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Akademický článek

Heterogeneity and plasticity of tissue-resident memory T cells in skin diseases and homeostasis: a review

Autor: Guomu Liu, Ziyue Wang, Shanshan Li

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Skin tissue-resident memory T (Trm) cells are produced by antigenic stimulation and remain in the skin for a long time without entering the peripheral circulation. In the healthy state Trm cells can play a patrolling and surveillance role, but in the

Externí odkaz: https://doaj.org/article/ef52d2fe08ea4c6b95ef3e6fdf3fa6a8

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Akademický článek

The Combination of MBP and BCG-Induced Dendritic Cell Maturation through TLR2/TLR4 Promotes Th1 Activation In Vitro and Vivo

Autor: LiNa Jiang, GuoMu Liu, WeiHua Ni, NanNan Zhang, Jing Jie, Fei Xie, GuiXiang Tai

Publikováno v: Mediators of Inflammation, Vol 2017 (2017)

To explore whether TLR2/TLR4 could be involved in the maturation of dendritic cells and polarization of CD4+ T cells induced by dendritic cells stimulated with MBP and BCG, in vitro and in vivo experiments using TLR2−/− or TLR4−/− mice were e

Externí odkaz: https://doaj.org/article/4235bb0940fe4904bb84352a030c33e2

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An 8-gene signature predicts the prognosis of cervical cancer following radiotherapy

Autor: Hongyan Yuan, Jiang Jie, Fei Xie, Guomu Liu, Weihua Ni, Na Du, Dan Dong, Liang Guo, Guixiang Tai, Nannan Zhang

Publikováno v: Molecular Medicine Reports

Gene expression and DNA methylation levels affect the outcomes of patients with cancer. The present study aimed to establish a multigene risk model for predicting the outcomes of patients with cervical cancer (CerC) treated with or without radiothera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0be31b4f3dfb40f0c2dffb89316dc6b
http://europepmc.org/articles/PMC6755236

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MF59 Promoted the Combination of CpG ODN1826 and MUC1-MBP Vaccine-Induced Antitumor Activity Involved in the Enhancement of DC Maturation by Prolonging the Local Retention Time of Antigen and Down-Regulating of IL-6/STAT3

Autor: Jing Jie, Guomu Liu, Jingyue Feng, Desheng Huo, Yixuan Wu, Hongyan Yuan, Guixiang Tai, Weihua Ni

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10887

Our previous study found that CpG oligodeoxynucleotides 1826 (CpG 1826), combined with mucin 1 (MUC1)-maltose-binding protein (MBP) (M-M), had certain antitumor activity. However, this combination is less than ideal for tumor suppression (tumors vary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462ff42765cdd56db9d9941fd7ce30df
https://doi.org/10.3390/ijms231810887

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The Effect of Different Immunization Cycles of a Recombinant Mucin1-Maltose-Binding Protein Vaccine on T Cell Responses to B16-MUC1 Melanoma in Mice

Autor: Mengyu Jiang, Jingjing Wang, Hongyue Zhou, Guixiang Tai, Yu Liu, Guomu Liu, Zenan Zhang

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 5810, p 5810 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 16

We explored the effect of a recombinant mucin1-maltose-binding protein vaccine, including immunization cycles of recombinant mucin1-maltose-binding protein (MUC1-MBP) and CpG 2006 on T cell responses to human MUC1-overexpressing mouse melanoma B16 ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e7d51b7956435111ed4e995feddfe6
https://www.mdpi.com/1422-0067/21/16/5810

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The combination of maltose-binding protein and BCG-induced Th1 activation is involved in TLR2/9-mediated upregulation of MyD88-TRAF6 and TLR4-mediated downregulation of TRIF-TRAF3

Autor: Xiaoyu Zhai, Guomu Liu, Nannan Zhang, Xiaoyu Yang, Guixiang Tai, Weihua Ni, Hongyue Zhou

Publikováno v: Cellular Immunology. 325:56-63

Our previous study demonstrated that maltose-binding protein (MBP) activated Th1 through the TLR2-mediated MyD88-dependent pathway and the TLR4-mediated TRIF-dependent pathway. The combination of MBP and BCG synergistically induced Th1 activation, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4527d84212a2afdfc342d905f6669da3
https://doi.org/10.1016/j.cellimm.2018.02.006

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Mucin1 promotes the migration and invasion of hepatocellular carcinoma cells via JNK-mediated phosphorylation of Smad2 at the C-terminal and linker regions

Autor: Fang Wang, Guixiang Tai, Qiongshu Li, Ruiping Zhai, Guomu Liu, Nannan Zhang, Yingying Guo, Hongyan Yuan, Tanxiu Chen, Fei Xie, Weihua Ni, Juan Wang

Publikováno v: Scopus-Elsevier
Oncotarget

Mucin1 (MUC1), as an oncogene, plays a key role in the progression and tumorigenesis of many human adenocarcinomas. In this study, wound-healing, transwell migration and matrigel invasion assays showed that MUC1 promotes human hepatocellular carcinom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307ff99e85d8087e88667f3dfab64ba4
https://doi.org/10.18632/oncotarget.4267

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Escherichia coli Maltose-Binding Protein Induces M1 Polarity of RAW264.7 Macrophage Cells via a TLR2- and TLR4-Dependent Manner

Autor: Fang Wang, Wan Wang, Weihua Ni, Guomu Liu, Hongyan Yuan, Guixiang Tai

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 9896-9909 (2015)
Volume 16
Issue 5
Pages 9896-9909

Maltose-binding protein (MBP) is a critical player of the maltose/maltodextrin transport system in Escherichia coli. Our previous studies have revealed that MBP nonspecifically induces T helper type 1 (Th1) cell activation and activates peritoneal ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f5624256492e575f2800b5a9e2199b
http://europepmc.org/articles/PMC4463623

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