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Akademický článek

Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

Autor: Arijit Bhattacharya, Philippe Leprohon, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Gaétan Roy, Hélène Gingras, Anais Mestdagh, Barbara Papadopoulou, Marc Ouellette

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Here, Bhattacharya et al. chemically mutagenize Leishmania and identify genes associated with resistance to miltefosine and paromomycin by next generation sequencing. The study shows that a protein kinase (CDPK1) can mediate resistance to paromomycin

Externí odkaz: https://doaj.org/article/31297421268e443fb05fa40f1379e120

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Akademický článek

Decreased glutamate transport in acivicin resistant Leishmania tarentolae.

Autor: Gaétan Roy, Arijit Bhattacharya, Philippe Leprohon, Marc Ouellette

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010046 (2021)

Studies of drug resistance in the protozoan parasites of the genus Leishmania have been helpful in revealing biochemical pathways as potential drug targets. The chlorinated glutamine analogue acivicin has shown good activity against Leishmania cells

Externí odkaz: https://doaj.org/article/128a0f2bbe6742f8863d7844f436ddbe

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Akademický článek

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms

Autor: Christopher Fernandez-Prada, Mansi Sharma, Marie Plourde, Eva Bresson, Gaétan Roy, Philippe Leprohon, Marc Ouellette

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 2, Pp 165-173 (2018)

Increasing drug resistance towards first line antimony-derived compounds has forced the introduction of novel therapies in leishmaniasis endemic areas including amphotericin B and miltefosine. However, their use is threatened by the emergence and spr

Externí odkaz: https://doaj.org/article/8204443edef846f78f47e249c1f59fc0

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Akademický článek

Proteomic analysis of metacyclogenesis in Leishmania infantum wild-type and PTR1 null mutant

Autor: Wilfried Moreira, Danielle Légaré, Gina Racine, Gaétan Roy, Marc Ouellette

Publikováno v: EuPA Open Proteomics, Vol 4, Iss C, Pp 171-183 (2014)

The parasite Leishmania exhibits a dimorphic life cycle with promastigotes found in the insect vector and amastigotes residing within mammalian macrophages. In the insect, promastigotes undergo metacyclogenesis with two main stages, the procyclic and

Externí odkaz: https://doaj.org/article/db40ce13a7c84c53bdd9498cc8d5d0fd

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Akademický článek

Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.

Autor: Christopher Fernandez-Prada, Isabel M Vincent, Marie-Christine Brotherton, Mathew Roberts, Gaétan Roy, Luis Rivas, Philippe Leprohon, Terry K Smith, Marc Ouellette

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005171 (2016)

Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short administration of miltefosine (MF) is a drug combination effective for treating visceral leishmania

Externí odkaz: https://doaj.org/article/8e118853d9804ec2b37f570048adf6e9

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Akademický článek

Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania.

Autor: Jean-Michel Ubeda, Frédéric Raymond, Angana Mukherjee, Marie Plourde, Hélène Gingras, Gaétan Roy, Andréanne Lapointe, Philippe Leprohon, Barbara Papadopoulou, Jacques Corbeil, Marc Ouellette

Publikováno v: PLoS Biology, Vol 12, Iss 5, p e1001868 (2014)

Gene amplification of specific loci has been described in all kingdoms of life. In the protozoan parasite Leishmania, the product of amplification is usually part of extrachromosomal circular or linear amplicons that are formed at the level of direct

Externí odkaz: https://doaj.org/article/a5042d92e19a405689df92d32d178972

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Akademický článek

Genetic polymorphisms and drug susceptibility in four isolates of Leishmania tropica obtained from Canadian soldiers returning from Afghanistan.

Autor: Marie Plourde, Adriano Coelho, Yoav Keynan, Oscar E Larios, Momar Ndao, Annie Ruest, Gaétan Roy, Ethan Rubinstein, Marc Ouellette

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 1, p e1463 (2012)

Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease characterized by the presence of one or more lesions on the skin that usually heal spontaneously after a few months. Most cases of CL worldwide occur in Southwest Asia, Africa and South

Externí odkaz: https://doaj.org/article/6b109a381e1740ffbd34c607f250127c

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MRPA-independent mechanisms of antimony resistance in Leishmania infantum

Autor: Victoria Wagner, Marc Ouellette, Christopher Fernandez-Prada, Noélie Douanne, Gaétan Roy, Philippe Leprohon

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss, Pp 28-37 (2020)
International Journal for Parasitology: Drugs and Drug Resistance

Control of both human and canine leishmaniasis is based on a very short list of chemotherapeutic agents, headed by antimonial derivatives (Sb). The utility of these molecules is severely threatened by high rates of drug resistance. The ABC transporte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5dc4220d182fc0c18efc7fae677f097
http://www.sciencedirect.com/science/article/pii/S2211320720300051

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Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

Autor: Sophia Bigot, Arijit Bhattacharya, Hélène Gingras, Prasad K. Padmanabhan, Barbara Papadopoulou, Angana Mukherjee, Anais Mestdagh, Marc Ouellette, Philippe Leprohon, Gaétan Roy

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Microbial Cell

Leishmania parasites are responsible for a range of clinical manifestations ranging from self-resolving cutaneous sores to life-threatening diseases. The management of leishmaniasis is complicated in part by the scarcity of treatment options but also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58924c74b5415529d3dca50b458907f3
http://link.springer.com/article/10.1038/s41467-019-13344-6

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High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms

Autor: Mansi Sharma, Gaétan Roy, Christopher Fernandez-Prada, Eva Bresson, Marc Ouellette, Philippe Leprohon, Marie Plourde

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 2, Pp 165-173 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbe970b4ccf2ed03c2bb1a3d556487f
http://europepmc.org/articles/PMC6039308

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