Výsledky vyhledávání - "GSSG, Glutathione disulfide"

Thiol antioxidants protect human lens epithelial (HLE B-3) cells against

Autor: Annalise, Pfaff, Anna, Chernatynskaya, Hannah, Vineyard, Nuran, Ercal

Publikováno v: Biochemistry and Biophysics Reports

Oxidative damage to lens epithelial cells plays an important role in the development of age-related cataract, and the health of the lens has important implications for overall ocular health. As a result, there is a need for effective therapeutic agen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6ad6a048992849fbae63780b9c9e9c3
https://pubmed.ncbi.nlm.nih.gov/35128081

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Deciphering rice metabolic flux reprograming under salinity stress via in silico metabolic modeling

Autor: Supachitra Chadchawan, Kwanjeera Wanichthanarak, Chuthamas Boonchai, Wichian Sangwongchai, Thammaporn Kojonna, Maysaya Thitisaksakul

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3555-3566 (2020)
Computational and Structural Biotechnology Journal

Highlights • Integrative GEMs can reveal the metabolic responses of rice to salinity stress. • Photosynthesis and hexose utilization were downregulated by salinity stress. • Photorespiration was enhanced and could contribute to redox homeostasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c729cb2070115e67cb7a81c79e1941e
http://www.sciencedirect.com/science/article/pii/S2001037020304906

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Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

Autor: Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30b76b24a28a9236a78a6ec2b0a30
https://pubmed.ncbi.nlm.nih.gov/35024303

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Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils

Autor: Mark B. Hampton, Jürgen Bernhagen, Lisa Schindler, Nina Dickerhof, Leon Smyth

Publikováno v: Redox Biology
Redox Biology, Vol 41, Iss, Pp 101946-(2021)

Background Macrophage migration inhibitory factor (MIF) is an important immuno-regulatory cytokine and is elevated in inflammatory conditions. Neutrophils are the first immune cells to migrate to sites of infection and inflammation, where they genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea58a0bcf6db131c0df3a8cdd80fdd4
https://pubmed.ncbi.nlm.nih.gov/33823474

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Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes

Autor: Dagmar Schumacher, Yoko Oguchi, Peter P. Nawroth, Jakob Morgenstern, Nadine Volk, Marc Freichel, Jan B. Groener, Stefan Kopf, Thomas Fleming

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 18, Iss, Pp 143-152 (2018)
Mol. Metab. 18, 143-152 (2018)

Objectives: The deficit of Glyoxalase I (Glo1) and the subsequent increase in methylglyoxal (MG) has been reported to be one the five mechanisms by which hyperglycemia causes diabetic late complications. Aldo-keto reductases (AKR) have been shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3236e0c9d5fd2526131b64d934508de2
https://doi.org/10.1016/j.molmet.2018.09.005

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Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line

Autor: Dean G. Assimos, Vidhush K. Yarlagadda, Tanecia Mitchell, Vikram Saini, Oreoluwa O. Adedoyin, Ross P. Holmes, Mikita Patel

Publikováno v: Redox Biology, Vol 15, Iss C, Pp 207-215 (2018)
Redox Biology

Monocytes/macrophages are thought to be recruited to the renal interstitium during calcium oxalate (CaOx) kidney stone disease for crystal clearance. Mitochondria play an important role in monocyte function during the immune response. We recently det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32272e9d2d73be509f34657272136c90
http://www.sciencedirect.com/science/article/pii/S2213231717307565

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N-acetylcysteine attenuates systemic platelet activation and cerebral vessel thrombosis in diabetes

Autor: Bin Wang, Karen Y. Stokes, Tak Yee Aw

Publikováno v: Redox Biology, Vol 14, Iss, Pp 218-228 (2018)
Redox Biology

Objective We previously demonstrated that diabetes exacerbates stroke-induced brain injury, and that this correlates with brain methylglyoxal (MG)-to-glutathione (GSH) status. Cerebral injury was reversed by N-acetylcysteine (NAC). Here we tested if

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e8a93cae5e654bcf0b785ddee72e49
https://doi.org/10.1016/j.redox.2017.09.005

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Time-dependent effect of rutin on skin fibroblasts membrane disruption following UV radiation

Autor: Agnieszka Gęgotek, Katarzyna Bielawska, Izabela Dobrzyńska, Michał Biernacki, Elżbieta Skrzydlewska

Publikováno v: Redox Biology
Redox Biology, Vol 12, Iss, Pp 733-744 (2017)

Chronic exposure of the skin to solar UV radiation induces a number of biological alterations, including a redox imbalance; therefore, there is an urgent need for skin cells protective compounds. The aim of this study was to determine the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e30b5ce712493c7352de7a0e4d05089
https://doi.org/10.1016/j.redox.2017.04.014

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Non-linear impact of glutathione depletion on C. elegans life span and stress resistance

Autor: Michael Ristow, Katrin Erler, Vanessa Stein, Dimitrios Tsitsipatis, Katrin Kreuzer, Nadine Urban, Lars-Oliver Klotz, Holger Steinbrenner, Franziska Hausig

Publikováno v: Redox Biology, Vol 11, Iss, Pp 502-515 (2017)
Redox Biology, 11
Redox Biology

The redox environment in cells and organisms is set by low-molecular mass and protein-bound thiols, with glutathione (GSH) representing a major intracellular redox buffer. Subtle thiol oxidation elicits signal transduction processes and adaptive resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3d0f5a81c28796cc1effeb8046a536
https://doi.org/10.1016/j.redox.2016.12.003

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Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

Autor: Antonio Cuadrado, Marta Pajares, Ana I. Rojo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Redox Biology, Vol 11, Iss, Pp 543-553 (2017)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology

Neurodegenerative diseases are linked to the accumulation of specific protein aggregates, suggesting an intimate connection between injured brain and loss of proteostasis. Proteostasis refers to all the processes by which cells control the abundance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f92176ef6df1b38f56b20a10b5b1ad8

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