Zobrazeno 1 - 10
of 74
pro vyhledávání: '"GTP-Binding Proteins/metabolism"'
Publikováno v:
Cell reports, vol. 41, no. 7, pp. 111636
The PYRIN inflammasome pathway is part of the innate immune response against invading pathogens. Unprovoked continuous activation of the PYRIN inflammasome drives autoinflammation and underlies several autoinflammatory diseases, including familial Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230f489fc5fef2d34887b0664d7b34b0
https://serval.unil.ch/resource/serval:BIB_8264D9307A8A.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_8264D9307A8A.P001/REF.pdf
Autor:
David Salom, Arum Wu, Christopher L. Sander, Els Pardon, Jan Steyaert, Philip D. Kiser, Krzysztof Palczewski
Publikováno v:
The FASEB Journal. 36
Binding of an extracellular signaling molecule to a G protein-coupled receptor (GPCR) results in G protein activation, which in turn triggers the production of second messengers. Although many advances have been achieved in understanding GPCR activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9991e6be88142c77208dd91f7c9d43d
https://doi.org/10.1096/fasebj.2022.36.s1.r2572
https://doi.org/10.1096/fasebj.2022.36.s1.r2572
Autor:
Anila Vadakumchery, Hemin Faraidun, Omar El Ayoubi, Issame Outaleb, Vera Schmid, Hend Abdelrasoul, Timm Amendt, Ahmad Khadour, Corinna Setz, Katharina Göhring, Karoline Lodd, Christoffer Hitzing, Alabbas Alkhatib, Mayas Bilal, Julian Benckendorff, Abdul Kader Al Shugri, Cord Herbert Brakebusch, Niklas Engels, Moumita Datta, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Publikováno v:
Vadakumchery, A, Faraidun, H, Ayoubi, O E, Outaleb, I, Schmid, V, Abdelrasoul, H, Amendt, T, Khadour, A, Setz, C, Göhring, K, Lodd, K, Hitzing, C, Alkhatib, A, Bilal, M, Benckendorff, J, Al Shugri, A K, Brakebusch, C H, Engels, N, Datta, M, Hobeika, E, Alsadeq, A & Jumaa, H 2022, ' The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells ', Frontiers in Immunology, vol. 13, 842340 . https://doi.org/10.3389/fimmu.2022.842340
The generation, differentiation, survival and activation of B cells are coordinated by signals emerging from the B cell antigen receptor (BCR) or its precursor, the pre-BCR. The adaptor protein SLP65 (also known as BLNK) is an important signaling fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4cb8226dad309d9aaf86d5a129e99f
Autor:
Verweij, Frederik, Bebelman, Maarten P, George, Anna, Couty, Mickael, Bécot, Anaïs, Palmulli, Roberta, Heiligenstein, Xavier, Sires-Campos, Julia, Raposo, Graca, Pegtel, Dirk Michiel, Van Niel, Guillaume, Sub Cell Biology, Celbiologie
Publikováno v:
The Journal of cell biology, 221(12):e202112032, 1-18. Rockefeller University Press
Verweij, F J, Bebelman, M P, George, A E, Couty, M, Bécot, A, Palmulli, R, Heiligenstein, X, Sirés-Campos, J, Raposo, G, Pegtel, D M & van Niel, G 2022, ' ER membrane contact sites support endosomal small GTPase conversion for exosome secretion ', Journal of Cell Biology, vol. 221, no. 12, e202112032 . https://doi.org/10.1083/jcb.202112032
Verweij, F J, Bebelman, M P, George, A E, Couty, M, Bécot, A, Palmulli, R, Heiligenstein, X, Sirés-Campos, J, Raposo, G, Pegtel, D M & van Niel, G 2022, ' ER membrane contact sites support endosomal small GTPase conversion for exosome secretion ', The Journal of cell biology, vol. 221, no. 12, e202112032, pp. 1-18 . https://doi.org/10.1083/jcb.202112032
Journal of Cell Biology, 221(12):e202112032. Rockefeller University Press
Journal of Cell Biology, 221(12), 1. Rockefeller University Press
Verweij, F J, Bebelman, M P, George, A E, Couty, M, Bécot, A, Palmulli, R, Heiligenstein, X, Sirés-Campos, J, Raposo, G, Pegtel, D M & van Niel, G 2022, ' ER membrane contact sites support endosomal small GTPase conversion for exosome secretion ', Journal of Cell Biology, vol. 221, no. 12, e202112032 . https://doi.org/10.1083/jcb.202112032
Verweij, F J, Bebelman, M P, George, A E, Couty, M, Bécot, A, Palmulli, R, Heiligenstein, X, Sirés-Campos, J, Raposo, G, Pegtel, D M & van Niel, G 2022, ' ER membrane contact sites support endosomal small GTPase conversion for exosome secretion ', The Journal of cell biology, vol. 221, no. 12, e202112032, pp. 1-18 . https://doi.org/10.1083/jcb.202112032
Journal of Cell Biology, 221(12):e202112032. Rockefeller University Press
Journal of Cell Biology, 221(12), 1. Rockefeller University Press
Exosomes are endosome-derived extracellular vesicles involved in intercellular communication. They are generated as intraluminal vesicles within endosomal compartments that fuse with the plasma membrane (PM). The molecular events that generate secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46e5d5a4c72e6d8647731eb57dd3dee
https://hdl.handle.net/1874/424418
https://hdl.handle.net/1874/424418
Autor:
Guy Serre, Marie Reynier, Alain Moga, Corinne Leprince, Sophie Allart, Dominique Goudounèche, Michel Simon
Publikováno v:
Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
International audience; Myosin Vb (Myo5b) is an unconventional myosin involved in the actin-dependent transport and tethering of intracellular organelles. In the epidermis, granular keratinocytes accumulate cytoplasmic lamellar bodies (LBs), secretor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b23279e57f8e5cb9731c489548ae9e
https://doi.org/10.1016/j.jid.2018.12.021
https://doi.org/10.1016/j.jid.2018.12.021
Autor:
Arthur D. Conigrave, Thor C. Møller, Hans Bräuner-Osborne, Andrew N. Keller, Daniela Riccardi, Katie Leach, Donald T. Ward, Enikö Kállay, Fadil M. Hannan, Rebecca S. Mason, Tracy M. Josephs, Rajesh V. Thakker
Publikováno v:
Leach, K, Hannan, F M, Josephs, T M, Keller, A N, Møller, T C, Ward, D T, Kallay, E, Mason, R S, Thakker, R V, Riccardi, D, Conigrave, A D & Bräuner-Osborne, H 2020, ' International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function ', Pharmacological Reviews, vol. 72, no. 3, pp. 558-604 . https://doi.org/10.1124/pr.119.018531
Pharmacological Reviews
Pharmacol Rev
Pharmacological Reviews
Pharmacol Rev
The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, γ-glutamyl peptides, polyamines, polycation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172ef793c4bcbce0c405d4a538a416f0
https://ora.ox.ac.uk/objects/uuid:36ba0adf-bb2b-4474-a8fa-928bf788b385
https://ora.ox.ac.uk/objects/uuid:36ba0adf-bb2b-4474-a8fa-928bf788b385
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Familial amyloid polyneuropathy (FAP) is a neurodegenerative disorder whose major hallmark is the deposition of mutated transthyretin (TTR) in the form of amyloid fibrils in the peripheral nervous system (PNS). The exposure of PNS axons to extracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7293eb0f1ea9079f11b5b96951a1470e
https://doi.org/10.1038/s41598-020-70377-4
https://doi.org/10.1038/s41598-020-70377-4
Publikováno v:
Neuroscience Letters
Neuroscience Letters, Elsevier, 2021, 749, ⟨10.1016/j.neulet.2021.135724⟩
Neuroscience Letters, 2021, 749, pp.135724. ⟨10.1016/j.neulet.2021.135724⟩
Neuroscience Letters, Elsevier, 2021, 749, ⟨10.1016/j.neulet.2021.135724⟩
Neuroscience Letters, 2021, 749, pp.135724. ⟨10.1016/j.neulet.2021.135724⟩
International audience; Interplay between physiological systems in the body plays a prominent role in health and disease. At the cellular level, such interplay is orchestrated through the binding of specific ligands to their receptors expressed on ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09f9fdf9bdba772b56011ab80dcc466
https://doi.org/10.1016/j.neulet.2021.135724
https://doi.org/10.1016/j.neulet.2021.135724
Autor:
Alexey Koval, Chen Lin, Anne-marie Lüchtenborg, Vladimir L. Katanaev, Oleksii Bilousov, Gonzalo P. Solis
Publikováno v:
Cell, Vol. 170, No 5 (2017) pp. 939-955.e24
Cell, vol. 170, no. 5, pp. 939-955.e24
Cell, vol. 170, no. 5, pp. 939-955.e24
To form protrusions like neurites, cells must coordinate their induction and growth. The first requires cytoskeletal rearrangements at the plasma membrane (PM), the second requires directed material delivery from cell's insides. We find that the Gαo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20cacad29e4dc2a9f9594349cef9572
https://archive-ouverte.unige.ch/unige:112473
https://archive-ouverte.unige.ch/unige:112473
Publikováno v:
Biochemical Journal, Vol. 473, No 4 (2016) pp. 371-381
Biochemical Journal, vol. 473, no. 4, pp. 371-381
Biochemical Journal, vol. 473, no. 4, pp. 371-381
Overactivation of the Wnt signalling pathway underlies oncogenic transformation and proliferation in many cancers, including the triple-negative breast cancer (TNBC), the deadliest form of tumour in the breast, taking about a quarter of a million liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556fa3a1cb211ccb686be902f2ffa064
https://doi.org/10.1042/bj20150913
https://doi.org/10.1042/bj20150913