Zobrazeno 1 - 10
of 44
pro vyhledávání: '"GTP, Guanosine triphosphate"'
Autor:
Alice M. Banks, Colette J. Whitfield, Steven R. Brown, David A. Fulton, Sarah A. Goodchild, Christopher Grant, John Love, Dennis W. Lendrem, Jonathan E. Fieldsend, Thomas P. Howard
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 218-229 (2022)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • Novel cell-free protein synthesis reaction buffer improves performance by 400%. • Enhanced performance is maintained across the synthesis of different proteins. • Protein synthesis performance is robust acro
Highlights • Novel cell-free protein synthesis reaction buffer improves performance by 400%. • Enhanced performance is maintained across the synthesis of different proteins. • Protein synthesis performance is robust acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d8a1b131f6dc02f2654a6fd7aef7a7
http://www.sciencedirect.com/science/article/pii/S2001037021005213
http://www.sciencedirect.com/science/article/pii/S2001037021005213
Autor:
Qilong Wang, Yanze Yang, Mei Du, Jinna Wei, Xianxian Zheng, Zhang Han, Erwei Liu, Xiumei Gao, Yuefei Wang, Patrick Kwabena Oduro
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 50-75 (2022)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf60046ceb32698b7a7ea7c3674b44
http://www.sciencedirect.com/science/article/pii/S2211383521001775
http://www.sciencedirect.com/science/article/pii/S2211383521001775
Autor:
Kasper Hoebe, Shrinivas Bishu, John Y. Kao, Varsha Ganesan, Ankit Sharma, Yanfen Yang, Chang Zeng, Rodney D. Newberry, Sahiti Marella, Simon P. Hogan, Philip D. King, Ariel Munitz, Jazib Uddin, Taeko K. Noah, Lee A. Denson, Andrew R. Patterson, Simone Vanoni, Lisa Waggoner, Senad Divanovic, Paul S. Foster, Michael J. Rosen, S. M. S. Tomar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Background & Aims CD4+ T cells are regulated by activating and inhibitory cues, and dysregulation of these proper regulatory inputs predisposes these cells to aberrant inflammation and exacerbation of disease. We investigated the role of the inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bc9234d68120dd2171e099da6a99f4
http://europepmc.org/articles/PMC8531983
http://europepmc.org/articles/PMC8531983
Autor:
Iulia Oancea, Andy Wu, Michael A. McGuckin, Sumaira Z. Hasnain, Rabina Giri, John D. Hooper, Veronika Schreiber, Brett C McWhinney, Julie M. Davies, Jakob Begun, Yonghua Sheng, David P. Fairlie, Saleh Y. Alabbas, Gregor Kijanka, Yaowu He, Ramya Movva, Andrew J. Lucke, Timothy H. Florin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f601ccce23a182b6171ce5a7c5598ec
http://www.sciencedirect.com/science/article/pii/S2352345X20300886
http://www.sciencedirect.com/science/article/pii/S2352345X20300886
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by motivating the adaptive anti-tumor immunity. Particularly, the checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c604607610f05b2d37da5b2cce00382
http://www.sciencedirect.com/science/article/pii/S2211383519316946
http://www.sciencedirect.com/science/article/pii/S2211383519316946
Autor:
Hossam M. Abdallah, Gamal A. Mohamed, Ali M. El-Halawany, Martin K. Safo, Noura A. Hassan, Hany M. El-Bassossy
Publikováno v:
Journal of Advanced Research, Vol 24, Iss, Pp 273-279 (2020)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Highlights • Methanol extract of Psiadia punctulata (MAPP) produced a significant vasodilation. • Chloroform fraction and its methylated flavonoids were responsible for this effect. • Vasodilation is referred to endothel
Highlights • Methanol extract of Psiadia punctulata (MAPP) produced a significant vasodilation. • Chloroform fraction and its methylated flavonoids were responsible for this effect. • Vasodilation is referred to endothel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e154d40b7f6c70738bd46a118a460f
http://www.sciencedirect.com/science/article/pii/S2090123220300023
http://www.sciencedirect.com/science/article/pii/S2090123220300023
Autor:
Christoph Wittich, Claus A. M. Seidel, Radovan Dvorsky, Soheila Rezaei Adariani, Farhad Bazgir, Ehsan Amin, Mohammad Reza Ahmadian, Neda S. Kazemein Jasemi
Publikováno v:
The Journal of Biological Chemistry
RAS effectors specifically interact with GTP-bound RAS proteins to link extracellular signals to downstream signaling pathways. These interactions rely on two types of domains, called RAS-binding (RB) and RAS association (RA) domains, which share com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c908bf66f01ab88e26b2531338812873
http://europepmc.org/articles/PMC8163975
http://europepmc.org/articles/PMC8163975
Publikováno v:
The Journal of Biological Chemistry
The human dedicator of cytokinesis (DOCK) family consists of 11 structurally conserved proteins that serve as atypical RHO guanine nucleotide exchange factors (RHO GEFs). These regulatory proteins act as mediators in numerous cellular cascades that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a6616905efc2a2ef77da8d684aca0b
http://europepmc.org/articles/PMC8063744
http://europepmc.org/articles/PMC8063744
Autor:
Tessa R. Young, Evelyne Deery, Anastasia Cooke, Martin J. Warren, Deenah Osman, Nigel J. Robinson
Publikováno v:
Biochimica et Biophysica Acta. Molecular Cell Research
Vitamin B12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that represents one of the most complex small molecules made by nature. In prokaryotes it is utilised as a cofactor, coenzyme, light sensor and gene regulator yet ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ace2dec5de2d9cde658800a4c92af8b
http://europepmc.org/articles/PMC7689651
http://europepmc.org/articles/PMC7689651
Autor:
Skyler Kuhn, Michael M Gottesman, Frances Maher, Da Yin, Robert W. Robey, Jordan M. Hotz, Sachi Horibata, Ruchi P. Patel
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 1, Pp 100917-(2021)
Translational Oncology, Vol 14, Iss 1, Pp 100917-(2021)
Highlights • Subpopulations of cisplatin-resistant cells are cross-resistant to anti-microtubule drugs. • Resistance mechanisms in cisplatin-resistant ovarian cancer cells are diverse. • Increased TNF and NFκB signaling found in cisplatin-resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636ba93dc8cc9508c9c866f6ce289f2c
http://europepmc.org/articles/PMC7586247
http://europepmc.org/articles/PMC7586247