Zobrazeno 1 - 10
of 18
pro vyhledávání: '"GTPase, guanosine triphosphatase"'
Autor:
Iulia Oancea, Andy Wu, Michael A. McGuckin, Sumaira Z. Hasnain, Rabina Giri, John D. Hooper, Veronika Schreiber, Brett C McWhinney, Julie M. Davies, Jakob Begun, Yonghua Sheng, David P. Fairlie, Saleh Y. Alabbas, Gregor Kijanka, Yaowu He, Ramya Movva, Andrew J. Lucke, Timothy H. Florin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f601ccce23a182b6171ce5a7c5598ec
http://www.sciencedirect.com/science/article/pii/S2352345X20300886
http://www.sciencedirect.com/science/article/pii/S2352345X20300886
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 491-506 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in colorectal cancer (CRC) development, although they are implicated in the modulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7a306ac692719a8347e0c547725351
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
Autor:
Naoki Minami, Hisanori Horiuchi, Kohei Wagatsuma, Daisuke Hirayama, Ryutaro Shirakawa, Tomoya Iida, Seiichi Hirota, Hiroki Ikeuchi, Minoru Matsuura, Hiroshi Nakase, Kentaro Kawakami, Masanori Nojima, Kanna Nagaishi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 277-293 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Ral guanosine triphosphatase–activating protein α2 (RalGAPα2) is the major catalytic subunit of the negative regulators of the small guanosine triphosphatase Ral, a member of the Ras subfamily. Ral regulates tumorigenesis and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d16d8f812582cc3f7b9947159562783
http://www.sciencedirect.com/science/article/pii/S2352345X19301390
http://www.sciencedirect.com/science/article/pii/S2352345X19301390
Autor:
Christoph Wittich, Claus A. M. Seidel, Radovan Dvorsky, Soheila Rezaei Adariani, Farhad Bazgir, Ehsan Amin, Mohammad Reza Ahmadian, Neda S. Kazemein Jasemi
Publikováno v:
The Journal of Biological Chemistry
RAS effectors specifically interact with GTP-bound RAS proteins to link extracellular signals to downstream signaling pathways. These interactions rely on two types of domains, called RAS-binding (RB) and RAS association (RA) domains, which share com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c908bf66f01ab88e26b2531338812873
http://europepmc.org/articles/PMC8163975
http://europepmc.org/articles/PMC8163975
Autor:
Keith Munson, Toshimasa Takahashi, Anna S. Gukovskaya, Iskandar Yakubov, Carli J. Wightman, Ilya Gukovsky, Olga A. Mareninova, Dustin L. Dillon, David W. Dawson, Herbert Y. Gaisano, Masaki Ohmuraya
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 599-622 (2022)
Cellular and molecular gastroenterology and hepatology, vol 13, iss 2
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 599-622 (2022)
Cellular and molecular gastroenterology and hepatology, vol 13, iss 2
Background Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cf84e7660abe7bc4aa24bb6ab842cf
https://pubmed.ncbi.nlm.nih.gov/34610499
https://pubmed.ncbi.nlm.nih.gov/34610499
Autor:
Brandon K. Fornwalt, Erhe Gao, Bryana R. Levitan, Christopher M. Haggerty, Jonathan Satin, Prabhakara R Nagareddy, Janet R. Manning, Catherine N. Withers, Ahmed Abdel-Latif, Lakshman Chelvarajan, Himi Tripathi, Douglas A. Andres
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 1, Pp 83-96 (2018)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • Rad-GTPase is an LTCC component that functions to govern calcium current in the myocardium. • Deletion of Rad increases myocardial contractility secondary to increased trigger calcium entry. • AMI induces heart
Highlights • Rad-GTPase is an LTCC component that functions to govern calcium current in the myocardium. • Deletion of Rad increases myocardial contractility secondary to increased trigger calcium entry. • AMI induces heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afb07219af2b9f2bb17a928ba4255c1
http://www.sciencedirect.com/science/article/pii/S2452302X17302267
http://www.sciencedirect.com/science/article/pii/S2452302X17302267
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 2, Pp 145-156 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 2, Pp 145-156 (2018)
Background & Aims During late embryonic development and through weaning, enterocytes of the ileum are highly endocytic. Defects in endocytosis and trafficking are implicated in neonatal disease, however, the mechanisms regulating trafficking during t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5b3c1c46f2e8e4b2e47d0be04e35b0
https://doi.org/10.1016/j.jcmgh.2017.11.001
https://doi.org/10.1016/j.jcmgh.2017.11.001
Autor:
Stephen J. Meltzer, Xi Liu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Gastric cancer (GC) remains the third most common cause of cancer death worldwide, with limited therapeutic strategies available. With the advent of next-generation sequencing and new preclinical model technologies, our understanding of its pathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950b09a9649220690e021736986bdf1f
https://doi.org/10.1016/j.jcmgh.2017.02.003
https://doi.org/10.1016/j.jcmgh.2017.02.003
Autor:
Kim E. Barrett
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Adherent-invasive Escherichia coli are implicated in inflammatory bowel disease, and mitochondrial dysfunction has been observed in biopsy specimens from patients with inflammatory bowel disease. As a novel aspect of adherent-invasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93a2d7cc23500777e0bf52617aa3632
http://europepmc.org/articles/PMC7846483
http://europepmc.org/articles/PMC7846483
Autor:
Lee A. Denson
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 426-427 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Mitochondria exist in a constantly remodelling network, and excessive fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric inflammation, but any contribution of altered mitochondrial dynamics (ie,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfbc0a62ca07f7cce53f7ceaf2eb4e9
http://www.sciencedirect.com/science/article/pii/S2352345X20300849
http://www.sciencedirect.com/science/article/pii/S2352345X20300849