Zobrazeno 1 - 10
of 73
pro vyhledávání: '"GUNTHER L. EICHHORN"'
Publikováno v:
Biochemistry. 36:14794-14798
Standard preparations of Escherichia coli RNA polymerase harbor a 70 kDa protein with NTPase (beta-gamma cleavage) activity that is not a recognized polymerase subunit. The NTPase activity of this component, before and after separation from the polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ea47c50829eb4215d094e963fe85b3
https://doi.org/10.1021/bi970191r
https://doi.org/10.1021/bi970191r
Autor:
Patricia Clark, Gunther L. Eichhorn
Publikováno v:
Journal of Inorganic Biochemistry. 59:765-772
When DNA is treated with Cu(II) and then heated, the melting temperature (Tm) of the DNA is dramatically decreased (8). The Cu(II) binds to the DNA in such a way as to destabilize the double helix and help to break the hydrogen bonds between the base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e247d0916ac44c070b9233af5299a405
https://doi.org/10.1016/0162-0134(94)00057-h
https://doi.org/10.1016/0162-0134(94)00057-h
Autor:
Peter P. Chuknyisky, Richard B. Beal, Christopher P. Janzen, Carl Garland, Gunther L. Eichhorn, Patricia L. Clark, James J. Butzow, Edward Tarien
Publikováno v:
Proceedings of the National Academy of Sciences. 91:7613-7617
Distances between the metal ions bound to the product terminus i site and the substrate i + 1 site of Escherichia coli RNA polymerase range from 5.0 to 5.6 A when the substrate is complementary to a template base and from 6.5 to 7.0 A for a noncomple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be20560311b91ad785cad75db1a1e018
https://doi.org/10.1073/pnas.91.16.7613
https://doi.org/10.1073/pnas.91.16.7613
Autor:
Gunther L. Eichhorn
Publikováno v:
Coordination Chemistry Reviews. 128:167-173
The structure of a metal complex may be determined by the structure of the ligand or by the electronic configuration of the metal. In the latter case, the metal can induce a conformational change in the ligand. Such a conformational change is a usual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3612a6e068af8fae88c4b5de7a9c432b
https://doi.org/10.1016/0010-8545(93)80028-4
https://doi.org/10.1016/0010-8545(93)80028-4
Autor:
Gunther L. Eichhorn
Publikováno v:
ChemInform. 25
The structure of a metal complex may be determined by the structure of the ligand or by the electronic configuration of the metal. In the latter case, the metal can induce a conformational change in the ligand. Such a conformational change is a usual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40b53b6b0ad761ce03391e46b182a3c8
https://doi.org/10.1002/chin.199402312
https://doi.org/10.1002/chin.199402312
Publikováno v:
Biochemistry. 30:6454-6464
Escherichia coli RNA polymerase (RNAP) exhibits a strong selectivity for the secondary structure of its template DNA, as shown by the influence both of the DNA conformation on the transcription cycle and of the enzyme on the DNA conformation itself.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73168f5e9f723359be9dcf711ff7d45b
https://doi.org/10.1021/bi00240a016
https://doi.org/10.1021/bi00240a016
Publikováno v:
Biochemistry. 29:5987-5994
The two substrates between which an internucleotide bond is formed in RNA synthesis occupy two subsites, i and i + 1, on the active site of Escherichia coli RNA polymerase, and each subsite is associated with a metal ion. These ions are therefore use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835d8a1411c29e851edf8a192c60c0af
https://doi.org/10.1021/bi00477a016
https://doi.org/10.1021/bi00477a016
Autor:
Gunther L. Eichhorn, Edward Tarien, Ramadas Nirmala, Patricia Clark, Carl Garland, Joseph M. Rifkind
Publikováno v:
Biochemistry. 38(11)
A frequently used schematic model of transcriptional elongation shows an RNA polymerase molecule moving along a linear DNA. This model is of course highly idealized and not compatible with promoter sequences [Gralla, J. D. (1991) Cell 66, 415-418; Sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2655864e0fbb4d4c0c6a2a4110a8528
https://pubmed.ncbi.nlm.nih.gov/10079088
https://pubmed.ncbi.nlm.nih.gov/10079088
Autor:
Gunther L. Eichhorn
Publikováno v:
Experimental gerontology. 28(4-5)
The controversial role of aluminum in Alzheimer's disease (AD) is reviewed. While current data would suggest the lack of a causative role, alterations in the brain and other organ systems caused by AD might increase the penetration of aluminum as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdf225b40ccb62819c127b735bc0ccf
https://pubmed.ncbi.nlm.nih.gov/8224045
https://pubmed.ncbi.nlm.nih.gov/8224045
Autor:
Edward Tarien, Abraham Levy, Gunther L. Eichhorn, Rajasekharan P. Pillai, Peter P. Chuknyisky, Richard B. Beal
Publikováno v:
Biochemistry. 29(25)
Since a major function of RNA polymerase must be to bring together substrates in the optimal configuration for internucleotide bond formation, studies have been undertaken to understand the geometrical relationship of the two substrates. A model has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6831723af375cf8705814fbb563a18
https://pubmed.ncbi.nlm.nih.gov/2166570
https://pubmed.ncbi.nlm.nih.gov/2166570