Zobrazeno 1 - 10
of 80
pro vyhledávání: '"GTT glucose tolerance test"'
Autor:
Zhengcai Ju, Lin-shan Jiang, Xunjiang Wang, Wendong Huang, Zhengtao Wang, Siming Sun, Eryun Zhang, Lili Ding, Tong Tian, Qiaoling Yang, Li Yang, Yangmeng Wang, Yingbo Yang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1541-1554 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Obesity and its associated complications are highly related to a current public health crisis around the world. A growing body of evidence has indicated that G-protein coupled bile acid (BA) receptor TGR5 (also known as Gpbar-1) is a potential drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f45516d038bca9fd9338d0a4c987b9
http://www.sciencedirect.com/science/article/pii/S2211383521001106
http://www.sciencedirect.com/science/article/pii/S2211383521001106
Autor:
Pingping Luo, Rui Zhang, Qian Yu, George L. Tipoe, Ming Zheng, Xiaoming Sun, Yingxia Liu, Jia Xiao, Wei Li, Hong Zhang
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 668-679 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 668-679 (2021)
Alcoholic liver disease (ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of S-allylmercaptocysteine (SAMC) from aged garlic on liver cell injury. A ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71348640a2921fa24860e2b42b33f51
http://europepmc.org/articles/PMC7982498
http://europepmc.org/articles/PMC7982498
Autor:
Stan F.J. van de Graaf, Reinout L.P. Roscam Abbing, Joanne M. Donkers, Michel van Weeghel, Johannes H.M. Levels, Ronald P.J. Oude Elferink, Anita Boelen, Alfred H. Schinkel
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 451-466 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 10(3), 451-466. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 10(3), 451-466. Elsevier Inc.
Background & Aims Bile acids are important metabolic signaling molecules. Bile acid receptor activation promotes body weight loss and improves glycemic control. The incretin hormone GLP-1 and thyroid hormone activation of T4 to T3 have been suggested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4c156a368ab5b8e88ab5658e7840fc
http://www.sciencedirect.com/science/article/pii/S2352345X20300539
http://www.sciencedirect.com/science/article/pii/S2352345X20300539
Autor:
Adeline Bertola, Yeni Ait-Ahmed, Jing Ma, Bin Gao, Yukun Guan, Dechun Feng, Tamara Vanhaecke, Robim Marcelino Rodrigues, Bryan Mackowiak, Yaojie Fu, Xiaolin Wang, Wonhyo Seo, Seonghwan Hwang, Seol Hee Park, Yong He
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 151-171 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 151-171 (2022)
Background & Aims Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease, characterized by steatosis and hallmark liver neutrophil infiltration. NASH also is associated with adipose tissue inflammation, but the role of adipos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b081b10329fc04385b5e0d0855f694
https://biblio.vub.ac.be/vubir/eselectindependent-inflammation-and-lipolysis-in-adipose-tissue-exacerbate-steatosistonash-progression-via-s100a89(8daeb805-6a0b-4ba8-b9f4-f7e041564b4f).html
https://biblio.vub.ac.be/vubir/eselectindependent-inflammation-and-lipolysis-in-adipose-tissue-exacerbate-steatosistonash-progression-via-s100a89(8daeb805-6a0b-4ba8-b9f4-f7e041564b4f).html
PI3Kγ promotes obesity-associated hepatocellular carcinoma by regulating metabolism and inflammation
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 6, Pp 100359-(2021)
JHEP Reports, Vol 3, Iss 6, Pp 100359-(2021)
Background & Aims Phosphatidylinositides-3 kinases (PI3Ks) are promising drug targets for cancer therapy, but blockage of PI3K-AKT signalling causes hyperglycaemia, hyperinsulinaemia, and liver damage in patients, and hepatocellular carcinoma (HCC) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4bc1a713cb3358ff32fff23b3414f5
https://pubmed.ncbi.nlm.nih.gov/34704005
https://pubmed.ncbi.nlm.nih.gov/34704005
Autor:
Steven J. Fliesler, Sriganesh Ramachandra Rao, Sithara Raju Ponny, Ned A. Porter, Shailendra B. Patel, Vincent Fong, Babu Nageswararao Kanuri, Keri A. Tallman
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100002-(2021)
Journal of Lipid Research
Journal of Lipid Research
Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the enzyme 3β-hydroxysterol-Δ7 reductase. SLOS patients present clinically with dysmorphology and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628669fe15a4d77e5ef7fd0fbdf15f34
http://www.sciencedirect.com/science/article/pii/S0022227520437046
http://www.sciencedirect.com/science/article/pii/S0022227520437046
Autor:
Michael M. Swarbrick, Sylvia J. Gasparini, Mark S. Cooper, Holger Henneicke, Jingbao Li, Lauryn L. Cavanagh, Hong Zhou, Colette Fong-Yee, Markus J. Seibel, Elisabeth Karsten, Sarah Kim, Daphne Foong, Ruby C.Y. Lin, Joanne Thai
Publikováno v:
Molecular Metabolism, Vol 42, Iss, Pp 101098-(2020)
Molecular Metabolism
Molecular Metabolism
Objective Aging and chronic glucocorticoid excess share a number of critical features, including the development of central obesity, insulin resistance and osteoporosis. Previous studies have shown that skeletal glucocorticoid signalling increases wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2601bf9b23b0ab2ba1c9168d567906
http://www.sciencedirect.com/science/article/pii/S2212877820301721
http://www.sciencedirect.com/science/article/pii/S2212877820301721
Publikováno v:
Current Opinion in Endocrine and Metabolic Research
FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors in regulating enteroendocrine, metabolic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927a31cd4f88a4cda1330d17432ffbff
https://pubmed.ncbi.nlm.nih.gov/32835130
https://pubmed.ncbi.nlm.nih.gov/32835130
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100031-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100031-(2021)
Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in the proximity of membrane-bound O-acyltransferase domain-containing 7 (MBOAT7). To elucidate the link between these variants and fatty liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5a14a108c211284d76c444098061be
https://pubmed.ncbi.nlm.nih.gov/32859645
https://pubmed.ncbi.nlm.nih.gov/32859645
Autor:
Hotaik Sung, Gi Soo Youn, Haripriya Gupta, Sang Jun Yoon, Hyeong Seob Kim, Na Young Lee, Ye Rin Choi, Min Jea Shin, Seul Ki Kim, Ki Tae Suk
Publikováno v:
Journal of Ginseng Research
Journal of Ginseng Research, Vol 45, Iss 3, Pp 380-389 (2021)
Journal of Ginseng Research, Vol 45, Iss 3, Pp 380-389 (2021)
Metabolic syndrome (MS) refers to a clustering of at least three of the following medical conditions: high blood pressure, abdominal obesity, hyperglycemia, low high-density lipoprotein level, and high serum triglycerides. MS is related to a wide ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f778bf10cc7cf9bf02d31332130257dd
https://pubmed.ncbi.nlm.nih.gov/34025131
https://pubmed.ncbi.nlm.nih.gov/34025131