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Akademický článek

ATF4/TXNIP/REDD1/mTOR signaling mediates the antitumor activities of liver X receptor in pancreatic cancers

Autor: Zhikang Chen, Xiaobo Lai, Hui Ding, Aijun Zhang, Yufei Sun, Jianhua Ling, Paul J. Chiao, Zihua Chen, Xuefeng Xia

Publikováno v: Cancer Innovation, Vol 1, Iss 1, Pp 55-69 (2022)

Abstract Background Limited by difficulties in early detection and availabilities of effective treatments, pancreatic cancer is a highly malignant disease with poor prognosis. Nuclear receptors are a family of ligand‐dependent transcription factors

Externí odkaz: https://doaj.org/article/6333fd30f52643d4961f44b5cbdd2705

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Akademický článek

LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice

Autor: Chaitanya K. Gavini, Nadia Elshareif, Gregory Aubert, Anand V. Germanwala, Nigel A. Calcutt, Virginie Mansuy-Aubert

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)

Abstract Background Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration. Silencing macr

Externí odkaz: https://doaj.org/article/91929b57cb8741daa50a9e577295d26d

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Akademický článek

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Approved LXR agonists exert unspecific effects on pancreatic β-cell function

Autor: Peter Krippeit-Drews, Jonas Maczewsky, Julia Kaiser, Gisela Drews

Publikováno v: Endocrine

Novel agonists of the nuclear liver-X-receptor (LXR) are designed to treat metabolic disorders or cancer. The rationale to develop these new drugs is based on promising results with established LXR agonist like T0901317 and GW3965. LXRα and LXRβ ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987b87219eddd7dd026d8e927b4fd2ce
http://europepmc.org/articles/PMC7308254

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Akademický článek

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LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice

Autor: Chaitanya K. Gavini, Nadia Elshareif, Gregory Aubert, Anand V. Germanwala, Nigel A. Calcutt, Virginie Mansuy-Aubert

Publikováno v: Journal of neuroinflammation, vol 19, iss 1

Background Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration. Silencing macrophages b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5239bed1e6e85f6ba2067f1c5cb03a6e
https://pubmed.ncbi.nlm.nih.gov/35219337

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Akt/mTOR and AMPK signaling pathways are responsible for liver X receptor agonist GW3965-enhanced gefitinib sensitivity in non-small cell lung cancer cell lines

Autor: Qingbo Wang, Bo Shen, Xiaobing Qin, Siwen Liu, Jifeng Feng

Publikováno v: Translational Cancer Research

Background This study was to systemically analyze the mechanism of LXR ligand GW3965-induced sensitivity to EGFR-TKI in EGFR-TKI-resistant non-small cell lung cancer (NSCLC) cell lines. Methods Gefitinib-resistant PC9 cell line (EGFR exon 19 deletion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562e5df99739d80850cb54abf423e484
http://europepmc.org/articles/PMC8797756

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Evaluation of the therapeutic potential of synthetic and natural LXR agonists (GW3965 and Nectandra reticulata) in the 3xTg-AD murine model of Alzheimer's disease

Autor: Caicedo Díaz, Jennifer Alejandra

Publikováno v: Repositorio UN
Universidad Nacional de Colombia
instacron:Universidad Nacional de Colombia

ilustraciones, fotografías, gráficas, tablas La enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo caracterizado por deterioro cognitivo y la presencia de placas amiloides y ovillos neurofibrilares. Los agonistas sintéticos del recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7fa1b5e18366c8366a45c4856bc5eeda
https://repositorio.unal.edu.co/handle/unal/81590

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Akademický článek

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Liver X Receptor Expression and Pentraxin 3 Production in Chronic Rhinosinusitis and Sinonasal Mucosal Fibroblast Cells

Autor: Ping-Hung Shen, Yih-Jeng Tsai, Sheng-Dean Luo, Wen-Bin Wu

Publikováno v: Journal of Clinical Medicine
Volume 10
Issue 3
Journal of Clinical Medicine, Vol 10, Iss 452, p 452 (2021)

The long pentraxin 3 (PTX3) is a prototypic molecule for recognizing pathogens. Liver X receptors (LXRs), belonging to nuclear receptors (NRs) for cholesterol metabolism through heterodimerizing with other NRs, were recently reported to participate i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960f979da10940bb29cc83e175ba8e2f
https://pubmed.ncbi.nlm.nih.gov/33503887

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