurianne Lescure, Thomas Boudier, Elaine Del Nery, Anne Chauchereau, David E Goldgar, Claude Houdayer, Dominique Stoppa-Lyonnet, Alain Nicolas, Gaël A Millot

Publikováno v: PLoS Genetics, Vol 12, Iss 6, p e1006096 (2016)

Understanding the medical effect of an ever-growing number of human variants detected is a long term challenge in genetic counseling. Functional assays, based on in vitro or in vivo evaluations of the variant effects, provide essential information, b

Externí odkaz: https://doaj.org/article/913da120f9354ab2ab0a9e3f68b5bae6

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Akademický článek

A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1.

Autor: Philippine Eloy, Catherine Dehainault, Meriem Sefta, Isabelle Aerts, François Doz, Nathalie Cassoux, Livia Lumbroso le Rouic, Dominique Stoppa-Lyonnet, François Radvanyi, Gaël A Millot, Marion Gauthier-Villars, Claude Houdayer

Publikováno v: PLoS Genetics, Vol 12, Iss 2, p e1005888 (2016)

Retinoblastoma (Rb), the most common pediatric intraocular neoplasm, results from inactivation of both alleles of the RB1 tumor suppressor gene. The second allele is most commonly lost, as demonstrated by loss of heterozygosity studies. RB1 germline

Externí odkaz: https://doaj.org/article/a6405348669947ee817f96d350d92a6d

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Chlamydia trachomatis development requires both host glycolysis and oxidative phosphorylation but has only minor effects on these pathways

Autor: Maimouna D. N’Gadjaga, Stéphanie Perrinet, Michael G. Connor, Giulia Bertolin, Gaël A. Millot, Agathe Subtil

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2022, 298 (9), pp.102338. ⟨10.1016/j.jbc.2022.102338⟩

International audience; The obligate intracellular bacteria Chlamydia trachomatis obtain all nutrients from the cytoplasm of their epithelial host cells and stimulate glucose uptake by these cells. They even hijack host ATP, exerting a strong metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438436ffb95302e6a4969b44c1812430
https://hal.science/hal-03757326/document

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High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Publikováno v: Nature Biotechnology
Nature Biotechnology, 2020, 38, pp.715-721. ⟨10.1038/s41587-020-0466-7⟩
Nature Biotechnology, Nature Publishing Group, 2020, pp.715-721. ⟨10.1038/s41587-020-0466-7⟩
Nature Biotechnology, 38

International audience; Mining the antibody repertoire of plasma cells and plasmablasts could enable the discovery of useful antibodies for therapeutic or research purposes1. We present a method for high-throughput, single-cell screening of IgG-secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbfb651784dad67e1736e002c8ce9cc
https://doi.org/10.1038/s41587-020-0466-7

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The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors

Autor: Bianca Balbino, Julien Stackowicz, Kari C. Nadeau, Pauline Herviou, Ophélie Godon, Sébastien Brûlé, Delphine Sterlin, Andrew J. Murphy, Vera Voronina, Bruno Iannascoli, Odile Richard-Le Goff, Gaël A. Millot, Macdonald Lynn, Laurent L. Reber, Harris Faith, Pierre Bruhns

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2019, ⟨10.1172/JCI129697⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2019, ⟨10.1172/JCI129697⟩
J Clin Invest

International audience; Omalizumab is an anti-IgE monoclonal antibody (mAb) approved for the treatment of severe asthma and chronic spontaneous urticaria. Use of Omalizumab is associated with reported side effects, ranging from local skin inflammatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c06554f4a34ad7e3a43c7c44772130
https://doi.org/10.1172/jci129697

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Author response: MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut

Autor: Romain Koszul, Martial Marbouty, Gaël A. Millot, Agnès Thierry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cac887fc9dd19ebf15b80398dc1d74eb
https://doi.org/10.7554/elife.60608.sa2

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Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation

Autor: Gaël A. Millot, Diana Eccles, Lisa Wiesmüller, Jean-Yves Masson, Fergus J. Couch, Arne Nedergaard Kousholt, Ralph Scully, Maaike P.G. Vreeswijk, Marjanka K. Schmidt, Peter Bouwman, Shyam K. Sharan, Alvaro N.A. Monteiro

Publikováno v: Journal of Medical Genetics
Journal of Medical Genetics, 2020, Online ahead of print, pp.106368. ⟨10.1136/jmedgenet-2019-106368⟩
Journal of Medical Genetics, BMJ Publishing Group, 2020, Online ahead of print, pp.106368. ⟨10.1136/jmedgenet-2019-106368⟩
J Med Genet
Journal of Medical Genetics, 57(8), 509-518. BMJ PUBLISHING GROUP

Since the identification and cloning of BRCA1 in 1994,1 and shortly thereafter of BRCA2 ,2 genetic tests of germline DNA to identify pathogenic variants in genes linked to hereditary breast and ovarian cancer (HBOC) have become mainstream.3 These tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109428178362bb4aec07b0475e2961e1
https://hdl.handle.net/1887/3184404

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Author Correction: High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Publikováno v: Nature biotechnology. 38(6)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43c31368ccefd80a36a5c0ef41102df
https://pubmed.ncbi.nlm.nih.gov/32231335

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Transcription-dependent regulation of replication dynamics modulates genome stability

Autor: Marion Blin, Caroline Brossas, Gaël A. Millot, Mélanie Schmidt, Viola Nähse, Marie-Noëlle Prioleau, Michelle Debatisse, Benoît Le Tallec

Publikováno v: Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
Nature Structural and Molecular Biology, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩

International audience; Common fragile sites (CFSs) are loci that are hypersensitive to replication stress and hotspots for chromosomal rearrangements in cancers. CFSs replicate late in S phase, are cell-type specific and nest in large genes. The rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43eeaf52d0908fdafd2f3542152ba98e
https://doi.org/10.1038/s41594-018-0170-1

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