Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

Autor: Rahil Taujale, Aarya Venkat, Liang-Chin Huang, Zhongliang Zhou, Wayland Yeung, Khaled M Rasheed, Sheng Li, Arthur S Edison, Kelley W Moremen, Natarajan Kannan

Publikováno v: eLife, Vol 9 (2020)

Glycosyltransferases (GTs) are prevalent across the tree of life and regulate nearly all aspects of cellular functions. The evolutionary basis for their complex and diverse modes of catalytic functions remain enigmatic. Here, based on deep mining of

Externí odkaz: https://doaj.org/article/3af3aed9f09e483db012d4bc7e1b0006

Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases.

Autor: Taujale R; Institute of Bioinformatics, University of Georgia, Athens, Georgia.; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia., Venkat A; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia., Huang LC; Institute of Bioinformatics, University of Georgia, Athens, Georgia., Zhou Z; Department of Computer Science, University of Georgia, Athens, Georgia., Yeung W; Institute of Bioinformatics, University of Georgia, Athens, Georgia., Rasheed KM; Department of Computer Science, University of Georgia, Athens, Georgia., Li S; Department of Computer Science, University of Georgia, Athens, Georgia., Edison AS; Institute of Bioinformatics, University of Georgia, Athens, Georgia.; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia., Moremen KW; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia., Kannan N; Institute of Bioinformatics, University of Georgia, Athens, Georgia.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia.

Publikováno v: ELife [Elife] 2020 Apr 01; Vol. 9. Date of Electronic Publication: 2020 Apr 01.