Computational and mechanistic studies on the effect of galactoxyloglucan: Imatinib nanoconjugate in imatinib resistant K562 cells

Autor: Alphy Rose James, BS Unnikrishnan, R Priya, Manu M Joseph, TK Manojkumar, K Raveendran Pillai, R Shiji, GU Preethi, P Kusumakumary, TT Sreelekha

Publikováno v: Tumor Biology, Vol 39 (2017)

Imatinib mesylate, a BCR/ABL fusion protein inhibitor, is the first-line treatment against chronic myelogenous leukemia. In spite of its advantageous viewpoints, imatinib still has genuine impediments like undesirable side effects and tumor resistanc

Externí odkaz: https://doaj.org/article/3c8714b91db54580ace99041f324e889

A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate.

Autor: Unnikrishnan BS; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Medical College P.O., Thiruvananthapuram, Kerala, 695011, India., Preethi GU; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Medical College P.O., Thiruvananthapuram, Kerala, 695011, India., Sreelekha TT; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Medical College P.O., Thiruvananthapuram, Kerala, 695011, India. ttsreelekha@gmail.com.

Publikováno v: Scientific reports [Sci Rep] 2021 Apr 22; Vol. 11 (1), pp. 8721. Date of Electronic Publication: 2021 Apr 22.

Self-assembled drug loaded glycosyl-protein metal nanoconstruct: Detailed synthetic procedure and therapeutic effect in solid tumor treatment.

Autor: Unnikrishnan BS; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, 695011, Kerala, India., Maya S; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, 695011, Kerala, India., Preethi GU; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, 695011, Kerala, India., Anusree KS; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, 695011, Kerala, India., Reshma PL; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, 695011, Kerala, India., Archana MG; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, 695011, Kerala, India., Kaustabh MK; Chemical Sciences & Technology Division (CSTD), Organic Chemistry Section, CSIR- National Institute for Interdisciplinary Science & Technology (CSIR-NIIST), Thiruvananthapuram, 695019, Kerala, India., Sreelekha TT; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, 695011, Kerala, India. Electronic address: sreelekhatt@rcctvm.gov.in.

Publikováno v: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2020 Sep; Vol. 193, pp. 111082. Date of Electronic Publication: 2020 Apr 29.

Semi-interpenetrating nanosilver doped polysaccharide hydrogel scaffolds for cutaneous wound healing.

Autor: Preethi GU; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India., Unnikrishnan BS; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India., Sreekutty J; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India., Archana MG; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India., Anupama MS; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India., Shiji R; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India., Raveendran Pillai K; Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India., Joseph MM; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India; Chemical Sciences & Technology Division (CSTD), Organic Chemistry Section, CSIR - National Institute for Interdisciplinary Science & Technology (CSIR-NIIST), Thiruvananthapuram, 695019 Kerala, India., Syama HP; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India., Sreelekha TT; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India. Electronic address: sreelekhatt@rcctvm.gov.in.

Publikováno v: International journal of biological macromolecules [Int J Biol Macromol] 2020 Jan 01; Vol. 142, pp. 712-723. Date of Electronic Publication: 2019 Oct 14.

Galactomannan endowed biogenic silver nanoparticles exposed enhanced cancer cytotoxicity with excellent biocompatibility.

Autor: Padinjarathil H; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram-695011, Kerala, India., Joseph MM; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram-695011, Kerala, India., Unnikrishnan BS; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram-695011, Kerala, India., Preethi GU; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram-695011, Kerala, India., Shiji R; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram-695011, Kerala, India., Archana MG; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram-695011, Kerala, India., Maya S; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram-695011, Kerala, India., Syama HP; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram-695011, Kerala, India., Sreelekha TT; Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram-695011, Kerala, India. Electronic address: sreelekhatt@rcctvm.gov.in.

Publikováno v: International journal of biological macromolecules [Int J Biol Macromol] 2018 Oct 15; Vol. 118 (Pt A), pp. 1174-1182. Date of Electronic Publication: 2018 Jul 03.