The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

Autor: Maire Gavagan, Noel Jameson, Jesse G Zalatan

Publikováno v: eLife, Vol 12 (2023)

Multiple signaling pathways regulate the kinase GSK3β by inhibitory phosphorylation at Ser9, which then occupies the GSK3β priming pocket and blocks substrate binding. Since this mechanism should affect GSK3β activity toward all primed substrates,

Externí odkaz: https://doaj.org/article/f077bb6a96474732a8221b3da9b2deaa

Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β-catenin signaling pathway

Autor: Yang Qingli, X. L. Ma, Shi Jie, Zhang Zhenghai, Ji Yanru, Wei Lianhui, Dong Yan, Hu‐Nan Sun, Sun Yufeng, Song Shumin, Mei Xuesong, Xing‐Rong Sun

Publikováno v: Food Science & Nutrition
Food Science & Nutrition, Vol 9, Iss 4, Pp 1833-1841 (2021)

Foodborne protein hydrolysates exhibit biological activity that may be therapeutic in a number of human disease settings. Hemp peptides (HP) generated by controlled hydrolysis of hemp proteins have a number of health benefits and are of pharmaceutica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbb0033970f36720e430aba50ae1231
https://pubmed.ncbi.nlm.nih.gov/33841802

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Correction of RNA-Binding Protein CUGBP1 and GSK3β Signaling as Therapeutic Approach for Congenital and Adult Myotonic Dystrophy Type 1.

Autor: Timchenko L; Departments of Neurology and Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, OH 45229, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2019 Dec 21; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 21.