Výsledky vyhledávání - "GTPase-Activating Proteins/genetics/*metabolism"

Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion

Autor: Philippe A. Halban, Dieter Rondas, Martinho Soto-Ribeiro, Bernhard Wehrle-Haller, Alejandra Tomas

Publikováno v: The Journal of biological chemistry
Journal of Biological Chemistry, Vol. 287, No 4 (2012) pp. 2423-36

Actin cytoskeleton remodeling is well known to be positively involved in glucose-stimulated pancreatic beta cell insulin secretion. We have observed glucose-stimulated focal adhesion remodeling at the beta cell surface and have shown this to be cruci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9fa1e8da4cac7dad1525b2144c3668

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Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells

Autor: Katharina Rickenbach, Pascale Ribaux, Alejandra Tomas, Philippe A. Halban, Géraldine Parnaud, Karim Bouzakri

Publikováno v: Diabetes, Vol. 57, No 5 (2008) pp. 1195-204

OBJECTIVE— Protein kinase B/Akt plays a central role in β-cells, but little is known regarding downstream Akt substrates in these cells. Recently, Rab GTPase-activating protein AS160, a substrate of Akt, was shown to be involved in insulin modulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd7a0291fea3871c45816d63aa3a8a7
https://doi.org/10.2337/db07-1469

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Rac signal adaptation controls neutrophil mobilization from the bone marrow

Autor: Giulia Germena, Christoph Scheiermann, Irene Franco, Andrea Antonio Gamba, Augusta Di Savino, Alessandra Ghigo, Remco T. A. Megens, Emilio Hirsch, Francesca Copperi, Markus Sperandio, Angela R.M. Kurz, Miriam Martini, Anna Sapienza, Alessia Perino, Elisa Ciraolo, Carlo Cosimo Campa, Annalisa Camporeale

Publikováno v: Science Signaling, Vol. 9, No 459 (2016) P. ra124
Science Signaling, 9(459):ra124. American Association for the Advancement of Science

Mobilization of neutrophils from the bone marrow determines neutrophil blood counts and thus is medically important. Balanced neutrophil mobilization from the bone marrow depends on the retention-promoting chemokine CXCL12 and its receptor CXCR4 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34578d9dc194677a1f9bb626e66ac41e
http://hdl.handle.net/11583/2670814

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A barley Engulfment and Motility domain containing protein modulates Rho GTPase activating protein HvMAGAP1 function in the barley powdery mildew interaction

Autor: Ralph Hückelhoven, Caroline Hoefle

Engulfment and Motility (ELMO) proteins are involved in the regulation of small GTPase activity in eukaryotic organisms, but little is known about ELMO proteins in plants. We isolated the barley ELMO Domain Containing Protein, HvELMOD{_}C, in a yeast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a231320e039bf1c953ba1d4611018d
https://mediatum.ub.tum.de/1379817

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