Zobrazeno 1 - 10
of 2 747
pro vyhledávání: '"GSK3β"'
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background The histone-lysine N-methyltransferase SMYD1, which is specific to striated muscle, plays a crucial role in regulating early heart development. Its deficiency has been linked to the occurrence of congenital heart disease. Neverthe
Externí odkaz:
https://doaj.org/article/900b3d2aba744013ae638df866c7e395
Autor:
Zuxi Feng, Yanghuan Ou, Xueqiang Deng, Minghao Deng, Xiaohua Yan, Leifeng Chen, Fan Zhou, Liang Hao
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Background Deubiquitinating enzymes (DUBs) are pivotal in maintaining cell homeostasis by regulating substrate protein ubiquitination in both healthy and cancer cells. Ubiquitin-specific protease 10 (USP10) belongs to the DUB family. In this
Externí odkaz:
https://doaj.org/article/a271d14a4a3747e086100fa1ec8bb918
Autor:
Yanlian Xiong, Yaru Si, Rengui Quan, Xingyu Huo, Juntong Chen, Jinyu Xu, Zhonglin Jiang, Feibo Xu, Ranran Liu, Qiang Fu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Premature ovarian insufficiency (POI), a major cause of female infertility, is defined as follicular atresia and a rapid loss of germ cells in women of reproductive age due to ovarian failure. Recently, findings from several studies have ind
Externí odkaz:
https://doaj.org/article/c9dce9e1b40f4f8b806a28f5c48cf6e5
Autor:
Shujun Yang, Liying Pei, Zijie Huang, Yinsheng Zhong, Jun Li, Yinghui Hong, Huibao Long, Xuxiang Chen, Changqing Zhou, Guanghui Zheng, Chaotao Zeng, Haidong Wu, Tong Wang
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-15 (2024)
Abstract Background Myocardial infarction (MI) leads to enhanced activity of cardiac fibroblasts (CFs) and abnormal deposition of extracellular matrix proteins, resulting in cardiac fibrosis. Tartrate-resistant acid phosphatase 5 (ACP5) has been show
Externí odkaz:
https://doaj.org/article/242d850a424a4905b2a9e4ba2957e691
Publikováno v:
Brain and Behavior, Vol 14, Iss 10, Pp n/a-n/a (2024)
ABSTRACT Introduction Alzheimer's disease (AD) is a neurodegenerative disease characterized by Amyloid plaques and neurofibrillary tangles. We explored the potential mechanism by which Danggui Shaoyao San (DSS) modulates central glucose metabolism vi
Externí odkaz:
https://doaj.org/article/64b86846abcc41839e7d2594ed8752ca
Autor:
Lin Liang, Chunxue Yue, Wentao Li, Jingqiong Tang, Qian He, Feng Zeng, Jiaying Cao, Siyi Liu, Yan Chen, Xin Li, Yanhong Zhou
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e37958- (2024)
In recent years, immunotherapy has emerged as an effective approach for treating tumors, with programmed cell death ligand 1 (PD-L1)/programmed cell death protein-1 (PD-1) immune checkpoint blockade (ICB) being a promising strategy. However, suboptim
Externí odkaz:
https://doaj.org/article/d77c4752af6b4eeb9365452fa1ab525c
Publikováno v:
Brain Research Bulletin, Vol 217, Iss , Pp 111071- (2024)
Purpose: Cerebral ischemia-reperfusion (CIR) injury is a devastating consequence of stroke characterized by oxidative stress-induced neuronal damage. Electroacupuncture (EA) has emerged as a potential therapeutic intervention for ischemic stroke, but
Externí odkaz:
https://doaj.org/article/c8e240d5a3304c76bef0ff47451b7656
Autor:
Jin-Meng Lv, Yi-Long Gao, Lu-Ying Wang, Bao-Dong Li, Yong-Lin Shan, Zi-Qiang Wu, Qing-Meng Lu, Heng-Yue Peng, Ting-Ting Zhou, Xiao-Ming Li, Li-Min Zhang
Publikováno v:
Brain Research Bulletin, Vol 217, Iss , Pp 111059- (2024)
Background: Cognitive dysfunction, encompassing perioperative psychological distress and cognitive impairment, is a prevalent postoperative complication within the elderly population, and in severe cases, it may lead to dementia. Building upon our pr
Externí odkaz:
https://doaj.org/article/ea9f8288c3764e6484b10e86d88ce770
Autor:
Mizuki Hino, Yasuto Kunii, Risa Shishido, Atsuko Nagaoka, Junya Matsumoto, Hiroyasu Akatsu, Yoshio Hashizume, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 1, Pp 121-128 (2024)
Abstract Aim The etiology of bipolar disorder (BD) remains unknown; however, lipid abnormalities in BD have received increasing attention in recent years. In this study, we examined the expression levels of enzyme proteins associated with the metabol
Externí odkaz:
https://doaj.org/article/6e606ffe19e94b8daa0f3078d123b804
Autor:
Chiara Lanzillotta, Antonella Tramutola, Simona Lanzillotta, Viviana Greco, Sara Pagnotta, Caterina Sanchini, Silvia Di Angelantonio, Elena Forte, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Flavia Agata Cimini, Ilaria Barchetta, Maria Gisella Cavallo, Andrea Urbani, D. Allan Butterfield, Fabio Di Domenico, Bindu D. Paul, Marzia Perluigi, Joao M.N. Duarte, Eugenio Barone
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103221- (2024)
Brain insulin resistance links the failure of energy metabolism with cognitive decline in both type 2 Diabetes Mellitus (T2D) and Alzheimer's disease (AD), although the molecular changes preceding overt brain insulin resistance remain unexplored. Abn
Externí odkaz:
https://doaj.org/article/981f6d63b120410193df144c24aca2cc